Bcl-2

[Acta Pharmacologica Sinica] The authors identified a natural product patchouli alcohol as a selective estrogen receptor β agonist which improved the cognitive defects in female APP/PS1 mice, and explored the underlying mechanisms.

[Molecular Biology Reports] H. leucospilota was collected, the methanolic extract was prepared and in vitro cytotoxicity of H. leucospilota extract in the range of 12.5, 25, 50, 100, and 200 μg/mL concentrations for 48 hours on SK-BR-3 and MCR5 cells was determined.

[Advances in Experimental Medicine and Biology] Researchers measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies and sera of nonischemic PVB19-positive and PVB19-negative dilated cardiomyopathy patients.

[Leukemia] When analyzing the effects of BH3-mimetics selectively targeting BCL-XL and MCL-1 alone or in combination with the BCL-2 inhibitor venetoclax, heterogeneous sensitivity to either of these inhibitors was found in ALL cell lines and in patient-derived xenografts.

[Journal of Enzyme inhibition and Medicinal Chemistry] The potential synergistic anticancer effect and the underlying mechanisms of roburic acid in combination with docetaxel on prostate cancer were investigated.

[Brain Research Bulletin] Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.