Osteogenic Differentiation of Human Mesenchymal Stromal Cells and Fibroblasts Differs Depending on Tissue Origin and Replicative Senescence

To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.
[Scientific Reports]
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Epigenetic Gene Regulation in Plasma Cells

Scientists discuss the unique physiology of antibody-secreting cells and how naive B cells undergo epigenetic and genome architectural reorganization to acquire the necessary functions to support antibody production.
[Immunological Reviews]
Patterson, D. G., Kania, A. K., Zuo, Z., Scharer, C. D., & Boss, J. M. (n.d.). Epigenetic gene regulation in plasma cells. Immunological Reviews, n/a(n/a). https://doi.org/https://doi.org/10.1111/imr.12975 Cite
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NLRP6 in Host Defense and Intestinal Inflammation

Scientists summarize recent advances in the understanding of the mechanisms of activation of the NLRP6 inflammasome and discuss its relevance to human disease.
[Cell Reports]
Venuprasad, K., & Theiss, A. L. (2021). NLRP6 in host defense and intestinal inflammation. Cell Reports, 35(4). https://doi.org/10.1016/j.celrep.2021.109043 Cite
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A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction

To isolate adipose-derived human microvascular endothelial cells, scientists analyzed the supernatant discarded when adipose stem cells is isolated from the adipose-derived stromal vascular fraction.
[Tissue Engineering and Regenerative Medicine]
Ryu, Y. H., Moon, S.-H., Kim, K. J., Jun, Y. J., Oh, D. Y., Kim, S., & Rhie, J.-W. (2021). A Novel Hypothesis and Characterization to Isolate Microvascular Endothelial Cells Simultaneously with Adipose-Derived Stem Cells from the Human Adipose-Derived Stromal Vascular Fraction. Tissue Engineering and Regenerative Medicine. https://doi.org/10.1007/s13770-021-00332-5 Cite
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The Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Hepatic Regeneration in Miniature Pigs after Liver Ischemia-Reperfusion Combined with Partial Resection

24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
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Adipose-Derived Stromal/Stem Cell Culture: Effects of Different Concentrations of Human Platelet Lysate in Media

Scientists investigated the effect of 5, 10, or 20% pHPL in culture media on adipose-derived stromal/stem cell proliferation and phenotypic marker expression.
[Cells Tissues Organs]
Ballesteros, O. R., Brooks, P. T., Haastrup, E. K., Fischer-Nielsen, A., Munthe-Fog, L., & Svalgaard, J. D. (2021). Adipose-Derived Stromal/Stem Cell Culture: Effects of Different Concentrations of Human Platelet Lysate in Media. Cells Tissues Organs, 1–9. https://doi.org/10.1159/000513604 Cite
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Progression of Prostate Carcinoma Is Promoted by Adipose Stromal Cell-Secreted CXCL12 Signaling in Prostate Epithelium

Researchers demonstrated that epithelial–mesenchymal transition in prostate tumors was promoted by obesity and suppressed upon pharmacological adipose stromal cells depletion in HiMyc mice, a spontaneous genetic model of prostate cancer.
[npj Precision Oncology]
Su, F., Daquinag, A. C., Ahn, S., Saha, A., Dai, Y., Zhao, Z., DiGiovanni, J., & Kolonin, M. G. (2021). Progression of prostate carcinoma is promoted by adipose stromal cell-secreted CXCL12 signaling in prostate epithelium. Npj Precision Oncology, 5(1), 1–10. https://doi.org/10.1038/s41698-021-00160-9 Cite
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1,2, 4-Trimethoxybenzene Selectively Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Autoimmune Encephalomyelitis

Researchers showed that 1,2,4-TTB (1 mM) markedly suppressed nigericin- or ATP-induced NLRP3 inflammasome activation, thus decreased caspase-1 activation and IL-1β secretion in immortalized murine bone marrow-derived macrophages (iBMDMs) and in primary mouse microglia.
[Acta Pharmacologica Sinica]
1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis | Acta Pharmacologica Sinica. (n.d.). Retrieved March 1, 2021, from https://www.nature.com/articles/s41401-021-00613-8 Cite
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Comparison of Anti-Oxidative Effect of Human Adipose- and Amniotic Membrane-Derived Mesenchymal Stem Cell Conditioned Medium on Mouse Preimplantation Embryo Development

Researchers examined the anti-oxidative potential of human amniotic membrane-derived MSC-conditioned medium treatment during in vitro culture on mouse preimplantation embryo development and antioxidant gene expression in the forkhead box O pathway.
[Antioxidants]
Ra, K., Oh, H. J., Kim, E. Y., Kang, S. K., Ra, J. C., Kim, E. H., Park, S. C., & Lee, B. C. (2021). Comparison of Anti-Oxidative Effect of Human Adipose- and Amniotic Membrane-Derived Mesenchymal Stem Cell Conditioned Medium on Mouse Preimplantation Embryo Development. Antioxidants, 10(2), 268. https://doi.org/10.3390/antiox10020268 Cite
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AIM2 in Regulatory T Cells Restrains Autoimmune Diseases

Scientists showed that the DNA-binding inflammasome receptor AIM2 had a T cell-intrinsic and inflammasome-independent role in the function of T regulatory cells.
[Nature]
Chou, W.-C., Guo, Z., Guo, H., Chen, L., Zhang, G., Liang, K., Xie, L., Tan, X., Gibson, S. A., Rampanelli, E., Wang, Y., Montgomery, S. A., Brickey, W. J., Deng, M., Freeman, L., Zhang, S., Su, M. A., Chen, X., Wan, Y. Y., & Ting, J. P.-Y. (2021). AIM2 in regulatory T cells restrains autoimmune diseases. Nature, 1–6. https://doi.org/10.1038/s41586-021-03231-w Cite
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Differences of Embedding Adipose-Derived Stromal Cells in Natural and Synthetic Scaffolds for Dermal and Subcutaneous Delivery

Scientists investigate the trends in injectable scaffolds for adipose-derived stromal cell (ASC) delivery in the dermis, and injectable or implantable scaffolds for ASC delivery in the subcutis.
[Stem Cell Research & Therapy]
Differences of embedding adipose-derived stromal cells in natural and synthetic scaffolds for dermal and subcutaneous delivery | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved January 23, 2021, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02132-5 Cite
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