B-lymphocytes

[PLoS One] Investigators serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows from a commercial herd were examined.

[Nature Medicine] Scientists highlight the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy.

[Nature Communications] Researchers combined single-cell RNA-sequencing and antigen receptor lineage analysis to characterize a large number of triple-negative breast cancer infiltrated immune cells and report a comprehensive atlas of tumor-infiltrated B-lymphocytes.

[International Journal of Molecular Sciences] The authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.

[Cellular & Molecular Immunology] The authors summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate, especially for T and B lymphocytes.

[Journal of Clinical Immunology] Using patient-derived iPSCs and an in vitro artificial thymic organoid system as a model, investigators demonstrate that gene editing rescued the progressive T cell differentiation potential of RAG2-deficient cells to normal levels, with generation of a diversified T cell repertoire.