Identification of BCL-XL as Highly Active Survival Factor and Promising Therapeutic Target in Colorectal Cancer

By RNA sequencing analysis of a pan-cancer cohort comprising >1500 patients and subsequent prediction of protein activity, BCL-XL was identified as the only antiapoptotic BCL-2 protein that was overactivated in colorectal cancer.
[Cell Death & Disease]
Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer | Cell Death & Disease. (n.d.). Retrieved October 19, 2020, from https://www.nature.com/articles/s41419-020-03092-7# Cite
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Shrimp Shells Extracted Chitin in Silver Nanoparticle Synthesis: Expanding Its Prophecy towards Anticancer Activity in Human Hepatocellular Carcinoma HepG2 Cells

The well-organized, simplistic, and biological route of AgNPs (AgNPs) was synthesized using shrimp shell extracted chitin as reducing, capping and stabilizing factor under the optimized conditions. The anticancer potential of synthesized biogenic AgNPs was evaluated against human hepatocarcinoma cells.
[International Journal of Biological Macromolecules]
Vijayakumar, M., Priya, K., Ilavenil, S., Janani, B., Vedarethinam, V., Ramesh, T., Arasu, M. V., Al-Dhabi, N. A., Kim, Y.-O., & Kim, H.-J. (2020). Shrimp shells extracted chitin in silver nanoparticle synthesis: Expanding its prophecy towards anticancer activity in human hepatocellular carcinoma HepG2 cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.10.032 Cite
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Pancreas-Specific Deletion of Protein Kinase D Attenuates Inflammation, Necrosis, and Severity of Acute Pancreatitis

Investigators generated a mouse model with pancreas-specific deletion of PKD3, the predominant PKD isoform in mouse pancreatic acinar cells, by crossing Pkd3flox/flox mice with Pdx1-Cre transgenic mice which express Cre recombinase under the control of the mouse Pdx1 promoter.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease]
Yuan, J., Chheda, C., Piplani, H., Geng, M., Tan, G., Thakur, R., & Pandol, S. J. (2020). Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 165987. https://doi.org/10.1016/j.bbadis.2020.165987 Cite
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The Therapeutic Effect of the BRD4-Degrading PROTAC A1874 in Human Colon Cancer Cells

A1874-induced degradation of BRD4 protein and downregulated BRD-dependent genes in colon cancer cells. A1874-induced anti-colon cancer cell activity was more potent than the known BRD4 inhibitors. In BRD4-knockout colon cancer cells A1874 remained cytotoxic, indicating the existence of BRD4-independent mechanisms.
[Cell Death & Disease]
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Overexpressed sFRP3 Exerts an Inhibitory Effect on Hepatocellular Carcinoma via Inactivation of the Wnt/β-Catenin Signaling Pathway

Researchers investigated the possible regulatory effects of a secreted frizzled-related protein (sFRP3) on the Wnt/β-catenin signaling pathway and their interactions in hepatocellular carcinoma occurrence.
[Cancer Gene Therapy]
Fang, L., Gao, C., Bai, R.-X., Wang, H.-F., & Du, S.-Y. (2020). Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathway. Cancer Gene Therapy, 1–17. https://doi.org/10.1038/s41417-020-0201-z Cite
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Modeling the Function of BAX and BAK in Early Human Brain Development Using iPSC-Derived Systems

Scientists generated BAX/BAK double knockout human-induced pluripotent stem cells (hiPSCs), hiPSC-derived neural progenitor cells, neural rosettes, and cerebral organoids to uncover the effects of BAX and BAK deletion in an in vitro model of early human brain development.
[Cell Death & Disease]
Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems | Cell Death & Disease. (n.d.). Retrieved September 25, 2020, from https://www.nature.com/articles/s41419-020-03002-x Cite
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Preclinical Evaluation of a Regimen Combining Chidamide and ABT-199 in Acute Myeloid Leukemia

Scientists reported that a newly emerged histone deacetylase inhibitor, chidamide, at low-cytotoxicity dose enhanced the anti-AML activity of ABT-199, while sparing normal hematopoietic progenitor cells.
[Cell Death & Disease]
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Ascentage Pharma’s BC-2 Inhibitor APG-2575 Granted Orphan Drug Designation by the FDA for the Treatment of Chronic Lymphocytic Leukemia

Ascentage Pharma announced that the FDA has granted APG-2575, an Orphan Drug Designation for the treatment of chronic lymphocytic leukemia.
[Ascentage Pharma (PRNewswire,LLC)]
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Artesunate, as a HSP70 ATPase Activity Inhibitor, Induces Apoptosis in Breast Cancer Cells

Scientists evaluated the inhibitory effects of artesunate on HSP70 and Bcl-2 expression in two breast cancer cell lines, 4T1 and MCF-7.
[International Journal of Biological Macromolecules]
Pirali, M., Taheri, M., Zarei, S., Majidi, M., & Ghafouri, H. (2020). Artesunate, as a HSP70 ATPase activity inhibitor, induces apoptosis in breast cancer cells. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.08.198 Cite
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Molecular Evidence of IGFBP-3 Dependent and Independent VD3 Action and Its Nonlinear Response on IGFBP-3 Induction in Prostate Cancer Cells

Changes in IGFBP-3 expression levels in LNCaP cells indicated that it mediated the inhibition of cell growth induced by VD3 treatment. IGFBP-3 was also found to be a mediator of the enhanced cytotoxicity of prostate cancer cells to VD3 in combination with the anti-cancer drug.
[BMC Cancer]
Igarashi, K., Yui, Y., Watanabe, K., Kumai, J., Nishizawa, Y., Miyaura, C., Inada, M., & Sasagawa, S. (2020). Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells. BMC Cancer, 20(1), 802. https://doi.org/10.1186/s12885-020-07310-5 Cite
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A Newly Isolated Strain of Halomonas sp. (HA1) Exerts Anticancer Potential via Induction of Apoptosis and G2/M Arrest in Hepatocellular Carcinoma (HepG2) Cell Line

Researchers suggested that the apoptotic and anti-proliferative effects of Halomonas sp. HA1 extracted on HepG2 cells can provide it as a candidate for future pharmaceutical industries.
[Scientific Reports]
El-Garawani, I. M., El-Sabbagh, S. M., Abbas, N. H., Ahmed, H. S., Eissa, O. A., Abo-Atya, D. M., Khalifa, S. A. M., & El-Seedi, H. R. (2020). A newly isolated strain of Halomonas sp. (HA1) exerts anticancer potential via induction of apoptosis and G 2 /M arrest in hepatocellular carcinoma (HepG2) cell line. Scientific Reports, 10(1), 14076. https://doi.org/10.1038/s41598-020-70945-8 Cite
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