Evolving Insights into the Genomic Complexity and Immune Landscape of Diffuse Large B-Cell Lymphoma: Opportunities for Novel Biomarkers

The authors highlight the newly reported heterogeneous mutational landscapes of diffuse large B-cell lymphoma from two whole-exome sequencing studies, and from a more recent work targeting a 293-gene of a hematologic malignancy-designed panel.
[Modern Pathology]
El Hussein, S., Shaw, K. R. M., & Vega, F. (2020). Evolving insights into the genomic complexity and immune landscape of diffuse large B-cell lymphoma: opportunities for novel biomarkers. Modern Pathology, 1–15. https://doi.org/10.1038/s41379-020-0616-y Cite
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Role of Nanoscale Antigen Organization on B-Cell Activation Probed Using DNA Origami

To independently probe the relative roles of immunogen valency and spacing on immunoglobulin-M-B cell receptor activation, investigators used scaffolded DNA origami NPs17,18,19 to display discrete antigen copy numbers with controlled inter-antigen spacings on the scale of an individual virus-like nanoparticles.
[Nature Nanotechnology]
Veneziano, R., Moyer, T. J., Stone, M. B., Wamhoff, E.-C., Read, B. J., Mukherjee, S., … Bathe, M. (2020). Role of nanoscale antigen organization on B-cell activation probed using DNA origami. Nature Nanotechnology, 1–8. https://doi.org/10.1038/s41565-020-0719-0 Cite
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Safety and Efficacy of Chimeric Antigen Receptor (CAR)-T-cell Therapy in Persons with Advanced B-Cell Cancers and Hepatitis B Virus-Infection

Scientists studied 70 subjects with advanced B-cell cancers receiving CAR-T-cell therapy, 12 of whom had chronic hepatitis B virus-infection (HBV) and 29 with resolved HBV-infection
[Leukemia]
Wang, Y., Liu, Y., Tan, X., Pan, B., Ge, J., Qi, K., … Xu, K. (2020). Safety and efficacy of chimeric antigen receptor (CAR)-T-cell therapy in persons with advanced B-cell cancers and hepatitis B virus-infection. Leukemia, 1–4. https://doi.org/10.1038/s41375-020-0936-4 Cite
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The Transcription Factor Hhex Cooperates with the Corepressor Tle3 to Promote Memory B Cell Development

Using single-cell RNA sequencing analysis, the authors identified a population of germinal center B cells in the process of differentiating into memory B cells.
[Nature Immunology]
Laidlaw, B. J., Duan, L., Xu, Y., Vazquez, S. E., & Cyster, J. G. (2020). The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0713-6 Cite
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Gut Dysbiosis Modulates the Immune Response to Factor VIII in Murine Hemophilia A

Investigators demonstrate that a disrupted gut microbiota could be created in a mouse model of hemophilia A using a broad-spectrum antibiotic.
[Blood Advances]
Tarrant, J., Cormier, M., Nesbitt, K., Dwyer, C., Hough, C., & Lillicrap, D. (2020). Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A. Blood Advances, 4(12), 2644–2655. https://doi.org/10.1182/bloodadvances.2019001144 Cite
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Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39−CD73 Signaling Pathway

Gingiva derived-mesenchymal stem cells limited the development of autoantibodies as well as proteinuria, decreases the frequency of plasma cells and lupus nephritis histopathological scores by directly suppressing B cells activation, proliferation and differentiation.
[Journal of Autoimmunity]
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BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor–Mediated Calcium Signaling

lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.
[Journal of Immunology]
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Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome

The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.
[Arthritis Research & Therapy]
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Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
[Oncogene]
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Different Impact of Calreticulin Mutations on Human Hematopoiesis in Myeloproliferative Neoplasms

Mutations of calreticulin were associated with an early clonal dominance at the level of hematopoietic stem and progenitor cells with no significant increase during granulo/monocytic differentiation in most cases.
[Oncogene]
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Generation of Knockout Rabbits with X-Linked Severe Combined Immunodeficiency (X-SCID) Using CRISPR/Cas9

X-SCID rabbits presented immunodeficient phenotypes including the loss of T and B cells and hypoplasia of the thymus.
[Scientific Reports]
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