Researchers examined the anti-oxidative potential of human amniotic membrane-derived MSC-conditioned medium treatment during in vitro culture on mouse preimplantation embryo development and antioxidant gene expression in the forkhead box O pathway.
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Ra, K., Oh, H. J., Kim, E. Y., Kang, S. K., Ra, J. C., Kim, E. H., Park, S. C., & Lee, B. C. (2021). Comparison of Anti-Oxidative Effect of Human Adipose- and Amniotic Membrane-Derived Mesenchymal Stem Cell Conditioned Medium on Mouse Preimplantation Embryo Development. Antioxidants, 10(2), 268. https://doi.org/10.3390/antiox10020268 Cite
Scientists showed that the DNA-binding inflammasome receptor AIM2 had a T cell-intrinsic and inflammasome-independent role in the function of T regulatory cells.
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Chou, W.-C., Guo, Z., Guo, H., Chen, L., Zhang, G., Liang, K., Xie, L., Tan, X., Gibson, S. A., Rampanelli, E., Wang, Y., Montgomery, S. A., Brickey, W. J., Deng, M., Freeman, L., Zhang, S., Su, M. A., Chen, X., Wan, Y. Y., & Ting, J. P.-Y. (2021). AIM2 in regulatory T cells restrains autoimmune diseases. Nature, 1–6. https://doi.org/10.1038/s41586-021-03231-w Cite
Scientists investigate the trends in injectable scaffolds for adipose-derived stromal cell (ASC) delivery in the dermis, and injectable or implantable scaffolds for ASC delivery in the subcutis.
[Stem Cell Research & Therapy]
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Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved January 23, 2021, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02132-5 Cite
Researchers showed that human papillomavirus (HPV)-specific B cell responses were detectable in samples from patients with HPV-positive head and neck cancers, with active production of HPV-specific IgG antibodies in situ.
Investigators discovered that scutellarin suppressed inflammation and epithelial–mesenchymal transition in BLM-induced pulmonary fibrosis through NF-κB/NLRP3 signaling.
[Cell Death & Disease]
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This study was designed to test the hypothesis that proprotein convertase subtilisin/Kexin type 9 (PCSK9) regulates pyroptosis in cardiomyocytes during chronic myocardial ischemia. Primary cardiomyocytes were isolated from WT and PCSK9−/− mice.
[Basic Research in Cardiology]
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Integra® Dermal Regeneration Template was sprinkled with adipose-derived stem cells in complete medium supplemented with 10% Fetal Bovine Serum, or stromal vascular fraction, obtained from emulsified or non-emulsified fat, in medium supplemented with 2% platelet-rich plasma.
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Beccia, E., Carbone, A., Cecchino, L. R., Pedicillo, M. C., Annacontini, L., Lembo, F., Di Gioia, S., Parisi, D., Angiolillo, A., Pannone, G., Portincasa, A., & Conese, M. (2020). Adipose stem cells and PRP induce vascular-like structures in a Dermal Regeneration Template. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0175 Cite
The authors showed that Raf kinase inhibitor protein negatively regulated the activation of the NLRP1, NLRP3, and NLRC4 inflammasomes.
[Cellular & Molecular Immunology]
Investigators addressed the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles in a mouse model of dry eye disease and to investigate the underlying mechanisms involved.
When adipose-derived stromal/stem cells (ASC) spheroid cultured in 3D were compared with ASCs cultured in 2D monolayer, the cell survival and chondrogenic potential were enhanced while the apoptosis was reduced in ASC spheroids.
[Journal of Biomedical Materials Research Part A]
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Ko, J.-Y., Park, J., Kim, J., & Im, G.-I. (n.d.). Characterization of adipose-derived stromal/stem cell spheroids versus single-cell suspension in cell survival and arrest of osteoarthritis progression. Journal of Biomedical Materials Research Part A, n/a(n/a). https://doi.org/10.1002/jbm.a.37078 Cite
Scientists investigated B cell fate programming and heterogeneity during anti-body secreting cells (ASCs) differentiation using T cell-independent models. They found that maximal ASC induction required at least eight cell divisions in vivo, with BLIMP-1 being required for differentiation at division eight.
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