Neurofilament Light Chain Serum Levels Correlate with the Severity of Neurotoxicity after CAR T Cell Treatment

Researchers examined whether serum levels of neurofilament light chain, a marker of neuroaxonal injury, correlated with the severity of immune effector cell-associated neurotoxicity syndrome.
[Blood Advances]
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IMV Announces First Patient Dosed in the VITALIZE Phase IIB Clinical Study Evaluating its Lead Compound, MVP-S, in Combination with KEYTRUDA® (pembrolizumab) in Patients with r/r DLBCL

IMV, Inc., a clinical-stage company developing a portfolio of immune-educating therapies based on its novel DPX platform to treat solid and hematologic cancers, announced a first patient dosed in the VITALIZE Phase IIB clinical trial.
[IMV Inc.]
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HUTCHMED Receives Breakthrough Therapy Designation in China for HMPL-523 for Treatment of Primary Immune Thrombocytopenia

HUTCHMED Limited announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation to HMPL-523, a novel, investigational spleen tyrosine kinase inhibitor, for the treatment of chronic adult primary immune thrombocytopenia patients who have received at least one prior therapy.
[HUTCHMED Limited (Globe Newswire, Inc.)]
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Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma

Investigators quantified tumor infiltration across two distinct clear cell renal cell carcinoma patient tumor cohorts using complementarity determining region-3 (CDR3) sequence recovery counts in tumor-infiltrating lymphocytes and a generalized diversity index for CDR3 sequence distributions.
[Cancer Research]
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CD19/BAFF-R Dual-Targeted CAR T Cells for the Treatment of Mixed Antigen-Negative Variants of Acute Lymphoblastic Leukemia

To mitigate antigen escape and potentially improve the durability of remission, scientists developed a dual-targeting approach using an optimized, bispecific CAR construct that targets both CD19 and BAFF-R.
[Leukemia]
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Development of the Immune System in the Human Embryo

Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors.
[Pediatric Research]
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The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes

Researchers generated a NOD congenic mouse bearing B10 resistance alleles on chromosome 9 in a locus coinciding with part of the insulin-dependent diabetes (Idd) locus and found that NOD.
[Journal of Immunology]
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Synergistic Activity of Combined Inhibition of Anti-apoptotic Molecules in B-cell Precursor ALL

When analyzing the effects of BH3-mimetics selectively targeting BCL-XL and MCL-1 alone or in combination with the BCL-2 inhibitor venetoclax, heterogeneous sensitivity to either of these inhibitors was found in ALL cell lines and in patient-derived xenografts.
[Leukemia]
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IL-13Rα2 Humanized scFv-Based CAR T Cells Exhibit Therapeutic Activity against Glioblastoma with Increased Expansion and Reduced Cytokine Production

Investigators constructed a CAR targeting interleukin-13 receptor α2 according to a murine antibody, and then humanized the single-chain variable fragment sequence to generate another CAR.
[Molecular Therapy-Oncolytics]
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A Subset of Follicular Helper-Like MAIT Cells Can Provide B Cell Help and Support Antibody Production in the Mucosa

Scientists described a population of CXCR5+ T follicular helper–like mucosal-associated invariant T (MAIT) cells that have the capacity to provide B cell help within mucosal lymphoid organs.
[Science Immunology]
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CD169+ Macrophages in Lymph Node and Spleen Critically Depend on Dual RANK and LTbetaR Signaling

The authors demonstrated that lymph node CD169+ macrophages were dependent on direct lymphotoxin beta receptor signaling.
[Proceedings of the National Academy of Sciences of the United States of America]
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