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Understanding the “SMART” Features of Hematopoietic Stem Cells and Beyond

[Science China-Life Sciences] The authors describe the “self-renewal, multi-lineage differentiation, apoptosis, rest, and trafficking” or “SMART” model, which has been developed based on data derived from studies of HSCs as the most well-characterized stem cell type.

SARS-CoV-2 N Protein Promotes NLRP3 Inflammasome Activation to Induce Hyperinflammation

[Nature Communications] Scientists showed a distinct mechanism by which SARS-CoV-2 N protein promoted NLRP3 inflammasome activation to induce hyperinflammation.

MicroRNA-26a Shuttled by Extracellular Vesicles Secreted from Adipose-Derived Mesenchymal Stem Cells Reduce Neuronal Damage through KLF9-Mediated Regulation of TRAF2/KLF2 Axis

[Adipocyte] Researchers investigated the role of miR-26a shuttled by extracellular vesicles derived from adipose-derived MSCs in neuronal damage.

Bio-Engineering a Prevascularized Human Tri-layered Skin Substitute Containing a Hypodermis

[Acta Biomaterialia] Severe injuries to skin including hypodermis require full-thickness skin replacement. Researchers bio-engineered a tri-layered human skin substitute containing the epidermis, dermis, and hypodermis.

Effect of Adipose Derived Mesenchymal Stem Cells on Multiple Organ Injuries in Diet-Induced Obese Mice

[Tissue Barriers] Scientists studied the effect of adipose-derived MSCs on obesity-induced multi-organ injuries in a diet-induced obese mouse model.

Enhanced Cellular Engraftment of Adipose-Derived Mesenchymal Stem Cell Spheroids by Using Nanosheets as Scaffolds

[Scientific Reports] Researchers showed an effective method for transplantation of adipose-derived MSCs spheroids onto skin wounds in order to efficiently cure refractory ulcers.

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