Investigators performed single-cell RNA sequencing in peripheral blood samples of five healthy donors and 13 patients with COVID-19, including moderate, severe and convalescent cases.
6445212 B6BC6HTB items 1 apa default asc 1
Zhang, J.-Y., Wang, X.-M., Xing, X., Xu, Z., Zhang, C., Song, J.-W., Fan, X., Xia, P., Fu, J.-L., Wang, S.-Y., Xu, R.-N., Dai, X.-P., Shi, L., Huang, L., Jiang, T.-J., Shi, M., Zhang, Y., Zumla, A., Maeurer, M., … Wang, F.-S. (2020). Single-cell landscape of immunological responses in patients with COVID-19. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0762-x Cite
Celyad Oncology SA announced that the company’s Investigational New Drug (IND) application for CYAD-211, the company’s first-in-class short hairpin RNA-based allogeneic CAR T candidate and second non-gene edited off-the-shelf program, is in effect with the FDA.
[Celyad Oncology SA]
Using mouse models of multiple scelrosis, investigators determined that evobrutinib, the first Burton’s tyrosine kinase inhibiting molecule being developed, dose-dependently inhibited antigen-triggered activation and maturation of B cells as well as their release of pro-inflammatory cytokines.
6445212 DUU6UAXQ items 1 apa default asc 1
Torke, S., Pretzsch, R., Häusler, D., Haselmayer, P., Grenningloh, R., Boschert, U., Brück, W., & Weber, M. S. (2020). Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease. Acta Neuropathologica. https://doi.org/10.1007/s00401-020-02204-z Cite
Scientists report that B cell-specific deletion of the X-linked gene, Cosmc, and the consequent decrease of protein O-glycosylation, induced developmental blocks of mouse B cells.
6445212 R8DAF69L items 1 apa default asc 1
Scientists investigated B cell fate programming and heterogeneity during anti-body secreting cells (ASCs) differentiation using T cell-independent models. They found that maximal ASC induction required at least eight cell divisions in vivo, with BLIMP-1 being required for differentiation at division eight.
6445212 EKETGVWZ items 1 apa default asc 1
The authors report the first evidence that the gut-homing chemokine receptor CCR10+ IgA antibody-secreting B cells formed conjugates with helper T cells, preferentially regulatory T cells, at their differentiation sites of gut-associated lymphoid organs for their coordinated co-localization into the colon to promote local homeostasis.
6445212 2FLVKFFG items 1 apa default asc 1
Zhao, L., Hu, S., Davila, M. L., Yang, J., Lin, Y.-D., Albanese, J. M., Lo, Y., Wang, Y., Kennett, M. J., Liu, Q., & Xiong, N. (2020). Coordinated co-migration of CCR10 + antibody-producing B cells with helper T cells for colonic homeostatic regulation. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-020-0333-3 Cite
Vaccine-induced antibodies exhibited a high degree of clonal diversity, recognized five conformational antigenic sites of the genotype 1 HEV p239 antigen, and cross-reacted with other genotypes.
6445212 HR78HTBG items 1 apa default asc 1
Wen, G.-P., He, L., Tang, Z.-M., Wang, S.-L., Zhang, X., Chen, Y.-Z., Lin, X., Liu, C., Chen, J.-X., Ying, D., Chen, Z.-H., Wang, Y.-B., Luo, W.-X., Huang, S.-J., Li, S.-W., Zhang, J., Zheng, Z.-Z., Zhu, J., & Xia, N.-S. (2020). Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans. Nature Communications, 11(1), 3971. https://doi.org/10.1038/s41467-020-17737-w Cite
Data sets revealed that B cells in the blood were not in homeostasis with compartments in other tissues. Investigators found striking donor-to-donor variability in the frequencies and isotype of CD27+ memory B cells
6445212 5R6BUP4V items 1 apa default asc 1
Investigators report here that IL-17A mRNA and protein were detectable in some human triple-negative breast cancer cell lines and further upregulated by IL-23 and LPS stimulation.
6445212 PE7DFFXH items 1 apa default asc 1
Dawod, B., Liu, J., Gebremeskel, S., Yan, C., Sappong, A., Johnston, B., Hoskin, D. W., Marshall, J. S., & Wang, J. (2020). Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas. Scientific Reports, 10(1), 13343. https://doi.org/10.1038/s41598-020-70231-7 Cite
By employing single-cell analysis of the immune cell composition of two severe-stage COVID-19 patients prior to and following tocilizumab-induced remission, investigators identified a monocyte subpopulation that contributes to the inflammatory cytokine storms.
6445212 BKTLULRK items 1 apa default asc 1
Guo, C., Li, B., Ma, H., Wang, X., Cai, P., Yu, Q., Zhu, L., Jin, L., Jiang, C., Fang, J., Liu, Q., Zong, D., Zhang, W., Lu, Y., Li, K., Gao, X., Fu, B., Liu, L., Ma, X., … Qu, K. (2020). Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm. Nature Communications, 11(1), 3924. https://doi.org/10.1038/s41467-020-17834-w Cite
Purified B cells from such patients generated more IL-35 after stimulation by antigens of Mycobacterium tuberculosis and secreted more IL-10.
6445212 VNCIFDCZ items 1 apa default asc 1
Chen, C., Xu, H., Peng, Y., Luo, H., Huang, G.-X., Wu, X.-J., Dai, Y.-C., Luo, H.-L., Zhang, J.-A., Zheng, B.-Y., Zhang, X.-N., Chen, Z. W., & Xu, J.-F. (2020). Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3 + Treg. Scientific Reports, 10(1), 13212. https://doi.org/10.1038/s41598-020-69984-y Cite
Continue reading “Elevation in the Counts of IL-35-Producing B Cells Infiltrating into Lung Tissue in Mycobacterial Infection Is Associated with the Downregulation of Th1/Th17 and Upregulation of Foxp3+Treg”
Scientists treated 14 relapsed or refractory diffuse large B-cell lymphoma patients by combining autologous hematopoietic stem cell transplantation and anti-CD19 chimeric antigen receptor T-cell therapy.
1254621 7W99HMR7 items 1 apa default asc 1
Wang, T., Gao, L., Wang, Y., Zhu, W., Xu, L., Wang, Y., Yue, W., Tang, G., Chen, L., Chen, J., Zhang, W., Yu, X., Feng, D., & Yang, J. (2020). Hematopoietic stem cell transplantation and chimeric antigen receptor T cell for relapsed or refractory diffuse large B-cell lymphoma. Immunotherapy. https://doi.org/10.2217/imt-2020-0075 Cite