ASC

[Proceedings of the National Academy of Sciences of the United States of America] Researchers reported that desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, played an essential role during atherogenesis, serving as a key molecule integrating cholesterol homeostasis and immune responses in macrophages.

[Scientific Reports] Scientists clarified the role and mechanisms of action of apoptosis-associated speck-like protein containing a caspase recruitment domain in pancreatic ductal adenocarcinoma using clinical evidence and in vitro data.

[Oxidative Medicine and Cellular Longevity] Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus.

[US Urology Partners, Inc.] US Urology Partners, Inc. has created a Robotic Surgery Institute at Central Ohio Urology Surgery Center to advance the use of robotics technology in the field of urology. The new Institute was recently the site of one of the first robotic prostatectomies in the nation to be performed at an ambulatory surgery center.

[Cell Death Discovery] Researchers evaluated the effects of Pgam5 on neurological deficits and neuroinflammation of controlled cortical impact-induced TBI mouse model in vivo and LPS+ ATP-induced microglia model in vitro.

[Trends in Endocrinology and Metabolism] The authors discuss adiposopathy with a focus on adiponiche dysfunction, and underline the mechanisms that control adipose tissue expansion and energy balance.