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AXIN1

SLC38A4 Functions as a Tumour Suppressor in Hepatocellular Carcinoma through Modulating Wnt/β-Catenin/MYC/HMGCS2 Axis

[British Journal of Cancer] Researchers identified a common molecular event which would provide a novel prognostic biomarker and therapeutic target for hepatocellular carcinoma.

RNA m6A Reader YTHDF2 Facilitates Lung Adenocarcinoma Cell Proliferation and Metastasis by Targeting the AXIN1/Wnt/β-Catenin Signaling

[Cell Death & Disease] we found that YTHDF2 was significantly upregulated in Lung adenocarcinoma (LUAD) compared with paracancerous normal tissues, and YTHDF2 knockdown drastically inhibited, while its overexpression promoted, cell growth, colony formation and migration of LUAD cells in vitro.

Genomic Landscape of Hepatocarcinogenesis

[Journal of Human Genetics] The recent genetic analysis uncovered a distinctive driver gene landscape in precancerous lesions, arguing a discontinuous process at early hepatocellular carcinoma development.

KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway

[Circulation Research] Researchers showed that KPT-330 prevented, attenuated and mitigated calcific nodule formation in heart valve interstitial cells in vitro, and prevented calcific aortic valve disease in Klotho-/- mice.

Nuclear Partitioning of Prohibitin 1 Inhibits Wnt/β-Catenin-Dependent Intestinal Tumorigenesis

[Oncogene] Using mice with inducible intestinal epithelial cell-specific deletion of Phb1 and mice with IEC-specific overexpression of Phb1, investigators demonstrated that IEC-specific PHB1 combats intestinal tumorigenesis in the ApcMin/+ mouse model by inhibiting Wnt/β-catenin signaling.

Inhibition of Axin1 in Osteoblast Precursor Cells Leads to Defects in Postnatal Bone Growth through Suppressing Osteoclast Formation

[Bone Research] Osteoclast formation in primary bone marrow derived microphage (BMM) cells was significantly decreased when BMM cells were cultured with conditioned media (CM) collected from osteoblasts derived from Axin1Osx mice compared with BMM cells cultured with CM derived from WT mice.

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