Tag Archives: Bcl-2

EGFR/FOXO3a/BIM Signaling Pathway Determines Chemosensitivity of BMP4-Differentiated Glioma Stem Cells to Temozolomide

Scientists examined whether epidermal growth factor receptor (EGFR) signaling affects bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]
Ciechomska, I. A., Gielniewski, B., Wojtas, B., Kaminska, B., & Mieczkowski, J. (2020). EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-0479-9 Cite
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Rosmarinic Acid-Induced Apoptosis and Cell Cycle Arrest in Triple-Negative Breast Cancer Cells

Researchers evaluated the effects and mechanisms of rosmarinic acid (RA) in two racially different TNBC cell lines. Results obtained showed that RA significantly caused cytotoxic and antiproliferative effects in both cell lines in a dose- and time-dependent manner. RA induced cell cycle arrest-related apoptosis and altered the expression of many apoptosis-involved genes differently.
[European Journal of Pharmacology]
Messeha, S. S., Zarmouh, N. O., Asiri, A., & Soliman, K. F. A. (2020). Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. European Journal of Pharmacology, 173419. https://doi.org/10.1016/j.ejphar.2020.173419 Cite
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Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

The nanocomplexes formed by metallodendrimers and different siRNA were examined for their zeta potential and size, and by transmission electron microscopy, fluorescence polarisation, circular dichroism, and electrophoresis. The internalisation of dendriplexes was estimated by flow cytometry and confocal microscopy in a human breast cancer cell line, following the ability of these metallodendrimers to deliver the siRNA into the cell. In vitro cell viability experiments have indicated effective interactions between Cu (II) dendrimers and pro-apoptotic siRNAs: Mcl-1 and Bcl-2 in breast cancer cells.
[Pharmaceutics]
Sanz del Olmo, N., Holota, M., Michlewska, S., Gómez, R., Ortega, P., Ionov, M., de la Mata, F. J., & Bryszewska, M. (2020). Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells. Pharmaceutics, 12(8), 727. https://doi.org/10.3390/pharmaceutics12080727 Cite
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Regulatory T Cells Are Less Sensitive to Glucocorticoid Hormone Induced Apoptosis than CD4+ T Cells

Investigators analyzed the apoptosis-inducing effect of high dose in vitro dexamethasone treatment in mouse thymic- and splenic Tregs and CD4+ T cells.
[Apoptosis]
Prenek, L., Litvai, T., Balázs, N., Kugyelka, R., Boldizsár, F., Najbauer, J., Németh, P., & Berki, T. (2020). Regulatory T cells are less sensitive to glucocorticoid hormone induced apoptosis than CD4+ T cells. Apoptosis. https://doi.org/10.1007/s10495-020-01629-x Cite
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Probucol Enhances the Therapeutic Efficiency of Mesenchymal Stem Cells in the Treatment of Erectile Dysfunction in Diabetic Rats by Prolonging their Survival Time via Nrf2 Pathway

The authors investigated therapeutic efficiency and potential mechanism of probucol combined with mesenchymal stem cells.
[Stem Cell Research & Therapy]
Wang, H., Zhang, K., Ruan, Z., Sun, D., Zhang, H., Lin, G., Hu, L., Zhao, S., & Fu, Q. (2020). Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway. Stem Cell Research & Therapy, 11(1), 302. https://doi.org/10.1186/s13287-020-01788-3 Cite
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Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL-2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics

Researchers report that PRMT1 expression is increased in pancreatic cancer tissues and associated with higher tumor grade, increased aggressiveness and worse prognosis.
[Cancer Research]
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Antimalarial Agent Artesunate Induces G0/G1 Cell Cycle Arrest and Apoptosis via Increasing Intracellular ROS Levels in Normal Liver Cells

Researchers investigated the possible cytotoxic effects using normal BRL-3A and AML12 liver cells.
[Human & Experimental Toxicology]
Abstract

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PRKCQ Inhibition Enhances Chemosensitivity of Triple-negative Breast Cancer by Regulating Bim

Scientists showed that Protein kinase C theta regulated the sensitivity of TNBC cells to apoptosis triggered by standard-of-care chemotherapy by regulating levels of pro-apoptotic Bim.
[Breast Cancer Research]
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The Transcription Factor Hhex Cooperates with the Corepressor Tle3 to Promote Memory B Cell Development

Using single-cell RNA sequencing analysis, the authors identified a population of germinal center B cells in the process of differentiating into memory B cells.
[Nature Immunology]
Laidlaw, B. J., Duan, L., Xu, Y., Vazquez, S. E., & Cyster, J. G. (2020). The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0713-6 Cite
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