To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.
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Scientists discuss the unique physiology of antibody-secreting cells and how naive B cells undergo epigenetic and genome architectural reorganization to acquire the necessary functions to support antibody production.
Scientists summarize recent advances in the understanding of the mechanisms of activation of the NLRP6 inflammasome and discuss its relevance to human disease.
To isolate adipose-derived human microvascular endothelial cells, scientists analyzed the supernatant discarded when adipose stem cells is isolated from the adipose-derived stromal vascular fraction.
[Tissue Engineering and Regenerative Medicine]
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Ryu, Y. H., Moon, S.-H., Kim, K. J., Jun, Y. J., Oh, D. Y., Kim, S., & Rhie, J.-W. (2021). A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-021-00332-5 Cite
24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
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Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
Scientists investigated the effect of 5, 10, or 20% pHPL in culture media on adipose-derived stromal/stem cell proliferation and phenotypic marker expression.
[Cells Tissues Organs]
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Researchers demonstrated that epithelial–mesenchymal transition in prostate tumors was promoted by obesity and suppressed upon pharmacological adipose stromal cells depletion in HiMyc mice, a spontaneous genetic model of prostate cancer.
[npj Precision Oncology]
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Su, F., Daquinag, A. C., Ahn, S., Saha, A., Dai, Y., Zhao, Z., DiGiovanni, J., & Kolonin, M. G. (2021). Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium. Npj Precision Oncology, 5(1), 1–10. https://doi.org/10.1038/s41698-021-00160-9 Cite
Researchers showed that 1,2,4-TTB (1 mM) markedly suppressed nigericin- or ATP-induced NLRP3 inflammasome activation, thus decreased caspase-1 activation and IL-1β secretion in immortalized murine bone marrow-derived macrophages (iBMDMs) and in primary mouse microglia.
[Acta Pharmacologica Sinica]
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1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis | Acta Pharmacologica Sinica. (n.d.). Retrieved March 1, 2021, from https://www.nature.com/articles/s41401-021-00613-8 Cite
Researchers examined the anti-oxidative potential of human amniotic membrane-derived MSC-conditioned medium treatment during in vitro culture on mouse preimplantation embryo development and antioxidant gene expression in the forkhead box O pathway.
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Ra, K., Oh, H. J., Kim, E. Y., Kang, S. K., Ra, J. C., Kim, E. H., Park, S. C., & Lee, B. C. (2021). Comparison of Anti-Oxidative Effect of Human Adipose- and Amniotic Membrane-Derived Mesenchymal Stem Cell Conditioned Medium on Mouse Preimplantation Embryo Development. Antioxidants, 10(2), 268. https://doi.org/10.3390/antiox10020268 Cite
Scientists showed that the DNA-binding inflammasome receptor AIM2 had a T cell-intrinsic and inflammasome-independent role in the function of T regulatory cells.
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Chou, W.-C., Guo, Z., Guo, H., Chen, L., Zhang, G., Liang, K., Xie, L., Tan, X., Gibson, S. A., Rampanelli, E., Wang, Y., Montgomery, S. A., Brickey, W. J., Deng, M., Freeman, L., Zhang, S., Su, M. A., Chen, X., Wan, Y. Y., & Ting, J. P.-Y. (2021). AIM2 in regulatory T cells restrains autoimmune diseases. Nature, 1–6. https://doi.org/10.1038/s41586-021-03231-w Cite
Scientists investigate the trends in injectable scaffolds for adipose-derived stromal cell (ASC) delivery in the dermis, and injectable or implantable scaffolds for ASC delivery in the subcutis.
[Stem Cell Research & Therapy]
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Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved January 23, 2021, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02132-5 Cite