B cells

[Human Gene Therapy] The authors discussed the development of viral and nonviral vectors used to generate CAR-T cells, focusing on their advantages and limitations.

[Journal of Experimental Medicine] Investigators described a novel combined immunodeficiency due to an IKZF3 mutation in a family presenting with T and B cell involvement, Pneumocystis jirovecii pneumonia, and/or chronic lymphocytic leukemia.

[Cell Reports] Scientists reported that lymphoma caused severe high endothelial venules (HEVs) regression in mouse models that phenocopied aggressive human B cell lymphomas, and that HEV dedifferentiation occurred as a consequence of a disrupted lymph-carrying conduit system.

[Cell Research] MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps, and promoted the maintenance of SARS-CoV-2-specific antibodies.

[Blood] The authors performed whole-genome sequencing of 150 adult T cell leukemia/lymphoma (ATL) cases and revealed the overarching landscape of genetic alterations in ATL.

[Blood] Researchers advanced the understanding of biological characteristics, improved disease stratification, and identified molecular targets of adult B cell acute lymphoblastic leukemia (B-ALL). They highlighted the age-dependent distribution of subtypes in prognostic differences between adult and pediatric B-ALL.