Bax

[Oxidative Medicine and Cellular Longevity] In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.

[Oncology Reports] The combined effect of Diosmin and naringenin in colon cancer cell lines HCT116 and SW480 were assessed by targeting apoptosis and inflammatory pathways.

[Heliyon] Scientists investigated the effect of insulin-producing cells derived from adipose tissue MSCs on diabetic-induced impairments as the abnormalities of testicular tissues, oxidative stress of testes, and defects of spermatogenesis.

[Scientific Reports] Investigators used peripheral blood and bone marrow samples from patients with acute myeloid leukemia (AML) to analyze the impact of CD157-directed antibodies in AML survival and in response to cytarabine ex vivo.

[Cell Death Discovery] The authors indicated that RCAN1.4 expression was impaired both in unilateral ureteral obstruction-induced renal fibrosis in vivo and TGF-β1-induced renal fibrosis in vitro. However, knocking in of RCAN1.4 suppressed the production of ECM both in vivo and in vitro.

[Metallomics] Researchers found that maternal selenium (Se) deficiency decreased placental Se concentration and expressions of some antioxidant selenoproteins.