Tag results:

AMPK

Synthetic Adiponectin-Receptor Agonist, AdipoRon, Induces Glycolytic Dependence in Pancreatic Cancer Cells

[Cell Death & Disease] Treatment of PDAC cells with AdipoRon led to mitochondrial uncoupling and loss of ATP production. Concomitantly, AdipoRon-treated cells increased glucose uptake and utilization.

Itraconazole-Induced the Activation of Adenosine 5′-Monophosphate (AMP)-Activated Protein Kinase Inhibits Tumor Growth of Melanoma via Inhibiting ERK Signaling

[Cell Biochemistry and Biophysics] Scientists investigated the function of itraconazole-induced AMP-activated protein kinase alpha (AMPKα) in melanoma progression through ERK signaling.

Enrichment of the Exocytosis Protein STX4 in Skeletal Muscle Remediates Peripheral Insulin Resistance and Alters Mitochondrial Dynamics via Drp1

[Nature Communications] Researchers showed that transgenic skeletal muscle-specific STX4 enrichment in mice reverses established insulin resistance and improves mitochondrial function in the context of diabetogenic stress.

Phosphodiesterase 4D Promotes Angiotensin II-Induced Hypertension in Mice via Smooth Muscle Cell Contraction

[Communications Biology] Researchers revealed that phosphodiesterase (PDE) 4D expression was upregulated in the aortas of experimental hypertension induced by angiotensin II.

AMPK-PERK Axis Represses Oxidative Metabolism and Enhances Apoptotic Priming of Mitochondria in Acute Myeloid Leukemia

[Cell Reports] Scientists found that selective AMP-activated protein kinase (AMPK)-activating compounds killed acute myeloid leukemia (AML) cells by rewiring mitochondrial metabolism that primed mitochondria to apoptosis by BH3 mimetics, holding therapeutic promise in AML.

Copper Depletion Modulates Mitochondrial Oxidative Phosphorylation to Impair Triple Negative Breast Cancer Metastasis

[Nature Communications] Using two independent TNBC models, the authors reported a discrete subpopulation of highly metastatic SOX2/OCT4+ cells within primary tumors that exhibitrf elevated intracellular copper levels and a marked sensitivity to tetrathiomolybdate.

Popular