The authors provides a comprehensive summary of the processes regulated by tumor-associated cells that promote the immune escape of melanoma cells.
[International Journal of Molecular Sciences]
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Researchers examined immune cell subsets in hospitalized and non-hospitalized individuals. In hospitalized patients, many adaptive and innate immune cells were decreased in frequency compared to healthy and convalescent individuals, with the exception of B lymphocytes which increased
[Journal of Clinical Investigation]
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Files, J. K., Boppana, S., Perez, M. D., Sarkar, S., Lowman, K. E., Qin, K., Sterrett, S., Carlin, E., Bansal, A., Sabbaj, S., Long, D. M., Kutsch, O., Kobie, J., Goepfert, P., & Erdmann, N. (2020). Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140491 Cite
Researchers hypothesized that head and neck squamous cell carcinoma recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.
[Clinical Cancer Research]
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Watermann, C., Pasternack, H., Idel, C., Ribbat-Idel, J., Brägelmann, J., Kuppler, P., Offermann, A., Jonigk, D., Kühnel, M., Schröck, A., Dreyer, E., Rosero, C., Nathansen, J., Dubrovska, A., Tharun, L., Kirfel, J., Wollenberg, B., Perner, S., & Krupar, R. (2020). Recurrent HNSCC harbor an immunosuppressive tumor immune microenvironment suggesting successful tumor immune evasion. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-0197 Cite
Researchers characterized the gastric mucosal inflammatory response associated with gastric MALT lymphoma (GML) and identified APRIL-producing cells in two model systems: an APRIL transgenic mouse model of GML induced by Helicobacter infection and human gastric biopsy samples from Helicobacter pylori-infected GML patients.
Both LPS stimulation of isolated B lymphocytes in vitro and TNP-LPS challenge in vivo led to significantly higher plasma cell formation and antibodies production in β-arr2−/− mice as compared with WT mice.
[Acta Pharmacologica Sinica]
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Zhou, W., Wang, D., Tao, J., Tai, Y., Zhou, Z., Wang, Z., Guo, P., Sun, W., Chen, J., Wu, H., Yan, S., Zhang, L., Wang, Q., & Wei, W. (2020). Deficiency of β-arrestin2 exacerbates inflammatory arthritis by facilitating plasma cell formation. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-020-00507-1 Cite
Monoclonal antibodies against CD4-1 and CD4-2 of flounder were produced, CD4+ T lymphocytes were isolated and identified, and the variations in CD4+ and CD8+ T lymphocytes and IgM+ B lymphocytes after Poly I:C, PMA or β-glucan stimulation were investigated.
C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
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Scientists aimed to determine whether the changes found in peripheral blood parameters were related to migraine severity according to the standardised MIDAS and HIT-6 tests.
Treatment‐naïve patients with metastatic colorectal cancer were assessed for CD8+ tumor-infiltrating lymphocutes and PD‐L1 expression. Microsatellite instability was evaluated by IHC for PMS2 and MSH6 proteins and/or by PCR using the Bethesda panel.
[Clinical & Translational Immunology]
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Millen, R., Hendry, S., Narasimhan, V., Abbott, R., Croxford, M., Gibbs, P., Tie, J., Wong, H.-L., Jones, I., Kosmider, S., Byrne, D., Zalcberg, J., Fox, S., Desai, J., Visvanathan, K., Ramsay, R. G., & Tran, B. (2020). CD8+ tumor-infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival. Clinical & Translational Immunology, 9(7), e1155. https://doi.org/10.1002/cti2.1155 Cite
Tissue microarray blocks were constructed and stained immunohistochemically using CD73 antibody. Staining intensity and numbers of stained tumor cells, inflammatory cells, stroma, and blood vessels were assessed.
Using a transgenic steroidogenesis-reporter mouse line the authors identified and characterized de novo steroidogenic immune cells, defining the global gene expression identity of these steroid-producing immune cells and gene regulatory networks by using single-cell transcriptomics.
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Mahata, B., Pramanik, J., van der Weyden, L., Polanski, K., Kar, G., Riedel, A., Chen, X., Fonseca, N. A., Kundu, K., Campos, L. S., Ryder, E., Duddy, G., Walczak, I., Okkenhaug, K., Adams, D. J., Shields, J. D., & Teichmann, S. A. (2020). Tumors induce de novo steroid biosynthesis in T cells to evade immunity. Nature Communications, 11(1), 3588. https://doi.org/10.1038/s41467-020-17339-6 Cite