B cells

[US FDA] The FDA approved axicabtagene ciloleucel for adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or relapses within 12 months of first-line chemoimmunotherapy.

[Nature Reviews Clinical Oncology] Investigators review the phenotypic heterogeneity of intratumoral B cells and the importance of tertiary lymphoid structures (TLS) in their generation as well as the potential of B cells and TLS as prognostic and predictive biomarkers.

[Molecular Psychiatry] Researchers performed the largest transcriptome-wide association study for postpartum depressionto date using RNA-sequencing in whole blood and deconvoluted cell types.

[PLoS Pathogens] In both model systems, Mycobacterium tuberculosis (Mtb)-infected mice were resistant to the pathological consequences of secondary SARS-CoV-2 infection, and SARS-CoV-2 infection did not affect Mtb burdens.

[Journal of Immunology] Scientists showed that, in comparison with a pre-epidemic isolate infection of Zika virus (ZIKV), CD4 T cells were less polarized to the Th1 subtype following Brazilian ZIKV isolate challenge in mice.

[Frontiers in Immunology] Scientists examine the immunosuppressive features of the leukemia microenvironment, discuss how preclinical modeling help predict adoptive cell therapy (ACT) associated toxicities and dysfunction, and explore publications that have employed syngeneic modeling in ACT studies for the improvement of therapy for leukemias.