Flowcytometry in Reactive Lymph Node Aspirates: Evaluation of Distribution of Populations with Immunophenotypic Outliers

Flowcytometry of FNA/ scrape material from 30 cases of benign lymph nodes was evaluated to study the distribution of lymphoid populations and assess presence and percentages of immunophenotypic outliers.
[Cytopathology]
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HLA-Independent T Cell Receptors for Targeting Tumors with Low Antigen Density

The authors edited the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor–CD3 complex reconfigured to utilize the same immunoglobulin heavy and light chains as a matched CAR.
[Nature Medicine]
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Hypoxia-Inducible Factor 1α Induces Osteo/Odontoblast Differentiation of Human Dental Pulp Stem Cells via Wnt/β-Catenin Transcriptional Cofactor BCL9

The authors examined the role of B-cell CLL/lymphoma 9 (BCL9), which is downstream of hypoxia-inducible factor 1α and a Wnt/β-catenin transcriptional cofactor, in the osteo/odontoblastic differentiation of human dental pulp stem cells under hypoxic conditions.
[Scientific Reports]
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Sana Biotechnology Obtains Exclusive License from National Institutes of Health for CD22 CAR Construct

Sana Biotechnology, Inc. announced that the company entered into an agreement with the National Cancer Institution, an institute of the National Institutes of Health, for worldwide exclusive commercial rights to the NIH’s CD22 CAR with a fully-human binder for use in certain in vivo gene therapy and ex vivo allogeneic CAR T applications for B cell malignancies.
[Sana Biotechnology, Inc.]
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B Cells Imprint Adoptively Transferred CD8+ T Cells with Enhanced Tumor Immunity

Researchers investigated how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes were impacted when expanded ex vivo with the TLR9 agonist CpG.
[Journal For Immunotherapy of Cancer]
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Knockdown of Zinc Finger Protein 267 Suppresses Diffuse Large B-cell Lymphoma Progression, Metastasis, and Cancer Stem Cell Properties

Scientist found ZNF267 was significantly upregulated in diffuse large B-cell lymphoma and predicted a poor survival outcome based on the bioinformatics analysis.
[Bioengineered]
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A BAFF Ligand-Based CAR-T Cell Targeting Three Receptors and Multiple B Cell Cancers

Investigators developed a B cell-activating factor (BAFF) ligand-based CAR and generated BAFF CAR-T cells using a non-viral gene delivery method.
[Nature Communications]
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How to Induce Protective Humoral Immunity against Plasmodium falciparum Circumsporozoite Protein

Scientists review recent efforts to gain a better molecular and cellular understanding of anti-Plasmodium falciparum circumsporozoite protein B cell responses in humans and discuss ways to overcome limitations in the induction of stable titers of high-affinity antibodies.
[Journal of Experimental Medicine]
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Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients with Different Severities

According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.
[Frontiers in Immunology]
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T Cell Receptor Beta Germline Variability Is Revealed by Inference from Repertoire Data

Scientists adapted a B cell pipeline for undocumented alleles, genotype, and haplotype inference for full and partial adaptive immune receptor repertoire sequencing T cell receptor data sets.
[Genome Medicine]
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A Virus-Specific Monocyte Inflammatory Phenotype Is Induced by SARS-CoV-2 at the Immune–Epithelial Interface

A strong response was induced in monocytes and B cells, with a SARS-CoV-2–specific inflammatory gene cluster distinct from that seen in influenza A or Ebola virus-infected cocultures, and which reproduced deviations reported in blood or lung myeloid cells from COVID-19 patients.
[Proceedings of the National Academy of Sciences of the United States of America]
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