Using tumor expression data and non-negative matrix factorization, scientists identified four small cell lung cancer (SCLC) subtypes defined largely by differential expression of transcription factors ASCL1, NEUROD1, and POU2F3 or low expression of all three transcription factor signatures accompanied by an Inflamed gene signature.
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Gay, C. M., Stewart, C. A., Park, E. M., Diao, L., Groves, S. M., Heeke, S., Nabet, B. Y., Fujimoto, J., Solis, L. M., Lu, W., Xi, Y., Cardnell, R. J., Wang, Q., Fabbri, G., Cargill, K. R., Vokes, N. I., Ramkumar, K., Zhang, B., Corte, C. M. D., … Byers, L. A. (2021). Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2020.12.014 Cite
The authors explored whether enhancer of zeste homolog 2-mediated paired box 8 methylation affects gastrointestinal stromal tumor (GIST) development through regulation of Wnt4. A total of 50 cases of GIST tissues were collected and the human GIST cell lines were cultured.
[Cancer Gene Therapy]
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Using liver-specific G9a-deficient mice, scientists revealed that loss of G9a significantly attenuated liver tumor initiation caused by diethylnitrosamine.
[Cell Death & Disease]
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Nakatsuka, T., Tateishi, K., Kato, H., Fujiwara, H., Yamamoto, K., Kudo, Y., Nakagawa, H., Tanaka, Y., Ijichi, H., Ikenoue, T., Ishizawa, T., Hasegawa, K., Tachibana, M., Shinkai, Y., & Koike, K. (2021). Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis. Cell Death & Disease, 12(1), 1–13. https://doi.org/10.1038/s41419-020-03381-1 Cite
Hepatic stellate cell (HSC)‐T6 cells were activated by interleukin-1 beta and then treated with helenalin. HSC‐T6 cells were transfected with miR-200a mimic or inhibitor, and the effect of helenalin on the miR-200a-mediated PI3K/Akt and NF-κB signaling pathways was investigated.
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Fang, B., Wen, S., Li, Y., Bai, F., Wei, Y., Xiong, Y., Huang, Q., & Lin, X. (2021). Prediction and verification of target of helenalin against hepatic stellate cell activation based on miR-200a-mediated PI3K/Akt and NF-κB pathways. International Immunopharmacology, 92, 107208. https://doi.org/10.1016/j.intimp.2020.107208 Cite
Scientists found that the antiandrogen Enzalutamide-resistant prostate cancer cells can be suppressed by hyper-physiological doses of the androgen DHT.
[Cell Death & Disease]
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Xiang, Z., Sun, Y., You, B., Zhang, M., Huang, C., Yu, J., You, X., Wu, D., & Chang, C. (2021). Suppressing BCL-XL increased the high dose androgens therapeutic effect to better induce the Enzalutamide-resistant prostate cancer autophagic cell death. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03321-z Cite
Researchers showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which play crucial roles in lung cancer.
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Researchers investigated the in vitro role of microRNA-520d-3p in human myocardial cell myocardial H/R injury.
[Journal of Thrombosis and Thrombolysis]
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Using cells derived from surgically resected tissue, investigators demonstrated that young pediatric-aged sample oligodendrocytes (OLs) were more resistant to in-vitro metabolic injury than fetal O4+ progenitor cells, but more susceptible to cell death and apoptosis than adult-derived OLs.
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Fernandes, M. G. F., Luo, J. X. X., Cui, Q.-L., Perlman, K., Pernin, F., Yaqubi, M., Hall, J. A., Dudley, R., Srour, M., Couturier, C. P., Petrecca, K., Larochelle, C., Healy, L. M., Stratton, J. A., Kennedy, T. E., & Antel, J. P. (2021). Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways. Communications Biology, 4(1), 1–10. https://doi.org/10.1038/s42003-020-01557-1 Cite
Scientists showed that albanol B inhibited the proliferation of four human lung cancer cell lines and induced apoptosis, based on the cleavage of caspase-7 and PARP, as well as the downregulation of Bcl-2.
[International Journal of Molecular Sciences]
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The anti-cancer mechanism of Isoquercitrin (IQ) against human melanoma, particularly its effect on the mitochondria-mediated apoptosis, was investigated. Treatment with IQ at 25 μM concentration effectively inhibited the proliferation of SK-MEL-2 skin cancer cells while the same concentration did not exhibit cytotoxicity against human keratinocytes HaCaT.
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Researchers investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib, a recently FDA-approved BRAFV600E inhibitor.