Silencing of Sphingosine kinase 1 Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes

Investigators demonstrated that the Sphingosine kinase-1 silencing in neonatal mouse cardiomyocytes facilitated their postnatal maturation in both physiological and stress conditions.
[International Journal of Molecular Sciences]
Jozefczuk, E., Szczepaniak, P., Guzik, T. J., & Siedlinski, M. (2021). Silencing of Sphingosine kinase 1 Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes. International Journal of Molecular Sciences, 22(7), 3616. https://doi.org/10.3390/ijms22073616 Cite
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GRK5 Is a Regulator of Fibroblast Activation and Cardiac Fibrosis

Researchers demonstrated using adult cardiac fibroblasts that genetic deletion of G protein-coupled receptor kinase 5 inhibits angiotensin II-mediated fibroblast activation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Angiotensin II-Induced Muscle Atrophy via PPARγ Suppression Is Mediated by miR-29b

Scientists identified peroxisome proliferator-activated receptor gamma (PPARγ) as a negative regulator of miR-29b, a microRNA that is able to promote multiple types of muscle atrophy. Suppression of miR-29b prevented AngII-induced muscle atrophy both in vitro and in vivo.
[Molecular Therapy-Nucleic Acids]
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Ontogeny of Arterial Macrophages Defines Their Functions in Homeostasis and Inflammation

Scientists combined macrophage fate-mapping analysis with single-cell RNA sequencing to establish their cellular identity during homeostasis, and in response to angiotensin-II (AngII)-induced arterial inflammation.
[Nature Communications]
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Dual Roles of Chromatin Remodeling Protein BRG1 in Angiotensin II-Induced Endothelial–Mesenchymal Transition

BRG1 knockdown or inhibition attenuated angiotensin II-induced endothelial–mesenchymal transition, as evidenced by down-regulation of CDH5, an endothelial marker, and up-regulation of COL1A2, a mesenchymal marker, in cultured vascular endothelial cells.
[Cell Death & Disease]
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