Jozefczuk, E., Szczepaniak, P., Guzik, T. J., & Siedlinski, M. (2021). Silencing of Sphingosine kinase 1 Affects Maturation Pathways in Mouse Neonatal Cardiomyocytes. International Journal of Molecular Sciences, 22(7), 3616. https://doi.org/10.3390/ijms22073616Cite
Scientists identified peroxisome proliferator-activated receptor gamma (PPARγ) as a negative regulator of miR-29b, a microRNA that is able to promote multiple types of muscle atrophy. Suppression of miR-29b prevented AngII-induced muscle atrophy both in vitro and in vivo.
Scientists combined macrophage fate-mapping analysis with single-cell RNA sequencing to establish their cellular identity during homeostasis, and in response to angiotensin-II (AngII)-induced arterial inflammation.
BRG1 knockdown or inhibition attenuated angiotensin II-induced endothelial–mesenchymal transition, as evidenced by down-regulation of CDH5, an endothelial marker, and up-regulation of COL1A2, a mesenchymal marker, in cultured vascular endothelial cells.