ATR

[Nature Communications] Scientists generated conditional, inducible knock-out mice for Rpap3 to inactivate the HSP90 component of R2TP in the intestinal epithelium. Proliferative stem cells and progenitors deficient for Rpap3 failed to import RNA polymerase II into the nucleus and they induced p53, cell cycle arrest and apoptosis.

[Acta Pharmacologica Sinica] Researchers carried out research to discover a novel alternative drug targeting the oncogenic NFAT signaling pathway for Glioblastoma multiforme therapy.

[Breast Cancer Research] Researchers showed that sublethal doxorubicin treatment led to increased migration and invasion in otherwise non-invasive MCF7 breast cancer cells.

[Scientific Reports] Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.

[Nature Communications] Investigators showed a mechanism utilised by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK.

[Aging] The authors investigated the mechanism underlying the toxic effect of cobalt nanoparticles (CoNPs) on HSCs/hematopoietic progenitor cells and to determine the protective effect of selenomethionine against CoNPs in vitro and in vivo.