Differential Levels of mRNAs in Normal B Lymphocytes, Monoclonal B Lymphocytosis and Chronic Lymphocytic Leukemia Cells from the Same Family Identify Susceptibility Genes

Researchers hypothesized that progressive changes in gene expression resulted in malignant transformation of B lymphocytes to family histroy of monoclonal B lymphocytosis, and subsequent alterations in gene expression occur before overt family history of chronic lymphocytic leukemia develops.
[Oncology and Therapy]
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Blood and Immune Development in Human Fetal Bone Marrow and Down Syndrome

Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.
[Nature]
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MicroRNA Regulation of B Cell Receptor Signaling

The authors focus on the role of miRNAs in the regulation of B cell receptor signaling as it pertains to B lymphocyte development and function.
[Immunological Reviews]
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EBNA2 Driven Enhancer Switching at the CIITA-DEXI Locus Suppresses HLA Class II Gene Expression during EBV Infection of B-Lymphocytes

Investigators identified a major EBNA2 binding site downstream of the CIITA gene and upstream of DEXI, a dexamethasone inducible gene that is oriented head-to-head with CIITA gene transcripts.
[PLOS Pathogens]
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LRRK2 Is Required for CD38-Mediated NAADP-Ca2+ Signaling and the Downstream Activation of TFEB (Transcription Factor EB) in Immune Cells

Researchers mechanistically and functionally linked CD38 and LRRK2 as upstream activators of TFEB, a host defense transcription factor and the master transcriptional regulator of the autophagy/lysosome machinery.
[Autophagy]
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Pax5 Regulates B Cell Immunity by Promoting PI3K Signaling via PTEN Down-Regulation

Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.
[Science Immunology]
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Peripheral B-Cells Repress B-Cell Regeneration in Aging through a TNFα/IGFBP-1/IGF1 Immune-Endocrine Axis

Researchers uncovered an immune-endocrine regulatory circuit that mediated cross-talk between peripheral B-cells and progenitors in the bone marrow, to balance B-lymphopoiesis in both human and mouse aging.
[Blood]
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A Reasoned Approach to the Treatment of Autoimmune Hepatitis

Autoimmune hepatitis is a chronic inflammatory liver disease affecting all ages, characterized by elevated transaminase and immunoglobulin G levels, positive autoantibodies, interface hepatitis on histology and good response to immunosuppressive treatment.
[Digestive and Liver Disease]
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Inflammatory Bowel Disease Induces Inflammatory and Pre-Neoplastic Changes in the Prostate

Scientists investigated whether chronic intestinal inflammation led to pro-inflammatory changes associated with tumorigenesis in the prostate.
[Prostate Cancer and Prostatic Diseases]
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Distribution Difference of Colostrum-Derived B and T Cells Subsets in Gilts and Sows

Investigators serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows from a commercial herd were examined.
[PLoS One]
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Single-Cell Multi-Omics Analysis of the Immune Response in COVID-19

Scientists highlight the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy.
[Nature Medicine]
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