Adjuvanted H5N1 Influenza Vaccine Enhances Both Cross-Reactive Memory B Cell and Strain-Specific Naive B Cell Responses in Humans

Plasmablast response after the first immunization was exclusively directed to the conserved hemagglutinin stem region and came from memory B cells.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=’6445212′ items=’GAYYA9HA’ style=’apa’ cite=’yes’]
AbstractPress Release
Bookmark

No account yet? Register

Share

An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity

Scientists developed a highly multiplexed screen to quantify the co-expression of 351 surface molecules on millions of human B cells.
[Immunity]
[zotpress userid=’6445212′ items=’AM8XHNMJ’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Ageing Hallmarks Exhibit Organ-Specific Temporal Signatures

Researchers performed bulk RNA sequencing of 17 organs and plasma proteomics at ten ages across the lifespan of Mus musculus, and integrated these findings with data from the accompanying Tabula Muris Senis—or ‘Mouse Ageing Cell Atlas’—which followed on from the original Tabula Muris.
[Nature]
[zotpress userid=’6445212′ items=’HU66WCPW’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

PRDM15 Is a Key Regulator of Metabolism Critical to Sustain B-Cell Lymphomagenesis

Investigators demonstrated that while PRDM15 was largely dispensable for mouse adult somatic cell homeostasis in vivo, it played a critical role in B-cell lymphomagenesis.
[Nature Communications]
[zotpress userid=’6445212′ items=’RYP646WW’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Immunogenomic Landscape of Hematological Malignancies

Researchers integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally.
[Cancer Cell]
[zotpress userid=’1254621′ items=’VPBSC72E’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients

To identify SARS-CoV-2 neutralizing antibodies, the authors analyzed the antibody response of 12 COVID-19 patients from 8 to 69 days post diagnosis.
[Cell]
[zotpress userid=’1254621′ items=’RD739476′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Cholesterol Metabolism Drives Regulatory B Cell IL-10 through Provision of Geranylgeranyl Pyrophosphate

Researchers demonstrated that the induction of a regulatory program in human B cells was dependent on a metabolic priming event driven by cholesterol metabolism.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

Share

Evolving Insights into the Genomic Complexity and Immune Landscape of Diffuse Large B-Cell Lymphoma: Opportunities for Novel Biomarkers

The authors highlight the newly reported heterogeneous mutational landscapes of diffuse large B-cell lymphoma from two whole-exome sequencing studies, and from a more recent work targeting a 293-gene of a hematologic malignancy-designed panel.
[Modern Pathology]
[zotpress userid=’6445212′ items=’YV8RBMB2′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Role of Nanoscale Antigen Organization on B-Cell Activation Probed Using DNA Origami

To independently probe the relative roles of immunogen valency and spacing on immunoglobulin-M-B cell receptor activation, investigators used scaffolded DNA origami NPs17,18,19 to display discrete antigen copy numbers with controlled inter-antigen spacings on the scale of an individual virus-like nanoparticles.
[Nature Nanotechnology]
[zotpress userid=’6445212′ items=’Z8I4BIC5′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Safety and Efficacy of Chimeric Antigen Receptor (CAR)-T-cell Therapy in Persons with Advanced B-Cell Cancers and Hepatitis B Virus-Infection

Scientists studied 70 subjects with advanced B-cell cancers receiving CAR-T-cell therapy, 12 of whom had chronic hepatitis B virus-infection (HBV) and 29 with resolved HBV-infection
[Leukemia]
[zotpress userid=’6445212′ items=’UN93VFWN’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

The Transcription Factor Hhex Cooperates with the Corepressor Tle3 to Promote Memory B Cell Development

Using single-cell RNA sequencing analysis, the authors identified a population of germinal center B cells in the process of differentiating into memory B cells.
[Nature Immunology]
[zotpress userid=’6445212′ items=’BBZCMLIS’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share