B-lymphocytes

[Nature Reviews Cancer] Drawing insights from autoimmunity, scientists review the molecular phenotypes, architectural contexts, antigen specificities, effector mechanisms and regulatory pathways relevant to tumor-infiltrating B lymphocytes in human cancer.

[npj Parkinsons Disease] Using two chimeric mouse models, scientists demonstrated that the replacement of mutant LRRK2 with wild-type formed of the protein in T- and B-lymphocytes diminished LPS-mediated inflammation and rescued the substantia nigra pars compacta dopamine neuron loss in the mutant LRRK2 brain.

[Molecular Cancer Research] The authors showed that O-GlcNAcylation of B lymphocyte-induced maturation protein-1 (Blimp-1) in lymphocytes inhibited the migration and invasion of breast cancer cells. It was found that Blimp-1 O-GlcNAcylation at Ser448 and Ser472 in lymphocytes promoted its nuclear localization, and blocked the bindings to three regions upstream of the ccl3l1 promoter to inhibit its expression.

[Oncology and Therapy] Researchers hypothesized that progressive changes in gene expression resulted in malignant transformation of B lymphocytes to family histroy of monoclonal B lymphocytosis, and subsequent alterations in gene expression occur before overt family history of chronic lymphocytic leukemia develops.

[Nature] Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.

[Immunological Reviews] The authors focus on the role of miRNAs in the regulation of B cell receptor signaling as it pertains to B lymphocyte development and function.