ATP-binding cassette

[Cell Death & Disease] Researchers found a potential association between deletion of smooth muscle 22α and deregulated nuclear receptors liver X receptors /retinoid X receptor signaling in mice.

[American Journal of Respiratory and Critical Care Medicine] Using human airway smooth muscle cells in culture as a model, the authors reported that activation of the cell surface β2-adrenoceptor, a Gs-coupled G protein-coupled receptor, evoked cAMP egress to the extracellular space.

[Cellular Oncology] Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.

[Environmental Science and Pollution Research] Researchers investigated the effects of polybrominated diphenyl ethers used as flame retardants on phenotypic features of melanoma cells that are important for cancer.

[Thoracic Cancer] Researchers identified the precise role of circular RNA circ_0058357 in the functional properties of DDP-resistant non-small cell lung cancer cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists presented cryogenic electron microscopy structures of human ABCB4 in three distinct functional conformations. They recapitulated the substrate specificity of ABCB4 in vitro and confirmed the role of the key tryptophan residue.