Tag results:
Bcl-2
Intestinal Cell News
Dapagliflozin Attenuates Pressure Overload-Induced Myocardial Remodeling in Mice via Activating SIRT1 and Inhibiting Endoplasmic Reticulum Stress
[Acta Pharmacologica Sinica] In vitro, scientists found that DAPA inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II (Ang II)-treated cardiomyocytes.
Hematopoiesis News
Phase Ib Study of the BET Protein Inhibitor RO6870810 with Venetoclax and Rituximab in Patients with Diffuse Large B Cell Lymphoma
[Blood Advances] Researchers reported results of a phase Ib dose-escalation study of the novel, subcutaneous BET inhibitor RO6870810 combined with the BCL-2 inhibitor venetoclax, and rituximab, in recurrent/refractory diffuse large B cell lymphoma.
Organoid News
Inhibition of the Bromodomain and Extra-Terminal Family of Epigenetic Regulators as a Promising Therapeutic Approach for Gastric Cancer
[Cellular Oncology] The effect of BET inhibition was evaluated using iBET-151, a small-molecule inhibitor of BET proteins, in a large panel of gastric cancer cell lines and xenograft mouse models. The synergistic effect of iBET-151 and paclitaxel was evaluated using an organoid model.
Intestinal Cell News
Vascular Endothelial Growth Factor Ameliorated Palmitate-Induced Cardiomyocyte Injury via JNK Pathway
[Animal] To investigate the preservative effects of vascular endothelial growth factor sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model.
Intestinal Cell News
Idarubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes: An In Vitro Molecular Approach
[Human & Experimental Toxicology] Scientists investigated the effects of Idarubicin (IDA) on the HL-1 cardiac muscle cell. Different concentrations of IDA were used at different time periods, and the Cell Counting Kit-8; 2,7-dichlorodihydrofluorescein diacetate probe method; and ELISA were used to detect the oxidative stress level.
Cancer Stem Cell News
Inhibition of Vascular Smooth Muscle and Cancer Cell Proliferation by New VEGFR Inhibitors and Their Immunomodulator Effect: Design, Synthesis, and Biological Evaluation
[Oxidative Medicine and Cellular Longevity] In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.