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AKT

Hypertrophic Cardiomyopathy β-Cardiac Myosin Mutation (P710R) Leads to Hypercontractility by Disrupting Super Relaxed State

[Proceedings of the National Academy of Sciences of the United States of America] The authors focused on the P710R mutation that dramatically decreased in vitro motility velocity and actin-activated ATPase, in contrast to other β-cardiac myosin mutations. Human induced pluripotent stem cell–cardiomyocytes with the P710R mutation produced significantly increased force compared with isogenic control cells.

CircC16orf62 Promotes Hepatocellular Carcinoma Progression through the miR-138-5p/PTK2/AKT Axis

[Cell Death & Disease] Gain or loss-of-function studies indicated that the reduction of CircC16orf62 expression promoted the proliferation, invasion, and glycolysis of hepatocellular carcinoma in vitro and in vivo.

Signaling Pathways in Cancer-Associated Fibroblasts and Targeted Therapy for Cancer

[Signal Transduction and Targeted Therapy] Scientists summarize the enormous amounts of findings on the signals mediating crosstalk of cancer-associated fibroblasts with cancer cells and its related targets or trials.

LncRNA Bmp1 Promotes the Healing of Intestinal Mucosal Lesions via the miR-128-3p/PHF6/PI3K/AKT Pathway

[Cell Death & Disease] The authors investigated the mechanisms of action of long non-coding RNA Bmp1 on damaged intestinal mucosa. They found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury.

Combined Inhibition of DDR1 and CDK4/6 Induces Synergistic Effects in ER-Positive, HER2-Negative Breast Cancer with PIK3CA/AKT1 Mutations

[Oncogene] DDR1 knockdown and DDR1 pharmacological inhibitor decreased cell growth and inhibited cell cycle progression in breast cancer cell lines, while enhanced the sensitivity of PIK3CA/AKT1 mutant cells to palbociclib.

D-Dopachrome Tautomerase Contributes to Lung Epithelial Repair via Atypical Chemokine Receptor 3-Dependent Akt Signaling

[Ebiomedicine] Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.

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