Convalescent Plasma Therapy for B-Cell Depleted Patients with Protracted COVID-19 Disease

Scientists report a series of 17 consecutive patients with profound B-cell lymphopenia and prolonged COVID-19 symptoms, negative IgG-IgM SARS-CoV-2 serology and a positive RNAemia measured by digital PCR who were treated with four units of COVID-19 convalescent plasma.
[Blood]
Hueso, T., Pouderoux, C., Péré, H., Beaumont, A.-L., Raillon, L.-A., Ader, F., Chatenoud, L., Eshagh, D., Szwebel, T.-A., Martinot, M., Camou, F., Crickx, E., Michel, M., Mahevas, M., Boutboul, D., Azoulay, E., Joseph, A., Hermine, O., Rouzaud, C., … Lacombe, K. (n.d.). Convalescent plasma therapy for B-cell depleted patients with protracted COVID-19 disease. Blood. https://doi.org/10.1182/blood.2020008423 Cite
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Prognostic Value of Tertiary Lymphoid Structure and Tumor Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Associated markers of tertiary lymphoid structures (TLS), including peripheral node address in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 oral squamous cell carcinoma patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts.
[International Journal of Oral Science]
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Mitigating the Risk of Cytokine Release Syndrome in a Phase I Trial of CD20/CD3 Bispecific Antibody Mosunetuzumab in NHL: Impact of Translational System Modeling

The authors developed a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics, including the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumor.
[npj Systems Biology and Applications]
Hosseini, I., Gadkar, K., Stefanich, E., Li, C.-C., Sun, L. L., Chu, Y.-W., & Ramanujan, S. (2020). Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling. Npj Systems Biology and Applications, 6(1), 1–11. https://doi.org/10.1038/s41540-020-00145-7 Cite
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Vascular Remodeling and Immune Cell Infiltration in Splenic Artery Aneurysms

Analysis of splenic artery aneurysms revealed the presence of atherosclerotic lesions, calcifications, and intraluminal thrombus. Splenic artery aneurysms were characterized by a profound vascular remodeling with a dramatic loss of vascular smooth muscle cells, elastin degradation, adventitial fibrosis associated with enhanced apoptosis, and increased matrix metalloproteinase 9 expression.
[Angiology]
Clément, M., Lareyre, F., Loste, A., Sannier, A., Burel-Vandenbos, F., Massiot, N., Carboni, J., Jean-Baptiste, E., Caligiuri, G., Nicoletti, A., & Raffort, J. (2020). Vascular Remodeling and Immune Cell Infiltration in Splenic Artery Aneurysms: Angiology. https://doi.org/10.1177/0003319720952290 Cite
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TG Therapeutics Announces FDA Acceptance of New Drug Application for Umbralisib as a Treatment for Patients with Previously Treated Marginal Zone Lymphoma and Follicular Lymphoma

TG Therapeutics, Inc. announced that the FDA has accepted the company’s New Drug Application for umbralisib, the company’s investigational once-daily, oral, dual inhibitor of PI3K-delta and CK1-epsilon, as a treatment for patients with previously treated marginal zone lymphoma who have received at least one prior anti-CD20 based regimen and follicular lymphoma who have received at least two prior systemic therapies.
[TG Therapeutics, Inc.]
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Inhibition of Bruton’s Tyrosine Kinase Interferes with Pathogenic B-Cell Development in Inflammatory CNS Demyelinating Disease

Using mouse models of multiple scelrosis, investigators determined that evobrutinib, the first Burton’s tyrosine kinase inhibiting molecule being developed, dose-dependently inhibited antigen-triggered activation and maturation of B cells as well as their release of pro-inflammatory cytokines.
[Acta Neuropathologica]
Torke, S., Pretzsch, R., Häusler, D., Haselmayer, P., Grenningloh, R., Boschert, U., Brück, W., & Weber, M. S. (2020). Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease. Acta Neuropathologica. https://doi.org/10.1007/s00401-020-02204-z Cite
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Immune Status Is Prognostic for Poor Survival in Colorectal Cancer Patients and Is Associated with Tumor Hypoxia

Overall survival by immune and immune-checkpoint biomarkers in independent colorectal cancer cohorts was evaluated. Matched mutational and transcriptomic data were interrogated to identify associated biology.
[British Journal of Cancer]
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