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Bcl-2

Dapagliflozin Attenuates Pressure Overload-Induced Myocardial Remodeling in Mice via Activating SIRT1 and Inhibiting Endoplasmic Reticulum Stress

[Acta Pharmacologica Sinica] In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.

Phase Ib Study of the BET Protein Inhibitor RO6870810 with Venetoclax and Rituximab in Patients with Diffuse Large B Cell Lymphoma

[Blood Advances] Researchers reported results of a phase Ib dose-escalation study of the novel, subcutaneous BET inhibitor RO6870810 combined with the BCL-2 inhibitor venetoclax, and rituximab, in recurrent/refractory diffuse large B cell lymphoma.

Inhibition of the Bromodomain and Extra-Terminal Family of Epigenetic Regulators as a Promising Therapeutic Approach for Gastric Cancer

[Cellular Oncology] The effect of BET inhibition was evaluated using iBET-151, a small-molecule inhibitor of BET proteins, in a large panel of gastric cancer cell lines and xenograft mouse models. The synergistic effect of iBET-151 and paclitaxel was evaluated using an organoid model.

Vascular Endothelial Growth Factor Ameliorated Palmitate-Induced Cardiomyocyte Injury via JNK Pathway

[Animal] To investigate the preservative effects of vascular endothelial growth factor sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model.

Idarubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes: An In Vitro Molecular Approach

[Human & Experimental Toxicology] Scientists investigated the effects of Idarubicin (IDA) on the HL-1 cardiac muscle cell. Different concentrations of IDA were used at different time periods, and the Cell Counting Kit-8; 2,7-dichlorodihydrofluorescein diacetate probe method; and ELISA were used to detect the oxidative stress level.

Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation

[Oxidative Medicine and Cellular Longevity] In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.

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