The toxicity of Gemini-Cur on HT-29 and HCT116 was studied through MTT, uptake kinetics, fluorescence microscopy, annexin V/FITC, and cell cycle assays.
[International Journal of Pharmaceutics]
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The present research in vitro and in vivo systematically investigated anti-cancer effects and mechanisms of β-elemonic acid on human castration-resistant prostate cancer.
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Bao, X., Zhu, J., Ren, C., Zhao, A., Zhang, M., Zhu, Z., Lu, X., Zhang, Y., Li, X., Sima, X., Li, J., Zhang, Q., & Ma, B. (2021). β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways. Chemico-Biological Interactions, 109477. https://doi.org/10.1016/j.cbi.2021.109477 Cite
Scientists investigated the role of forkhead box transcription factor 3a (FOXO3a) in regulating the sensitivity of glioma cells to temozolomide and its relationship with Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3)-mediated mitophagy.
[Acta Pharmacologica Sinica]
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FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy | Acta Pharmacologica Sinica. (n.d.). Retrieved April 20, 2021, from https://www.nature.com/articles/s41401-021-00663-y Cite
Lupeol could also inhibit proliferation and induce apoptosis of retinoblastoma cells, with increased Bax level and decreased Ki67, survivin and Bcl-2 levels.
[Journal of Pharmacy and Pharmacology]
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Che, S., Wu, S., & Yu, P. (2021). Lupeol induces autophagy and apoptosis with reduced cancer stem-like properties in retinoblastoma via phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin inhibition. Journal of Pharmacy and Pharmacology, rgab060. https://doi.org/10.1093/jpp/rgab060 Cite
CSCs had low EGFR expression and, conversely, overexpressed the anti-apoptotic Bcl-2 protein, which is involved in resistance to apoptosis and the invasion/migration capacities of tumor cells.
[Journal of Cancer Research and Clinical Oncology]
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Guy, J.-B., Espenel, S., Louati, S., Gauthier, A., Garcia, M.-A., Vial, N., Malésys, C., Ardail, D., Alphonse, G., Wozny, A.-S., Rodriguez-Lafrasse, C., & Magné, N. (2021). Combining radiation to EGFR and Bcl-2 blockade: a new approach to target cancer stem cells in head and neck squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-021-03593-8 Cite
Researchers demonstrated that a key GAS6/AXL axis was highly activated in acute myeloid leukemia patient cells, particularly in stem/progenitor cells.
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Niu, X., Rothe, K., Chen, M., Grasedieck, S., Li, R., Nam, S.-E., Zhang, X., Novakovskiy, G., Ahn, Y.-H., Maksakova, I. A., Lai, S., Zhang, H., Yan, J., Liu, H., Zhao, Y., Wu, D., Ge, Y., Wasserman, W., Rouhi, A., … Jiang, X. (2021). Targeting AXL Kinase Sensitizes Leukemic Stem and Progenitor Cells to Venetoclax Treatment in Acute Myeloid Leukemia. Blood, blood.2020007651. https://doi.org/10.1182/blood.2020007651 Cite
The authors explored the possible beneficial effects of vitexin on high glucose-induced cytotoxicity in pancreatic β-cells. The INS-1 pancreatic β-cell line was used in this study.
[Archives of Physiology and Biochemistry]
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Guava seed polysaccharides (GSPS), GSF1, GSF2, and GSF3 were isolated using Sepharose 6B gel filtration chromatography to assay their inhibitory effects on prostate PC-3 cell growth with direct action or indirect immunotherapy.
[International Journal of Molecular Sciences]
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Scientists investigated the role of MCL-1 in clinically relevant breast cancer models and address whether the canonical role of MCL-1 in apoptosis, which can be targeted using BH3-mimetic drugs, is the major function for MCL-1 in breast cancer.
[Cell Death & Differentiation]
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Campbell, K. J., Mason, S. M., Winder, M. L., Willemsen, R. B. E., Cloix, C., Lawson, H., Rooney, N., Dhayade, S., Sims, A. H., Blyth, K., & Tait, S. W. G. (2021). Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death & Differentiation, 1–12. https://doi.org/10.1038/s41418-021-00773-4 Cite
ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
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Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
Present results revealed 2O2 replicated and exacerbated a reduction in neuronal BCL-2 associated athanogene 3 (BAG3) induced by the expression of HIV-1 viral proteins, while also causing an upregulation of BAG1.
[Cell Death Discovery]
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