The single deletion of tumor necrosis factor receptor (TNFR) 1 induced subclinical colonic epithelial dysfunction and mucosal immune abnormalities, including accumulation of neutrophils and depletion of B cells.
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Liu, C. Y., Tam, S. S., Huang, Y., Dubé, P. E., Alhosh, R., Girish, N., Punit, S., Nataneli, S., Li, F., Bender, J. M., Washington, M. K., & Polk, D. B. (2020). TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108275 Cite
Scientists demonstrated that apoptosis induced by JQ1 was solely attributed to the pro-apoptotic protein Bim. Conversely, cell-cycle regulation by JQ1 was associated with multiple Myc-associated gene targets.
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Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation: Cell Reports. (n.d.). Retrieved October 23, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31279-1 Cite
Scientists characterized the immunopeptidomes of the two HLA-DR15 allomorphs DR2a and DR2b of human primary B cells and monocytes, thymus, and multiple sclerosis brain tissue.
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Wang, J., Jelcic, I., Mühlenbruch, L., Haunerdinger, V., Toussaint, N. C., Zhao, Y., Cruciani, C., Faigle, W., Naghavian, R., Foege, M., Binder, T. M. C., Eiermann, T., Opitz, L., Fuentes-Font, L., Reynolds, R., Kwok, W. W., Nguyen, J. T., Lee, J.-H., Lutterotti, A., … Martin, R. (2020). HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.09.054 Cite
By analyzing more than 500 monoclonal antibodies (mAbs) derived from B cells induced by numerous influenza virus vaccines and infections, we found mAbs targeting conserved neutralizing influenza virus hemagglutinin epitopes were polyreactive.
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Guthmiller, J. J., Lan, L. Y.-L., Fernández-Quintero, M. L., Han, J., Utset, H. A., Bitar, D. J., Hamel, N. J., Stovicek, O., Li, L., Tepora, M., Henry, C., Neu, K. E., Dugan, H. L., Borowska, M. T., Chen, Y.-Q., Liu, S. T. H., Stamper, C. T., Zheng, N.-Y., Huang, M., … Wilson, P. C. (2020). Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.005 Cite
The mechanisms by which regulatory T (Treg) cells differentially control allergic and autoimmune responses remain unclear. Researchers showed that Treg cells in food allergy had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4- and signal transducer and activator of transciription-6-dependent inhibition of Tgfb1 transcription.
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Turner, J. A., Stephen-Victor, E., Wang, S., Rivas, M. N., Abdel-Gadir, A., Harb, H., Cui, Y., Fanny, M., Charbonnier, L.-M., Fong, J. J. H., Benamar, M., Wang, L., Burton, O. T., Bansal, K., Bry, L., Zhu, C., Li, Q.-Z., Clement, R. L., Oettgen, H. C., … Chatila, T. A. (2020). Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.002 Cite
In vitro and in vivo experiments confirmed BCL11B as a tumor suppressor in hepatocellular carcinoma with inhibitory effects on proliferation, cell cycle progression, apoptosis, and mobility.
[Cell Death & Disease]
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Yang, W.-J., Sun, Y.-F., Jin, A.-L., Lv, L.-H., Zhu, J., Wang, B.-L., Zhou, Y., Zhang, C.-Y., Wang, H., Hu, B., Wang, P.-X., Te, L., Pan, B.-S., Zhou, J., Fan, J., Yang, X.-R., & Guo, W. (2020). BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity. Cell Death & Disease, 11(10), 1–13. https://doi.org/10.1038/s41419-020-03115-3 Cite
TRIM28 high level related to higher melanoma stemness as measured with several distinct scores and TRIM28HIGH-expressing melanoma cell lines possess the greater potential of melanosphere formation.
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Scientists compared transplantation of human CD34+ HSPCs purified from three different sources: umbilical cord blood, adult bone marrow, and adult G-CSF mobilized peripheral blood.
[Frontiers in Immunology]
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Hess, N. J., Lindner, P. N., Vazquez, J., Grindel, S., Hudson, A. W., Stanic, A. K., Ikeda, A., Hematti, P., & Gumperz, J. E. (2020). Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.573406 Cite
Forty-three subjects with B-cell acute lymphoblastic leukemia relapsing post allotransplant received CAR-T cells were analyzed.
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Zhang, C., Wang, X.-Q., Zhang, R.-L., Liu, F., Wang, Y., Yan, Z.-L., Song, Y.-P., Yang, T., Li, P., Wang, Z., Ma, Y.-Y., Gao, L., Liu, Y., Gao, L., Kong, P.-Y., Liu, J., Tan, X., Zhong, J. F., Chen, Y.-Q., … Zhang, X. (2020). Donor-derived CD19 CAR-T cell therapy of relapse of CD19-positive B-ALL post allotransplant. Leukemia, 1–8. https://doi.org/10.1038/s41375-020-01056-6 Cite
Investigators observed that plasmacytoma variant translocation 1 (PVT1) and caspase‐10 were upregulated while miR‐23a‐3p was downregulated in high glucose‐induced cardiomyocytes. High glucose repressed cardiomyocyte activity and induced cardiomyocyte apoptosis, but this influence was antagonized by PVT1 knockdown or miR‐23a‐3p overexpression.
[Cell Biology International]
Scientists showed changes in the abundance and activation states of more than 50 immune cell subsets in 35 individuals over 11 time points during human A/California/2009 (H1N1) virus challenge monitored using mass cytometry along with other clinical assessments.
[Journal of Clinical Investigation]
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Rahil, Z., Leylek, R., Schürch, C. M., Chen, H., Bjornson-Hooper, Z., Christensen, S. R., Gherardini, P. F., Bhate, S. S., Spitzer, M. H., Fragiadakis, G. K., Mukherjee, N., Kim, N., Jiang, S., Yo, J., Gaudilliere, B., Affrime, M., Bock, B., Hensley, S. E., Idoyaga, J., … McIlwain, D. R. (2020). Landscape of coordinated immune responses to H1N1 challenge in humans. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI137265 Cite