Tag Archives: ASC

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ASCs and Their Role in Obesity and Metabolic Diseases

The authors discuss adiposopathy with a focus on adiponiche dysfunction, and underline the mechanisms that control adipose tissue expansion and energy balance.

[Trends in Endocrinology and Metabolism]

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Intravenous Injection of Mesenchymal Stem Cell Spheroids Improves the Pulmonary Delivery and Prolongs In Vivo Survival

Murine adipose-derived MSC line m17.ASC was cultured in agarose-based microwell plates to obtain size-controlled m17.ASC spheroids of an average diameter and cell number of approximately 170 μm and 1100 cells/spheroid, respectively.

[Biotechnology Journal]

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BTK Operates a Phospho-Tyrosine Switch to Regulate NLRP3 Inflammasome Activity

Scientists showed that a well-established drug target, Bruton’s tyrosine kinase, affected several levels of NLRP3 regulation. BTK directly interacted with NLRP3 in immune cells and phosphorylates four conserved tyrosine residues upon inflammasome activation, in vitro and in vivo.

[Journal of Experimental Medicine]

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Adipose-Derived Stem/Stromal Cell Secretome Modulates Breast Cancer Cell Proliferation and Differentiation State towards Aggressiveness

To understand the role of the adipose-derived stem cell secretome in breast cancer cell proliferation, death, and phenotype alteration, adipose-derived stem cell-conditioned medium was used to cultivate MCF-7 and MDA-MB-231 cells.

[Biochimie]

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Antibody Secreting Cells Are Critically Dependent on Integrin α4β7/MAdCAM-1 for Intestinal Recruitment and Control of the Microbiota during Chronic Colitis

β7 deficiency and MAdCAM-1 blockade specifically depleted antibody secreting cells from the colonic LP, leading to a fecal pan-immunoglobulin deficit, severe colitis, and alterations of microbiota composition.

[Mucosal Immunology]

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Assessing Donor-to-Donor Variability in Human Intestinal Organoid Cultures

Scientists investigated donor-to-donor variability in human gut adult stem cell organoids. They examined intestinal developmental pathways during culture differentiation in ileum- and colon-derived cultures established from multiple donors, showing that differentiation patterns were consistent among cultures.

[Stem Cell Reports]

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An Integrin αEβ7-Dependent Mechanism of IgA Transcytosis Requires Direct Plasma Cell Contact with Intestinal Epithelium

Flow cytometric, ultrastructural and transcriptional profiling showed that αEβ7-expressing antibody-secreting cells represented an undescribed subset of terminally-differentiated intestinal plasma cells that established direct cell to cell contact with intestinal epithelium.

[Mucosal Immunology]

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Understanding the “SMART” Features of Hematopoietic Stem Cells and Beyond

The authors describe the “self-renewal, multi-lineage differentiation, apoptosis, rest, and trafficking” or “SMART” model, which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell type.

[Science China-Life Sciences]

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