Distinct Antibody and Memory B Cell Responses in SARS-CoV-2 Naïve and Recovered Individuals Following mRNA Vaccination

Researchers showed that the SARS-CoV-2 envelope protein alone is able to cause acute respiratory distress syndrome-like damages in vitro and in vivo.
[Science Immunology]
Goel, R. R., Apostolidis, S. A., Painter, M. M., Mathew, D., Pattekar, A., Kuthuru, O., Gouma, S., Hicks, P., Meng, W., Rosenfeld, A. M., Dysinger, S., Lundgreen, K. A., Kuri-Cervantes, L., Adamski, S., Hicks, A., Korte, S., Oldridge, D. A., Baxter, A. E., Giles, J. R., … Wherry, E. J. (2021). Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination. Science Immunology, 6(58). https://doi.org/10.1126/sciimmunol.abi6950 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Memory B Cells Targeting SARS-CoV-2 Spike Protein and Their Dependence on CD4+ T Cell Help

Scientists investigated SARS-CoV-2 spike-specific memory B cells and their dependence on CD4+ T cell help in different settings of COVID-19.
[Cell Reports]
Pušnik, J., Richter, E., Schulte, B., Dolscheid-Pommerich, R., Bode, C., Putensen, C., Hartmann, G., Alter, G., & Streeck, H. (2021). Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2021.109320 Cite
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer

A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.
[Clinical Cancer Research]
Carter, J. M., Polley, M.-Y. C., Leon-Ferre, R. A., Sinnwell, J., Thompson, K. J., Wang, X., Ma, Y., Zahrieh, D., Kachergus, J. M., Solanki, M., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Thompson, E. A., & Goetz, M. P. (2021). Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0343 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib

B cells may serve as a potential biomarker to predict clinical outcome in patients with advanced melanoma treated with dabrafenib plus trametinib.
[Clinical Cancer Research]
Brase, J. C., Walter, R. F. H., Savchenko, A., Gusenleitner, D., Garrett, J., Schimming, T. T., Váraljai, R., Castelletti, D., Kim, J.-Y., Dakappagari, N. K., Schultz, K., Robert, C., Long, G. V., Nathan, P. D., Ribas, A., Flaherty, K. T., Karaszewska, B., Schachter, J., Sucker, A., … Roesch, A. (2021). Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3586 Cite
Abstract
Bookmark

No account yet? Register

0
Share

The Dynamic Epigenetic Regulation of the Inactive X Chromosome in Healthy Human B Cells Is Dysregulated in Lupus Patients

Scientists used RNA fluorescence in situ hybridization and immunofluorescence to profile epigenetic features of the inactive X at the single-cell level in human B cell subsets from pediatric and adult systemic lupus erythematous patients and healthy controls.
[Proceedings of the National Academy of Sciences of the United States of America]
Pyfrom, S., Paneru, B., Knox, J. J., Cancro, M. P., Posso, S., Buckner, J. H., & Anguera, M. C. (2021). The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients. Proceedings of the National Academy of Sciences, 118(24). https://doi.org/10.1073/pnas.2024624118 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Insulin Resistance Is Linked to a Specific Profile of Immune Activation in Human Subjects

Researchers tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. By measuring 43 markers of immune, endothelial, and coagulation activation, we have previously shown that five different immune activation profiles may be distinguished in 150 volunteers.
[Scientific Reports]
Cezar, R., Desigaud, D., Pastore, M., Kundura, L., Dupuy, A.-M., Cognot, C., Vincent, T., Reynes, C., Sabatier, R., Maggia, E., & Corbeau, P. (2021). Insulin resistance is linked to a specific profile of immune activation in human subjects. Scientific Reports, 11(1), 12314. https://doi.org/10.1038/s41598-021-91758-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Signaling Pathways in Cancer-Associated Fibroblasts and Targeted Therapy for Cancer

Scientists summarize the enormous amounts of findings on the signals mediating crosstalk of cancer-associated fibroblasts with cancer cells and its related targets or trials.
[Signal Transduction and Targeted Therapy]
Full Article
Bookmark

No account yet? Register

0
Share

Therapeutic Vaccine for Chronic Diseases after the COVID-19 Era

After the COVID-19 era, the novel vaccine technology developed will expand to other vaccines. Scientists have been developing vaccines for chronic diseases, such as hypertension, for over ten years.
[Hypertension Research]
Nakagami, H., Hayashi, H., Shimamura, M., Rakugi, H., & Morishita, R. (2021). Therapeutic vaccine for chronic diseases after the COVID-19 Era. Hypertension Research, 1–7. https://doi.org/10.1038/s41440-021-00677-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

CART-Cell Therapy: Recent Advances and New Evidence in Multiple Myeloma

The authors describe several recent advances in the field of anti-B-cell maturation antigen CAR T-cell therapy and multiple myeloma.
[Cancers]
Full Article
Bookmark

No account yet? Register

0
Share

Heterogeneity of Meningeal B Cells Reveals a Lymphopoietic Niche at the CNS Borders

B cells reached the meninges from the calvaria through specialized vascular connections. This calvarial–meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens.
[Science]
Brioschi, S., Wang, W.-L., Peng, V., Wang, M., Shchukina, I., Greenberg, Z. J., Bando, J. K., Jaeger, N., Czepielewski, R. S., Swain, A., Mogilenko, D. A., Beatty, W. L., Bayguinov, P., Fitzpatrick, J. A. J., Schuettpelz, L. G., Fronick, C. C., Smirnov, I., Kipnis, J., Shapiro, V. S., … Colonna, M. (2021). Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science. https://doi.org/10.1126/science.abf9277 Cite
AbstractPress Release
Bookmark

No account yet? Register

0
Share

Lung-Resident Memory B Cells Protect against Bacterial Pneumonia

Investigators examined whether lung lung-resident memory B cells cells were elicited by the respiratory pathogen pneumococcus, were present in humans, and were important in pneumonia defense
[Journal of Clinical Investigation]
Barker, K. A., Etesami, N. S., Shenoy, A. T., Arafa, E. I., Ana, C. L. de, Smith, N. M. S., Martin, I. M. C., Goltry, W. N., Barron, A. M. S., Browning, J. L., Kathuria, H., Belkina, A. C., Guillon, A., Zhong, X., Crossland, N. A., Jones, M. R., Quinton, L. J., & Mizgerd, J. P. (2021). Lung-resident memory B cells protect against bacterial pneumonia. The Journal of Clinical Investigation, 131(11). https://doi.org/10.1172/JCI141810 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share