AngII

[Scientific Reports] Investigators investigated the role of lipid phosphate phosphatase 3 and lysophospholipid signaling in a well-defined model of pathologic aortic injury.

[Cell Death Discovery] Investigators established an in vitro model of alcoholic cardiomyopathy based on human induced pluripotent stem cell-derived cardiomyocytes.

[Circulation] Investigators utilized mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate C-C chemokine ligand 17.

[Molecular Medicine Reports] Chronic hypertension can lead to kidney damage, known as hypertensive nephropathy or hypertensive nephrosclerosis. The authors investigated the mechanisms by which endothelial progenitor cells repaired primary rat kidney cells.

[Pharmacological Research] The authors showed that the number of endothelial progenitor cells (EPCs) in hypertensive patients was significantly lower than that of normal population, and the cell function decreased with a higher proportion of EPCs at later stages.

[Science Translational Medicine] Researchers found that erythropoietin (EPO) promoted the formation of abdominal aortic aneurysm (AAA) in both Apoe−/− and wild type mice by enhancing angiogenesis, inflammation, collagen degradation, and apoptosis of smooth muscle cells and that EPO/EPO receptor signaling was essential for angiotensin II-induced AAA.