Engineered Clustered Myoblast Cell Injection Augments Angiogenesis and Muscle Regeneration in Peripheral Artery Disease

Clustered cells from myoblast cell sheets obtained from C57/BL6 mice were administered into ischemic mouse muscles seven days after induction of ischemia.
[Molecular Therapy]
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Non-Invasive Longitudinal Imaging of VEGF-Induced Microvascular Alterations in Skin Wounds

Researchers reported on non-invasive longitudinal imaging of the wound healing process in transgenic mice overexpressing vascular endothelial growth factor (VEGF) A in keratinocytes by means of large-scale optoacoustic microscopy.
[Theranostics]
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Differentiation of Cancer Stem Cells into Erythroblasts in the Presence of CoCl2

Researchers investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl2. CSCs and miPS-LLCcm cells were cultured for one to seven days in the presence of CoCl2, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed by RT-qPCR, Western blotting and flow cytometry together with Wright-Giemsa staining and immunocytochemistry.
[Scientific Reports]
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Human Umbilical Cord Mesenchymal Stem Cells Regulate CD54 and CD105 in Vascular Endothelial Cells and Suppress Inflammation in Kawasaki Disease

To explore the role of human umbilical cord mesenchymal stem cells (hucMSCs) in inhibiting endothelial inflammation in Kawasaki disease (KD), the effects of hucMSCs on the expression of CD54 and CD105 in endothelial cells in KD were analyzed in vivo and in vitro.
[Experimental Cell Research]
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NOX1 Mediates Metabolic Heart Disease in Mice and Is Upregulated in Monocytes of Humans with Diastolic Dysfunction

NOX1 mediated endothelial activation and contributed to myocardial inflammation and remodeling in metabolic disease in mice. Given its high expression in monocytes of humans with diastolic dysfunction (DD), NOX1 may represent a potential target to mitigate heart disease associated with DD.
[Cardiovascular Research]
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Desmoglein 2 Regulates Cardiogenesis by Restricting Hematopoiesis in the Developing Murine Heart

Researchers proposed that cardiomyocyte-driven paracrine signaling, which likely involves Notch1, directs subsequent trans-differentiation of endo- and epicardial cells.
[Scientific Reports]
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Natriuretic Peptide Receptor a Promotes Gastric Malignancy through Angiogenesis Process

Natriuretic peptide receptor A protected HIF-1α from proteolysis by binding to HIF-1α, increased the expression of HIF-1α, and promoted gastric cancer angiogenesis.
[Cell Death & Disease]
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Multiple Channels with Interconnected Pores in a Bioceramic Scaffold Promote Bone Tissue Formation

The authors developed a cell- and growth factor-free approach to induce bone formation in a critical-size bone defect by using an interconnected porous beta-tricalcium phosphate scaffold with multiple channels.
[Scientific Reports]
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Osteogenic and Angiogenic Profiles of the Palatal Process of the Maxilla and the Palatal Process of the Palatine Bone

The authors found that the period in which avascular mesenchymal condensation became a vascularized bone structure corresponded to embryonic day 14.5 to embyronic day 16.5 in the hard palate.
[Journal of Anatomy]
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Co-Delivery of Fibrin-Laminin Hydrogel with Mesenchymal Stem Cell Spheroids Supports Skeletal Muscle Regeneration Following Trauma

MSC aggregation into spheroids was optimized in vitro based on cellular viability, spheroid size, and trophic factor secretion. The regenerative potential of the optimized MSC spheroid therapy was then investigated in a murine model of volumetric muscle loss injury.
[Tissue Engineering and Regenerative Medicine]
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Role of Aneuploid Circulating Tumor Cells and CD31+ Circulating Tumor Endothelial Cells in Predicting and Monitoring Anti-angiogenic Therapy Efficacy in Advanced NSCLC

Co-detection and comprehensive phenotypic and karyotypic molecular characterization of aneuploid circulating tumor cells and circulating tumor endothelial cells were conducted on non-small cell lung cancer patients receiving bevacizumab plus chemotherapy.
[Molecular Oncology]
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