AKT

[Journal of Natural Products] An in-house library of 2576 plant extracts was screened on two melanoma cell lines with different oncogenic mutations leading to pathological ERK/AKT activity.

[Scientific Reports] The authors irradiated prostate cancer cells either with a single dose of 10 Gy x-ray or a multifractionated regimen with 10 fractions of 1 Gy.

[Liver International] 3-Mercaptopyruvate sulfurtransferase (MPST) protein expression was analyzed in HCC tumor tissues and matched adjacent tissues. The effect of MPST on HCC progression was studied in vitro and in vivo.

[Hepatology Communications] The authors established two lenvatinib-resistant HCC cell lines and identified integrin subunit beta 8 as a critical contributor to lenvatinib resistance in HCC.

[Molecular Cancer Research] Pharmacologic inhibition of mTOR kinase by Torin2 significantly sensitized lung squamous cell carcinoma cell lines to ionizing radiation.

[Cell Death Discovery] Researchers demonstrated that circular RNA PRKCI (circPRKCI), derived from the PRKCI gene, was elevated in breast cancer tissues and cell lines, especially in TNBC.