Lung-Resident Memory B Cells Established after Pulmonary Influenza Infection Display Distinct Transcriptional and Phenotypic Profiles

Scientists characterized tissue-resident memory B cells that are stably maintained in the lungs of mice after pulmonary influenza infection.
[Science Immunology]
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Integrative Bioinformatics and Experimental Analysis Revealed TEAD as Novel Prognostic Target for Hepatocellular Carcinoma and Its Roles in Ferroptosis Regulation

Investigators indicated that TEAD2/4 were significantly upregulated in HCC compared with normal tissues. Downregulation of TEAD2 promoted the death of HCC cells through inducing ferroptosis by iron accumulation and subsequent oxidative damage.
[Aging]
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Exploiting Natural Killer Cell Engagers to Control Pediatric B Cell Precursor Acute Lymphoblastic Leukemia

Investigators tested the in vitro effect of different NK cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and target either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.
[Cancer Immunology Research]
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Defective Humoral Immunity Disrupts Bile Acid Homeostasis Which Promotes Inflammatory Disease of the Small Bowel

Investigators used a CD19−/− mouse model of antibody-deficiency to demonstrate that a relationship exists between dysbiosis, defects in bile acid homeostasis, and gluten-sensitive enteropathy of the small intestine.
[Nature Communications]
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Cartesian Therapeutics Doses Patient with First Allogeneic RNA Cell Therapy for Multiple Myeloma

Cartesian Therapeutics announced that it has dosed the first patient in a Phase I/IIa multicenter clinical study evaluating Descartes-25, engineered to deliver a combination of synergistically active anti-myeloma therapies directly to tumor microenvironment, in patients with multiple myeloma.
[Cartesian Therapeutics]
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Gut Microbiota–Derived Metabolite 3-Idoleacetic Acid Together with LPS Induces IL-35+ B Cell Generation

Scientists investigated the regulatory effects of the gut microbiota on IL-35+ cells by using genetically modified mouse models of obesity.
[Microbiome]
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B Cell Depletion and SARS-CoV-2 Vaccine Responses in Neuroimmunologic Patients

Scientists investigated prospectively humoral and cellular responses to SARS-CoV-2 mRNA vaccination in 82 patients with neuroimmunologic disorders on anti-CD20 therapy and 82 age- and sex-matched healthy controls.
[Annals of Neurology]
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SARS-CoV-2 Vaccination Induces Immunological T Cell Memory Able to Cross-Recognize Variants from Alpha to Omicron

In subjects ∼6 months post-vaccination, 90% and 87% of memory T cell responses were preserved against variants on average by AIM assay, and 84% and 85% preserved against Omicron.
[Cell]
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Adenosine Receptor 2a Agonists Target Mouse CD11c+T-Bet+ B Cells in Infection and Autoimmunity

Researchers showed that administration of the A2A receptor agonist CGS-21680 depleted established CD11c+T-bet+ B cells in ehrlichial-infected mice, in a B cell-intrinsic manner.
[Nature Communications]
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Single-Cell Multi-Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19

Investigators used multi-omics single-cell analysis to probe the dynamic immune responses in hospitalized patients with stable or progressive course of COVID-19, explore V(D)J repertoires, and assess the cellular effects of tocilizumab.
[Nature Communications]
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Disrupting N-Glycan Expression on Tumor Cells Boosts Chimeric Antigen Receptor T Cell Efficacy against Solid Malignancies

The authors showed that multiple carcinomas expressed extracellular N-glycans, whose abundance negatively correlated with CAR T cell killing.
[Science Translational Medicine]
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