Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines

The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics]
Ebrahimi, M., Babaei, E., Neri, F., & Feizi, M. A. H. (2021). Anti-proliferative and apoptotic effect of gemini curcumin in p53-wild type and p53-mutant colorectal cancer cell lines. International Journal of Pharmaceutics, 601, 120592. https://doi.org/10.1016/j.ijpharm.2021.120592 Cite
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β-Elemonic Acid Inhibits Growth and Triggers Apoptosis in Human Castration-Resistant Prostate Cancer Cells through the Suppression of JAK2/STAT3/MCL-1 and NF-ĸB Signal Pathways

The present research in vitro and in vivo systematically investigated anti-cancer effects and mechanisms of β-elemonic acid on human castration-resistant prostate cancer.
[Chemico-Biological Interactions]
Bao, X., Zhu, J., Ren, C., Zhao, A., Zhang, M., Zhu, Z., Lu, X., Zhang, Y., Li, X., Sima, X., Li, J., Zhang, Q., & Ma, B. (2021). β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways. Chemico-Biological Interactions, 109477. https://doi.org/10.1016/j.cbi.2021.109477 Cite
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FOXO3a Protects Glioma Cells against Temozolomide-Induced DNA Double Strand Breaks via Promotion of BNIP3-Mediated Mitophagy

Scientists investigated the role of forkhead box transcription factor 3a (FOXO3a) in regulating the sensitivity of glioma cells to temozolomide and its relationship with Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3)-mediated mitophagy.
[Acta Pharmacologica Sinica]
FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy | Acta Pharmacologica Sinica. (n.d.). Retrieved April 20, 2021, from https://www.nature.com/articles/s41401-021-00663-y Cite
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Lupeol Induces Autophagy and Apoptosis with Reduced Cancer Stem-Like Properties in Retinoblastoma via Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Inhibition

Lupeol could also inhibit proliferation and induce apoptosis of retinoblastoma cells, with increased Bax level and decreased Ki67, survivin and Bcl-2 levels.
[Journal of Pharmacy and Pharmacology]
Che, S., Wu, S., & Yu, P. (2021). Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma via phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin inhibition. Journal of Pharmacy and Pharmacology, rgab060. https://doi.org/10.1093/jpp/rgab060 Cite
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Combining Radiation to EGFR and Bcl-2 Blockade: A New Approach to Target Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

CSCs had low EGFR expression and, conversely, overexpressed the anti-apoptotic Bcl-2 protein, which is involved in resistance to apoptosis and the invasion/migration capacities of tumor cells.
[Journal of Cancer Research and Clinical Oncology]
Guy, J.-B., Espenel, S., Louati, S., Gauthier, A., Garcia, M.-A., Vial, N., Malésys, C., Ardail, D., Alphonse, G., Wozny, A.-S., Rodriguez-Lafrasse, C., & Magné, N. (2021). Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-021-03593-8 Cite
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Targeting AXL Kinase Sensitizes Leukemic Stem and Progenitor Cells to Venetoclax Treatment in Acute Myeloid Leukemia

Researchers demonstrated that a key GAS6/AXL axis was highly activated in acute myeloid leukemia patient cells, particularly in stem/progenitor cells.
[Blood]
Niu, X., Rothe, K., Chen, M., Grasedieck, S., Li, R., Nam, S.-E., Zhang, X., Novakovskiy, G., Ahn, Y.-H., Maksakova, I. A., Lai, S., Zhang, H., Yan, J., Liu, H., Zhao, Y., Wu, D., Ge, Y., Wasserman, W., Rouhi, A., … Jiang, X. (2021). Targeting AXL Kinase Sensitizes Leukemic Stem and Progenitor Cells to Venetoclax Treatment in Acute Myeloid Leukemia. Blood, blood.2020007651. https://doi.org/10.1182/blood.2020007651 Cite
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Protection of β-Pancreatic Cells From Dysfunctionality of Insulin Using Vitexin by Apoptosis of INS-1 Cells

The authors explored the possible beneficial effects of vitexin on high glucose-induced cytotoxicity in pancreatic β-cells. The INS-1 pancreatic β-cell line was used in this study.
[Archives of Physiology and Biochemistry]
Zhang, L., Shi, L., Han, J., & Li, Z. (2021). Protection of β-pancreatic cells from dysfunctionality of insulin using vitexin by apoptosis of INS-1 cells. Archives of Physiology and Biochemistry, 0(0), 1–8. https://doi.org/10.1080/13813455.2021.1910714 Cite
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Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro

Guava seed polysaccharides (GSPS), GSF1, GSF2, and GSF3 were isolated using Sepharose 6B gel filtration chromatography to assay their inhibitory effects on prostate PC-3 cell growth with direct action or indirect immunotherapy.
[International Journal of Molecular Sciences]
Lin, H.-C., & Lin, J.-Y. (2021). Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro. International Journal of Molecular Sciences, 22(7), 3631. https://doi.org/10.3390/ijms22073631 Cite
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Breast Cancer Dependence on MCL-1 Is Due to Its Canonical Anti-apoptotic Function

Scientists investigated the role of MCL-1 in clinically relevant breast cancer models and address whether the canonical role of MCL-1 in apoptosis, which can be targeted using BH3-mimetic drugs, is the major function for MCL-1 in breast cancer.
[Cell Death & Differentiation]
Campbell, K. J., Mason, S. M., Winder, M. L., Willemsen, R. B. E., Cloix, C., Lawson, H., Rooney, N., Dhayade, S., Sims, A. H., Blyth, K., & Tait, S. W. G. (2021). Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death & Differentiation, 1–12. https://doi.org/10.1038/s41418-021-00773-4 Cite
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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Neuromodulation of BAG Co-Chaperones by HIV-1 Viral Proteins and H2O2: Implications for HIV-Associated Neurological Disorders

Present results revealed 2O2 replicated and exacerbated a reduction in neuronal BCL-2 associated athanogene 3 (BAG3) induced by the expression of HIV-1 viral proteins, while also causing an upregulation of BAG1.
[Cell Death Discovery]
Duggan, M. R., Mohseni Ahooyi, T., Parikh, V., & Khalili, K. (2021). Neuromodulation of BAG co-chaperones by HIV-1 viral proteins and H 2 O 2 : implications for HIV-associated neurological disorders. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-021-00424-0 Cite
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