Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells

Investigators studied CD4+ T cells in a mouse model with regulatable antigen presentation.
[Cell Reports]
Trefzer, A., Kadam, P., Wang, S.-H., Pennavaria, S., Lober, B., Akçabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., & Obst, R. (2021). Dynamic adoption of anergy by antigen-exhausted CD4+ T cells. Cell Reports, 34(6). https://doi.org/10.1016/j.celrep.2021.108748 Cite
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Mediator Subunit MED1 Is Required for E2A-PBX1–Mediated Oncogenic Transcription and Leukemic Cell Growth

The authors showed that Mediator interacted directly with E2A-PBX1 through an interaction of the MED1 subunit with an E2A activation domain. Results of MED1 depletion by CRISPR/Cas9 further indicated that MED1 was specifically required for E2A-PBX1–dependent gene activation and leukemic cell growth.
[Proceedings of the National Academy of Sciences of the United States of America]
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Human Gut Mycobiota Tune Immunity via CARD9-Dependent Induction of Anti-fungal IgG Antibodies

Using a multi-kingdom antibody profiling approach, researchers explored the human antibody repertoires against gut commensal fungi.
[Cell]
Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies: Cell. (n.d.). Retrieved February 8, 2021, from https://www.cell.com/cell/fulltext/S0092-8674(21)00059-3 Cite
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Distinct Organization of Adaptive Immunity in the Long-Lived Rodent Spalax galili

Scientists uncovered distinctive features of the long-lived blind mole-rat adaptive immune system, relative to humans and mice.
[Nature Aging]
Izraelson, M., Metsger, M., Davydov, A. N., Shagina, I. A., Dronina, M. A., Obraztsova, A. S., Miskevich, D. A., Mamedov, I. Z., Volchkova, L. N., Nakonechnaya, T. O., Shugay, M., Bolotin, D. A., Staroverov, D. B., Sharonov, G. V., Kondratyuk, E. Y., Zagaynova, E. V., Lukyanov, S., Shams, I., Britanova, O. V., & Chudakov, D. M. (2021). Distinct organization of adaptive immunity in the long-lived rodent Spalax galili. Nature Aging, 1–11. https://doi.org/10.1038/s43587-021-00029-3 Cite
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BAFF Promotes Heightened BCR Responsiveness and Manifestations of Chronic GVHD after Allogeneic Stem Cell Transplantation

Chronic graft versus host disease manifestations in mice associated with high BAFF/B cell ratios and persistence of B cell receptor-activated B cells in peripheral blood and lesional tissue.
[Blood]
Jia, W., Poe, J. C., Su, H., Anand, S., Matsushima, G. K., Rathmell, J. C., Maillard, I., Radojcic, V., Imai, K., Reyes, N. J., Cardona, D. M., Li, Z., Suthers, A., Curry-Chisolm, I., DiCioccio, R. A., Saban, D. R., Chen, B. J., Chao, N. J., & Sarantopoulos, S. (2021). BAFF Promotes Heightened BCR Responsiveness and Manifestations of Chronic GVHD after Allogeneic Stem Cell Transplantation. Blood, blood.2020008040. https://doi.org/10.1182/blood.2020008040 Cite
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Infectious Triggers and Novel Therapeutic Opportunities in Childhood B Cell Leukaemia

The authors discuss the current understanding of the environmental triggers and genetic predispositions that may lead to B cell acute lymphoblastic leukaemia, highlighting lessons from epidemiology, the clinic and animal models, and identifying priority areas for future research.
[Nature Reviews Immunology]
Cobaleda, C., Vicente-Dueñas, C., & Sanchez-Garcia, I. (2021). Infectious triggers and novel therapeutic opportunities in childhood B cell leukaemia. Nature Reviews Immunology, 1–12. https://doi.org/10.1038/s41577-021-00505-2 Cite
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Clinical and Biological Subtypes of B-Cell Lymphoma Revealed by Microenvironmental Signatures

Researchers performed a transcriptomic analysis of the microenvironment of 4,655 DLBCLs from multiple independent cohorts and described four major lymphoma microenvironment categories that associate with distinct biological aberrations and clinical behavior.
[Cancer Discovery]
Kotlov, N., Bagaev, A., Revuelta, M. V., Phillip, J. M., Cacciapuoti, M. T., Antysheva, Z., Svekolkin, V., Tikhonova, E., Miheecheva, N., Kuzkina, N., Nos, G., Tabbo, F., Frenkel, F., Ghione, P., Tsiper, M., Almog, N., Fowler, N., Melnick, A. M., Leonard, J. P., … Cerchietti, L. (2021). Clinical and biological subtypes of B-cell lymphoma revealed by microenvironmental signatures. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0839 Cite
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Dual Targeting of MTOR as a Novel Therapeutic Approach for High-Risk B-Cell Acute Lymphoblastic Leukemia

Scientists report that IKAROS repressed MTOR transcription and IKAROS’ ability to repress MTOR in leukemia was impaired by oncogenic CK2 kinase.
[Leukemia]
Ge, Z., Song, C., Ding, Y., Tan, B.-H., Desai, D., Sharma, A., Gowda, R., Yue, F., Huang, S., Spiegelman, V., Payne, J. L., Reeves, M. E., Iyer, S., Dhanyamraju, P. K., Imamura, Y., Bogush, D., Bamme, Y., Yang, Y., Soliman, M., … Dovat, S. (2021). Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia. Leukemia, 1–12. https://doi.org/10.1038/s41375-021-01132-5 Cite
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Host Immunity Modulates the Efficacy of Microbiota Transplantation for Treatment of Clostridioides difficile Infection

Scientists demonstrated a critical role for the immune system in supporting fecal microbiota transplantation using a murine C. difficile infection system.
[Nature Communications]
Littmann, E. R., Lee, J.-J., Denny, J. E., Alam, Z., Maslanka, J. R., Zarin, I., Matsuda, R., Carter, R. A., Susac, B., Saffern, M. S., Fett, B., Mattei, L. M., Bittinger, K., & Abt, M. C. (2021). Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection. Nature Communications, 12(1), 755. https://doi.org/10.1038/s41467-020-20793-x Cite
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Abzena Selected by Immunome to Develop and Manufacture Antibody Cocktail for Immunome’s COVID-19 Antibody Based Treatment

Immunome, Inc. announced that Abzena was selected as Immunome’s partner research organization for IMM-BCP-01, an investigational therapeutic antibody cocktail for the treatment of COVID-19 being developed to target multiple SARS-CoV-2 antigens.
[Immunome, Inc. (BusinessWire, Inc)]
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Dynamic Regulation of TFH Selection during the Germinal Centre Reaction

Researchers report on the dynamic behaviour of T follicular helper cell clones during the germinal centre reaction.
[Nature]
Merkenschlager, J., Finkin, S., Ramos, V., Kraft, J., Cipolla, M., Nowosad, C. R., Hartweger, H., Zhang, W., Olinares, P. D. B., Gazumyan, A., Oliveira, T. Y., Chait, B. T., & Nussenzweig, M. C. (2021). Dynamic regulation of T FH selection during the germinal centre reaction. Nature, 1–6. https://doi.org/10.1038/s41586-021-03187-x Cite
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