ATP-binding cassette

[Nature Communications] Investigators reported that the secretory extracellular matrix protein-1 isoform induced tumorigenesis through the GPR motif binding to integrin αXβ2 and the activation of AKT/FAK/Rho/cytoskeleton signaling.

[Scientific Reports] Expression levels of messenger RNAs and proteins were examined in the ipsilateral cortex, and mimics and inhibitors of selective miRNAs were transfected into Neuro-2a cells before oxygen–glucose deprivation.

[iScience] Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.

[Scientific Reports] Scientists explored the role of inhibition of MDR1 or ABCG2 in sensitizing liver cancer stem cells to doxorubicin, the most frequently used chemotherapeutic agent in treating liver cancer.

[Nature Communications] The authors investigated the energetic demands of ATP binding cassette (ABC) transporters in the context of the metabolic adaptations of chemoresistant cancer cells and developed methylation-controlled J protein mimetics that could attenuate mitochondrial respiration and safely overcome chemoresistance in vitro and in vivo.

[Nature Metabolism] Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.