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B cells

Reduced Dose of PTCy Followed by Adjuvant α-Galactosylceramide Enhances GVL Effect without Sacrificing GVHD Suppression

[Scientific Reports] Researchers investigated the effects of reducing the dose of posttransplantation cyclophosphamide (PTCy) followed by α-galactosylceramide, a ligand of iNKT cells, on the reciprocal balance between graft-versus-host disease (GVHD) and the graft-versus-leukemia (GVL) effect.

Characterization of GECPAR, a Noncoding RNA That Regulates the Transcriptional Program of Diffuse Large B Cell Lymphoma

[Haematologica] Using diffuse large B cell lymphoma cell line models, the authors demonstrated the tumor suppressor activity of Germinal Center Proliferative Adapter RNA (GECPAR), which was mediated via its transcriptional regulation of proliferation and differentiation genes, particularly MYC and the Wnt pathways.

HUYABIO International Receives Regulatory Approval for HBI-8000 Monotherapy of Adult T-Cell Leukemia/Lymphoma in Japan

[HUYABIO InternationalTM (PR Newswire, Inc.)] HUYABIO International™ announced the regulatory approval for HBI-8000 monotherapy of relapsed or refractory adult T-cell leukemia/lymphoma (ATL) by the Japanese Pharmaceuticals and Medical Devices Agency. The drug was approved based on data from a Phase IIb study that involved 23 patients with aggressive ATL in Japan.

Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults with Relapsed or Refractory Acute Lymphoblastic Leukemia

[Journal of Clinical Oncology] Investigators conducted a pilot clinical trial of a humanized CD19 CAR T-cell product in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia or B-lymphoblastic lymphoma, treated in two cohorts: with or without prior CAR exposure.

Follicular Lymphoma Triggers Phenotypic and Functional Remodeling of the Human Lymphoid Stromal Cell Landscape

[Immunity] Researchers examined the effect of B cell stimuli on lymphoid stromal cells in follicular lymphoma (FL). FL B cells interacted primarily with CD49a+ fibroblastic reticular cells.

Canonical Features of Human Antibodies Recognizing the Influenza Hemagglutinin Trimer Interface

[Journal of Clinical Investigation] Scientists described common genetic and structural features of protective human antibodies from several individuals recognizing the trimer interface of the influenza A hemagglutinin head, a recently identified site of vulnerability.

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