Distribution Difference of Colostrum-Derived B and T Cells Subsets in Gilts and Sows

Investigators serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows from a commercial herd were examined.
[PLoS One]
Forner, R., Bombassaro, G., Bellaver, F. V., Maciag, S., Fonseca, F. N., Gava, D., Lopes, L., Marques, M. G., & Bastos, A. P. (2021). Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. PLOS ONE, 16(5), e0249366. https://doi.org/10.1371/journal.pone.0249366 Cite
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Single-Cell Multi-Omics Analysis of the Immune Response in COVID-19

Scientists highlight the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy.
[Nature Medicine]
Stephenson, E., Reynolds, G., Botting, R. A., Calero-Nieto, F. J., Morgan, M. D., Tuong, Z. K., Bach, K., Sungnak, W., Worlock, K. B., Yoshida, M., Kumasaka, N., Kania, K., Engelbert, J., Olabi, B., Spegarova, J. S., Wilson, N. K., Mende, N., Jardine, L., Gardner, L. C. S., … Haniffa, M. (2021). Single-cell multi-omics analysis of the immune response in COVID-19. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-021-01329-2 Cite
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Atlas of Breast Cancer Infiltrated B-Lymphocytes Revealed by Paired Single-Cell RNA-Sequencing and Antigen Receptor Profiling

Researchers combined single-cell RNA-sequencing and antigen receptor lineage analysis to characterize a large number of triple-negative breast cancer infiltrated immune cells and report a comprehensive atlas of tumor-infiltrated B-lymphocytes.
[Nature Communications]
Hu, Q., Hong, Y., Qi, P., Lu, G., Mai, X., Xu, S., He, X., Guo, Y., Gao, L., Jing, Z., Wang, J., Cai, T., & Zhang, Y. (2021). Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling. Nature Communications, 12(1), 2186. https://doi.org/10.1038/s41467-021-22300-2 Cite
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The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

The authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
[International Journal of Molecular Sciences]
Magatti, M., Masserdotti, A., Cargnoni, A., Papait, A., Stefani, F. R., Silini, A. R., & Parolini, O. (2021). The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy? International Journal of Molecular Sciences, 22(7), 3405. https://doi.org/10.3390/ijms22073405 Cite
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Adaptive Immunity at the Crossroads of Autophagy and Metabolism

The authors summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate, especially for T and B lymphocytes.
[Cellular & Molecular Immunology]
Metur, S. P., & Klionsky, D. J. (2021). Adaptive immunity at the crossroads of autophagy and metabolism. Cellular & Molecular Immunology, 1–10. https://doi.org/10.1038/s41423-021-00662-3 Cite
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Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System

Using patient-derived iPSCs and an in vitro artificial thymic organoid system as a model, investigators demonstrate that gene editing rescued the progressive T cell differentiation potential of RAG2-deficient cells to normal levels, with generation of a diversified T cell repertoire.
[Journal of Clinical Immunology]
Gardner, C. L., Pavel-Dinu, M., Dobbs, K., Bosticardo, M., Reardon, P. K., Lack, J., DeRavin, S. S., Le, K., Bello, E., Pala, F., Delmonte, O. M., Malech, H., Montel-Hagan, A., Crooks, G., Acuto, O., Porteus, M. H., & Notarangelo, L. D. (2021). Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System. Journal of Clinical Immunology. https://doi.org/10.1007/s10875-021-00989-6 Cite
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Pre-Mitotic Genome Re-Organisation Bookends the B Cell Differentiation Process

Scientists elucidated the chromosome conformational changes in B lymphocytes as they differentiated and expanded from a naive, quiescent state into antibody secreting plasma cells.
[Nature Communications]
Chan, W. F., Coughlan, H. D., Zhou, J. H. S., Keenan, C. R., Bediaga, N. G., Hodgkin, P. D., Smyth, G. K., Johanson, T. M., & Allan, R. S. (2021). Pre-mitotic genome re-organisation bookends the B cell differentiation process. Nature Communications, 12(1), 1344. https://doi.org/10.1038/s41467-021-21536-2 Cite
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CD20 as a Gatekeeper of the Resting State of Human B Cells

Researchers demonstrated that CD20 controlled the nanoscale organization of receptors on the surface of resting B lymphocytes.
[Proceedings of the National Academy of Sciences of the United States of America]
Kläsener, K., Jellusova, J., Andrieux, G., Salzer, U., Böhler, C., Steiner, S. N., Albinus, J. B., Cavallari, M., Süß, B., Voll, R. E., Boerries, M., Wollscheid, B., & Reth, M. (2021). CD20 as a gatekeeper of the resting state of human B cells. Proceedings of the National Academy of Sciences, 118(7). https://doi.org/10.1073/pnas.2021342118 Cite
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Signal-Transducing Adaptor Protein-2 Delays Recovery of B Lineage Lymphocytes during Hematopoietic Stress

The authors exploited gene targeted and transgenic mice, and demonstrated that signal-transducing adaptor protein-2 was not required under normal, steady-state conditions.
[Haematologica]
Ichii, M., Oritani, K., Toda, J., Saito, H., Shi, H., Shibayama, H., Motooka, D., Kitai, Y., Muromoto, R., Kashiwakura, J., Saitoh, K., Okuzaki, D., Matsuda, T., & Kanakura, Y. (2021). Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress. Haematologica, 106(2), 424–436. https://doi.org/10.3324/haematol.2019.225573 Cite
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The Influence of Tumor Microenvironment on Immune Escape of Melanoma

The authors provides a comprehensive summary of the processes regulated by tumor-associated cells that promote the immune escape of melanoma cells.
[International Journal of Molecular Sciences]
Simiczyjew, A., Dratkiewicz, E., Mazurkiewicz, J., Ziętek, M., Matkowski, R., & Nowak, D. (2020). The Influence of Tumor Microenvironment on Immune Escape of Melanoma. International Journal of Molecular Sciences, 21(21), 8359. https://doi.org/10.3390/ijms21218359 Cite
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Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection

Researchers examined immune cell subsets in hospitalized and non-hospitalized individuals. In hospitalized patients, many adaptive and innate immune cells were decreased in frequency compared to healthy and convalescent individuals, with the exception of B lymphocytes which increased
[Journal of Clinical Investigation]
Files, J. K., Boppana, S., Perez, M. D., Sarkar, S., Lowman, K. E., Qin, K., Sterrett, S., Carlin, E., Bansal, A., Sabbaj, S., Long, D. M., Kutsch, O., Kobie, J., Goepfert, P., & Erdmann, N. (2020). Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140491 Cite
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