A Novel Strategy for Isolation of Mice Bone Marrow Endothelial Cells (BMECs)

Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy]
Smith, A. O., Adzraku, S. Y., Ju, W., Qiao, J., Xu, K., & Zeng, L. (2021). A novel strategy for isolation of mice bone marrow endothelial cells (BMECs). Stem Cell Research & Therapy, 12(1), 267. https://doi.org/10.1186/s13287-021-02352-3 Cite
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Umbilical Cord-Derived MSC and Hyperbaric Oxygen Therapy Effectively Protected the Brain in Rat after Acute Intracerebral Haemorrhage

Scientists tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells and hyperbaric oxygen was superior to either one on preserving neurological function and reducing brain haemorrhagic volume in rat after acute intracerebral haemorrhage induced by intracranial injection of collagenase.
[Journal of Cellular and Molecular Medicine]
Yip, H.-K., Lin, K.-C., Sung, P.-H., Chiang, J. Y., Yin, T.-C., Wu, R.-W., & Chen, K.-H. (n.d.). Umbilical cord-derived MSC and hyperbaric oxygen therapy effectively protected the brain in rat after acute intracerebral haemorrhage. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16577 Cite
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Rapid Endotheliitis and Vascular Damage Characterize SARS-CoV-2 Infection in a Human Lung-Chip Model

Using a vascularised lung‐on‐chip model, scientists found that infection of alveolar epithelial cells leads to limited apical release of virions, consistent with reports of monoculture infection.
[EMBO Reports]
Thacker, V. V., Sharma, K., Dhar, N., Mancini, G.-F., Sordet-Dessimoz, J., & McKinney, J. D. (2021). Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-chip model. EMBO Reports, n/a(n/a), e52744. https://doi.org/10.15252/embr.202152744 Cite
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Increased Angiogenesis and Migration of Dermal Microvascular Endothelial Cells from Patients with Psoriasis

Researchers isolated human dermal microvascular endothelial cells (HDMECs) from the skin of ten patients with psoriasis and ten healthy subjects and compared angiogenesis, proliferation, migration and cell metabolism between psoriatic HDMECs and normal HDMECs.
[Experimental Dermatology]
Li, J., Hou, H., Zhou, L., Wang, J., Liang, J., Li, J., Hou, R., Niu, X., Yin, G., Li, X., & Zhang, K. (n.d.). Increased angiogenesis and migration of dermal microvascular endothelial cells from patients with psoriasis. Experimental Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/exd.14329 Cite
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Adipose-Derived Stromal/Stem Cell Culture: Effects of Different Concentrations of Human Platelet Lysate in Media

Scientists investigated the effect of 5, 10, or 20% pHPL in culture media on adipose-derived stromal/stem cell proliferation and phenotypic marker expression.
[Cells Tissues Organs]
Ballesteros, O. R., Brooks, P. T., Haastrup, E. K., Fischer-Nielsen, A., Munthe-Fog, L., & Svalgaard, J. D. (2021). Adipose-Derived Stromal/Stem Cell Culture: Effects of Different Concentrations of Human Platelet Lysate in Media. Cells Tissues Organs, 1–9. https://doi.org/10.1159/000513604 Cite
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Effects of Diet, BMP-2 Treatment, and Femoral Skeletal Injury on Endothelial Cells Derived from the Ipsilateral and Contralateral Limbs

Researchers examined the effects of bone morphogenetic protein‐2 administered locally at the time of femoral segmental bone defect surgery, and its angiogenic impacts on endothelial cellsisolated from the ipsilateral or contralateral tibia in type 2 diabetes mice.
[Journal of Orthopaedic Research]
Dadwal, U. C., Staut, C. de A., Tewari, N. P., Awosanya, O. D., Mendenhall, S. K., Valuch, C. R., Nagaraj, R. U., Blosser, R. J., Li, J., & Kacena, M. A. (n.d.). Effects of diet, BMP-2 treatment, and femoral skeletal injury on endothelial cells derived from the ipsilateral and contralateral limbs. Journal of Orthopaedic Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jor.25033 Cite
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Reduced Angiovasculogenic and Increased Inflammatory Profiles of Cord Blood Cells in Severe but Not Mild Preeclampsia

To better understand the effects of preeclampsia on angio-vasculogenesis and inflammatory networks in the fetus and to identify their biological signatures, researchers investigated the quantitative and functional characteristics of cord blood-derived mononuclear cells (MNCs) and CD31-positive MNCs.
[Scientific Reports]
Cho, S., Sohn, Y.-D., Kim, S., Rajakumar, A., Badell, M. L., Sidell, N., & Yoon, Y. (2021). Reduced angiovasculogenic and increased inflammatory profiles of cord blood cells in severe but not mild preeclampsia. Scientific Reports, 11(1), 3630. https://doi.org/10.1038/s41598-021-83146-8 Cite
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First Trimester Placental Mesenchymal Stem Cells Improve Cardiac Function of Rat after Myocardial Infarction via Enhanced Neovascularization

First trimester placental chorion mesenchymal stem cells (CMSCs) and third trimester CMSCs were isolated and characterized, and then they were subjected to in vitro endothelial cell differentiation induction and tube formation to evaluate angiogenic ability.
[Heliyon]
Yu, S., You, X., Liang, H., Li, Y., Fu, Y., Zhang, X., Hu, X., An, J., Xu, Y., & Li, F. (2021). First trimester placental mesenchymal stem cells improve cardiac function of rat after myocardial infarction via enhanced neovascularization. Heliyon, 7(1). https://doi.org/10.1016/j.heliyon.2021.e06120 Cite
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Farnesyl Dimethyl Chromanol Targets Colon Cancer Stem Cells and Prevents Colorectal Cancer Metastasis

Investigators provided the first demonstration that farnesyl dimethyl chromanol inhibited colon cancer stem cell viability, survival, self-renewal, pluripotent transcription factors expression, organoids formation, and Wnt/β-catenin signalling, as evidenced by comparisons with vehicle-treated controls.
[Scientific Reports]
Wijshake, T., Zou, Z., Chen, B., Zhong, L., Xiao, G., Xie, Y., Doench, J. G., Bennett, L., & Levine, B. (2021). Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proceedings of the National Academy of Sciences, 118(5). https://doi.org/10.1073/pnas.2020478118 Cite
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Novel Iodine Nanoparticles Target Vascular Mimicry in Intracerebral Triple Negative Human MDA-MB-231 Breast Tumors

MDA-MB-231-cells, iodine nanoparticles, and CD31 were examined by fluorescence confocal microscopy.
[Scientific Reports]
Ridwan, S. M., Hainfeld, J. F., Ross, V., Stanishevskiy, Y., & Smilowitz, H. M. (2021). Novel Iodine nanoparticles target vascular mimicry in intracerebral triple negative human MDA-MB-231 breast tumors. Scientific Reports, 11(1), 1203. https://doi.org/10.1038/s41598-020-80862-5 Cite
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Dasatinib Induces Endothelial-to-Mesenchymal Transition in Human Vascular-Endothelial Cells: Counteracted by Cotreatment with Bosutinib

The authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells.
[International Journal of Hematology]
Alkebsi, L., Wang, X., Ohkawara, H., Fukatsu, M., Mori, H., & Ikezoe, T. (2021). Dasatinib induces endothelial-to-mesenchymal transition in human vascular-endothelial cells: counteracted by cotreatment with bosutinib. International Journal of Hematology. https://doi.org/10.1007/s12185-020-03034-1 Cite
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