Defining HPV-Specific B Cell Responses in Patients with Head and Neck Cancer

Researchers showed that human papillomavirus (HPV)-specific B cell responses were detectable in samples from patients with HPV-positive head and neck cancers, with active production of HPV-specific IgG antibodies in situ.
[Nature]
Defining HPV-specific B cell responses in patients with head and neck cancer | Nature. (n.d.). Retrieved November 24, 2020, from https://www.nature.com/articles/s41586-020-2931-3 Cite
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Scutellarin Ameliorates Pulmonary Fibrosis through Inhibiting NF-κB/NLRP3-Mediated Epithelial–Mesenchymal Transition and Inflammation

Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation | Cell Death & Disease. (n.d.). Retrieved November 19, 2020, from https://www.nature.com/articles/s41419-020-03178-2 Cite
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PCSK9 Regulates Pyroptosis via mtDNA Damage in Chronic Myocardial Ischemia

This study was designed to test the hypothesis that proprotein convertase subtilisin/Kexin type 9 (PCSK9) regulates pyroptosis in cardiomyocytes during chronic myocardial ischemia. Primary cardiomyocytes were isolated from WT and PCSK9−/− mice.
[Basic Research in Cardiology]
Wang, X., Li, X., Liu, S., Brickell, A. N., Zhang, J., Wu, Z., Zhou, S., & Ding, Z. (2020). PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia. Basic Research in Cardiology, 115(6), 66. https://doi.org/10.1007/s00395-020-00832-w Cite
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Adipose Stem Cells and PRP Induce Vascular-Like Structures in a Dermal Regeneration Template

Integra® Dermal Regeneration Template was sprinkled with adipose-derived stem cells in complete medium supplemented with 10% Fetal Bovine Serum, or stromal vascular fraction, obtained from emulsified or non-emulsified fat, in medium supplemented with 2% platelet-rich plasma.
[Tissue Engineering]
Beccia, E., Carbone, A., Cecchino, L. R., Pedicillo, M. C., Annacontini, L., Lembo, F., Di Gioia, S., Parisi, D., Angiolillo, A., Pannone, G., Portincasa, A., & Conese, M. (2020). Adipose stem cells and PRP induce vascular-like structures in a Dermal Regeneration Template. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0175 Cite
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The Inhibitor Effect of RKIP on Inflammasome Activation and Inflammasome-Dependent Diseases

The authors showed that Raf kinase inhibitor protein negatively regulated the activation of the NLRP1, NLRP3, and NLRC4 inflammasomes.
[Cellular & Molecular Immunology]
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hADSCs Derived Extracellular Vesicles Inhibit NLRP3inflammasome Activation and Dry Eye

Investigators addressed the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles in a mouse model of dry eye disease and to investigate the underlying mechanisms involved.
[Scientific Reports]
Yu, C., Chen, P., Xu, J., Liu, Y., Li, H., Wang, L., & Di, G. (2020). hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye. Scientific Reports, 10(1), 14521. https://doi.org/10.1038/s41598-020-71337-8 Cite
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Characterization of Adipose-Derived Stromal/Stem Cell Spheroids versus Single-Cell Suspension in Cell Survival and Arrest of Osteoarthritis Progression

When adipose-derived stromal/stem cells (ASC) spheroid cultured in 3D were compared with ASCs cultured in 2D monolayer, the cell survival and chondrogenic potential were enhanced while the apoptosis was reduced in ASC spheroids.
[Journal of Biomedical Materials Research Part A]
Ko, J.-Y., Park, J., Kim, J., & Im, G.-I. (n.d.). Characterization of adipose-derived stromal/stem cell spheroids versus single-cell suspension in cell survival and arrest of osteoarthritis progression. Journal of Biomedical Materials Research Part A, n/a(n/a). https://doi.org/10.1002/jbm.a.37078 Cite
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Antibody-Secreting Cell Destiny Emerges during the Initial Stages of B-Cell Activation

Scientists investigated B cell fate programming and heterogeneity during anti-body secreting cells (ASCs) differentiation using T cell-independent models. They found that maximal ASC induction required at least eight cell divisions in vivo, with BLIMP-1 being required for differentiation at division eight.
[Nature Communications]
Scharer, C. D., Patterson, D. G., Mi, T., Price, M. J., Hicks, S. L., & Boss, J. M. (2020). Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nature Communications, 11(1), 3989. https://doi.org/10.1038/s41467-020-17798-x Cite
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