Bax

[Journal of Pharmacy and Pharmacology] With the help of cell cytotoxicity, the effect of tonkinensine B on MDA-MB-231 cells was investigated. The levels of key apoptosis-associated proteins Bcl-2, Bax, caspase-9, caspase-3 and AKT in MDA-MB-231 cells were analysed to determine whether tonkinensine B caused apoptosis via the mitochondrial pathway.

[Scientific Reports] Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.

[Laboratory Investigation] Scientists investigated the mechanism by which curcumin affected the resistance of acute myeloid leukemia to Adriamycin by regulating HOX transcript antisense RNA (HOTAIR) expression.

[Cell Death & Disease] Researchers investigated the involvement of zinc finger protein 36 (ZFP36) and cAMP‐response element-binding protein binding protein (CREBBP) on ischemia–reperfusion (I/R)-induced lung injury in vivo and in vitro.

[Journal of Molecular Endocrinology] Researchers investigated the mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) pathway in cultured cells and isolated mouse islets.

[Biomedical Materials] Researchers evaluated cell death in mammospheres from MCF-7 and primary tumor cells in response to curcumin loaded on graphene nanosheets. The nanocarriers graphene oxide and graphene quantum dots had no cytotoxic effect on Kerman male breast cancer/71 and MCF-7 tumor cells, while those loaded with curcumin induced death in more than 50% of tumor cells.