Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy]
Scientists tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells and hyperbaric oxygen was superior to either one on preserving neurological function and reducing brain haemorrhagic volume in rat after acute intracerebral haemorrhage induced by intracranial injection of collagenase.
[Journal of Cellular and Molecular Medicine]
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Yip, H.-K., Lin, K.-C., Sung, P.-H., Chiang, J. Y., Yin, T.-C., Wu, R.-W., & Chen, K.-H. (n.d.). Umbilical cord-derived MSC and hyperbaric oxygen therapy effectively protected the brain in rat after acute intracerebral haemorrhage. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16577 Cite
Using a vascularised lung‐on‐chip model, scientists found that infection of alveolar epithelial cells leads to limited apical release of virions, consistent with reports of monoculture infection.
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Researchers isolated human dermal microvascular endothelial cells (HDMECs) from the skin of ten patients with psoriasis and ten healthy subjects and compared angiogenesis, proliferation, migration and cell metabolism between psoriatic HDMECs and normal HDMECs.
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Li, J., Hou, H., Zhou, L., Wang, J., Liang, J., Li, J., Hou, R., Niu, X., Yin, G., Li, X., & Zhang, K. (n.d.). Increased angiogenesis and migration of dermal microvascular endothelial cells from patients with psoriasis. Experimental Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/exd.14329 Cite
Scientists investigated the effect of 5, 10, or 20% pHPL in culture media on adipose-derived stromal/stem cell proliferation and phenotypic marker expression.
[Cells Tissues Organs]
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Researchers examined the effects of bone morphogenetic protein‐2 administered locally at the time of femoral segmental bone defect surgery, and its angiogenic impacts on endothelial cellsisolated from the ipsilateral or contralateral tibia in type 2 diabetes mice.
[Journal of Orthopaedic Research]
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Dadwal, U. C., Staut, C. de A., Tewari, N. P., Awosanya, O. D., Mendenhall, S. K., Valuch, C. R., Nagaraj, R. U., Blosser, R. J., Li, J., & Kacena, M. A. (n.d.). Effects of diet, BMP-2 treatment, and femoral skeletal injury on endothelial cells derived from the ipsilateral and contralateral limbs. Journal of Orthopaedic Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jor.25033 Cite
To better understand the effects of preeclampsia on angio-vasculogenesis and inflammatory networks in the fetus and to identify their biological signatures, researchers investigated the quantitative and functional characteristics of cord blood-derived mononuclear cells (MNCs) and CD31-positive MNCs.
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First trimester placental chorion mesenchymal stem cells (CMSCs) and third trimester CMSCs were isolated and characterized, and then they were subjected to in vitro endothelial cell differentiation induction and tube formation to evaluate angiogenic ability.
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Yu, S., You, X., Liang, H., Li, Y., Fu, Y., Zhang, X., Hu, X., An, J., Xu, Y., & Li, F. (2021). First trimester placental mesenchymal stem cells improve cardiac function of rat after myocardial infarction via enhanced neovascularization. Heliyon, 7(1). https://doi.org/10.1016/j.heliyon.2021.e06120 Cite
Investigators provided the first demonstration that farnesyl dimethyl chromanol inhibited colon cancer stem cell viability, survival, self-renewal, pluripotent transcription factors expression, organoids formation, and Wnt/β-catenin signalling, as evidenced by comparisons with vehicle-treated controls.
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MDA-MB-231-cells, iodine nanoparticles, and CD31 were examined by fluorescence confocal microscopy.
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The authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells.
[International Journal of Hematology]
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Alkebsi, L., Wang, X., Ohkawara, H., Fukatsu, M., Mori, H., & Ikezoe, T. (2021). Dasatinib induces endothelial-to-mesenchymal transition in human vascular-endothelial cells: counteracted by cotreatment with bosutinib. International Journal of Hematology. https://doi.org/10.1007/s12185-020-03034-1 Cite