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AMPK

PPARβ/δ Accelerates Bone Regeneration in Diabetic Mellitus by Enhancing AMPK/mTOR Pathway-Mediated Autophagy

[Stem Cell Research & Therapy] Investigators explored the effects of PPARβ/δ agonist on the regeneration of diabetic bone defects and the osteogenic differentiation of rat bone marrow MSCs under a pathological high-glucose condition.

Metabolic Profiling of Attached and Detached Metformin and 2-Deoxy-D-Glucose Treated Breast Cancer Cells Reveals Adaptive Changes in Metabolome of Detached Cells

[Scientific Reports] Scientists performed LC/MS metabolic profiling on separated attached and detached MDA-MB-231 cells treated with metformin and/or 2-deoxy-D-glucose and found that the metabolic profile of detached cells was closer to untreated control cells, suggesting detachment might help cells adapt to energy stress.

Activation of AMPKα1 Is Essential for Regulatory T Cell Function and Autoimmune Liver Disease Prevention

[Cellular & Molecular Immunology] Both transplantation of wild-type bone marrow and adoptive transfer of wild-type Treg cells could prevent liver injury in AMPKα1-KO mice.

Aronia melanocarpa Polysaccharide Ameliorates Inflammation and Aging in Mice by Modulating the AMPK/SIRT1/NF-κB Signaling Pathway and Gut Microbiota

[Scientific Reports] Scientists evaluated the delay and protection of Aronia melanocarpa polysaccharide (AMP) obtained from Aronia melanocarpa fruit on aging mice by D-Galactose induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.

A Novel and Highly Effective Mitochondrial Uncoupling Drug in T Cell Leukemia

[Blood] MB1-47 treatment in T cell acute lymphoblastic leukemia cells robustly inhibited cell proliferation via both cytostatic and cytotoxic effects as a result of compromised mitochondrial energy and metabolite depletion, which severely impaired nucleotide biosynthesis.

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