B-lymphocytes

[PLOS Pathogens] Investigators identified a major EBNA2 binding site downstream of the CIITA gene and upstream of DEXI, a dexamethasone inducible gene that is oriented head-to-head with CIITA gene transcripts.

[Autophagy] Researchers mechanistically and functionally linked CD38 and LRRK2 as upstream activators of TFEB, a host defense transcription factor and the master transcriptional regulator of the autophagy/lysosome machinery.

[Science Immunology] Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.

[Blood] Researchers uncovered an immune-endocrine regulatory circuit that mediated cross-talk between peripheral B-cells and progenitors in the bone marrow, to balance B-lymphopoiesis in both human and mouse aging.

[Digestive and Liver Disease] Autoimmune hepatitis is a chronic inflammatory liver disease affecting all ages, characterized by elevated transaminase and immunoglobulin G levels, positive autoantibodies, interface hepatitis on histology and good response to immunosuppressive treatment.

[Prostate Cancer and Prostatic Diseases] Scientists investigated whether chronic intestinal inflammation led to pro-inflammatory changes associated with tumorigenesis in the prostate.