Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart

The authors showed for the first time that the immune response is altered as a result of syngeneic neonatal cardiomyocyte transplantation after myocardial infarction leading to improved cardiac pump function as observed by magnetic resonance imaging in C57BL/6J mice.
[Cells]
Vasudevan, P., Wolfien, M., Lemcke, H., Lang, C. I., Skorska, A., Gaebel, R., Koczan, D., Lindner, T., Engelmann, R., Vollmar, B., Krause, B. J., Wolkenhauer, O., Lang, H., Steinhoff, G., & David, R. (2020). Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells, 9(8), 1825. https://doi.org/10.3390/cells9081825 Cite
Full Article

Continue reading “Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart”

Bookmark

No account yet? Register

0
Share

ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma

Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation.
[Oncogene]
Qi, L., Wang, Z.-Y., Shao, X.-R., Li, M., Chen, S.-N., Liu, X.-Q., Yan, S., Zhang, B., Zhang, X.-D., Li, X., Zhao, W., Pan, J.-A., Zhao, B., & Zhang, X.-D. (2020). ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01411-y Cite
Abstract

Continue reading “ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma”

Bookmark

No account yet? Register

0
Share

S‐Adenosylmethionine in Combination with Decitabine Shows Enhanced Anti‐Cancer Effects in Repressing Breast Cancer Growth and Metastasis

Scientists investigated the combined therapeutic effects of an approved nutraceutical agent S‐adenosylmethionine and FDA‐approved hypomethylating agent decitabine using the MDA‐MB‐231 xenograft model of breast cancer and found a pronounced reduction in mammary tumour volume and lung metastasis compared to the animals in the control and monotherapy treatment arms.
[Journal of Cellular and Molecular Medicine]
Full Article

Continue reading “S‐Adenosylmethionine in Combination with Decitabine Shows Enhanced Anti‐Cancer Effects in Repressing Breast Cancer Growth and Metastasis”

Bookmark

No account yet? Register

0
Share

Combination Product of Dermal Matrix, Human Mesenchymal Stem Cells, and Timolol Promotes Diabetic Wound Healing in Mice

Scientists investigated whether a bioengineered scaffold device containing hypoxia‐preconditioned, allogeneic human mesenchymal stem cells combined with the beta‐adrenergic antagonist timolol could improve impaired wound healing in diabetic mice.
[Stem Cells Translational Medicine]
Yang, H., Fierro, F., So, M., Yoon, D. J., Nguyen, A. V., Gallegos, A., Bagood, M. D., Rojo‐Castro, T., Alex, A., Stewart, H., Chigbrow, M., Dasu, M. R., Peavy, T. R., Soulika, A. M., Nolta, J. A., & Isseroff, R. R. (n.d.). Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.19-0380 Cite
Full Article

Continue reading “Combination Product of Dermal Matrix, Human Mesenchymal Stem Cells, and Timolol Promotes Diabetic Wound Healing in Mice”

Bookmark

No account yet? Register

0
Share
Share