Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
You, J., Zhou, O., Liu, J., Zou, W., Zhang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Fu, Z., & Zou, L. (2020). Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0156 Cite
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Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo

Adult scalp dermal progenitor cells and epidermal stem cells together with type I collagen as a scaffold material were used to reconstitute bilayer tissue-engineered skin substitutes in vitro.
[Stem Cell Research & Therapy]
Zhang, Q., Wen, J., Liu, C., Ma, C., Bai, F., Leng, X., Chen, Z., Xie, Z., Mi, J., & Wu, X. (2020). Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo. Stem Cell Research & Therapy, 11(1), 407. https://doi.org/10.1186/s13287-020-01924-z Cite
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Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer

Because of the hypoxic nature of solid tumors, researchers investigated if oxygen, via hypoxia-inducible transcription factors HIF-1α and HIF-2α, regulated tie2-expressing monocytes/macrophages function in the hypoxic tumor microenvironment.
[Journal of Immunology]
Steinberger, K. J., Forget, M. A., Bobko, A. A., Mihalik, N. E., Gencheva, M., Roda, J. M., Cole, S. L., Mo, X., Hoblitzell, E. H., Evans, R., Gross, A. C., Moldovan, L., Marsh, C. B., Khramstov, V. V., & Eubank, T. D. (2020). Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2000185 Cite
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iPSC-Derived Endothelial Networks Accelerate Vascularization but Not Bone Regeneration

Vascular networks were generated from endothelial cells (ECs) derived from human iPSCs. Network formation by iPSC-ECs within fibrin gels was investigated in a mesenchymal stem cell co-culture spheroid model.
[Tissue Engineering]
Roux, B. M., Vaicik, M., Shrestha, B., Montelongo, S., Stojkova, K., Yang, F., Guda, T., Cinar, A., & Brey, E. M. (2020). iPSC-derived endothelial networks accelerate vascularization but not bone regeneration. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0200 Cite
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Adipose Stem Cells and PRP Induce Vascular-Like Structures in a Dermal Regeneration Template

Integra® Dermal Regeneration Template was sprinkled with adipose-derived stem cells in complete medium supplemented with 10% Fetal Bovine Serum, or stromal vascular fraction, obtained from emulsified or non-emulsified fat, in medium supplemented with 2% platelet-rich plasma.
[Tissue Engineering]
Beccia, E., Carbone, A., Cecchino, L. R., Pedicillo, M. C., Annacontini, L., Lembo, F., Di Gioia, S., Parisi, D., Angiolillo, A., Pannone, G., Portincasa, A., & Conese, M. (2020). Adipose stem cells and PRP induce vascular-like structures in a Dermal Regeneration Template. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0175 Cite
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Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart

The authors showed for the first time that the immune response is altered as a result of syngeneic neonatal cardiomyocyte transplantation after myocardial infarction leading to improved cardiac pump function as observed by magnetic resonance imaging in C57BL/6J mice.
[Cells]
Vasudevan, P., Wolfien, M., Lemcke, H., Lang, C. I., Skorska, A., Gaebel, R., Koczan, D., Lindner, T., Engelmann, R., Vollmar, B., Krause, B. J., Wolkenhauer, O., Lang, H., Steinhoff, G., & David, R. (2020). Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart. Cells, 9(8), 1825. https://doi.org/10.3390/cells9081825 Cite
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ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma

Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation.
[Oncogene]
Qi, L., Wang, Z.-Y., Shao, X.-R., Li, M., Chen, S.-N., Liu, X.-Q., Yan, S., Zhang, B., Zhang, X.-D., Li, X., Zhao, W., Pan, J.-A., Zhao, B., & Zhang, X.-D. (2020). ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01411-y Cite
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S‐Adenosylmethionine in Combination with Decitabine Shows Enhanced Anti‐Cancer Effects in Repressing Breast Cancer Growth and Metastasis

Scientists investigated the combined therapeutic effects of an approved nutraceutical agent S‐adenosylmethionine and FDA‐approved hypomethylating agent decitabine using the MDA‐MB‐231 xenograft model of breast cancer and found a pronounced reduction in mammary tumour volume and lung metastasis compared to the animals in the control and monotherapy treatment arms.
[Journal of Cellular and Molecular Medicine]
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Combination Product of Dermal Matrix, Human Mesenchymal Stem Cells, and Timolol Promotes Diabetic Wound Healing in Mice

Scientists investigated whether a bioengineered scaffold device containing hypoxia‐preconditioned, allogeneic human mesenchymal stem cells combined with the beta‐adrenergic antagonist timolol could improve impaired wound healing in diabetic mice.
[Stem Cells Translational Medicine]
Yang, H., Fierro, F., So, M., Yoon, D. J., Nguyen, A. V., Gallegos, A., Bagood, M. D., Rojo‐Castro, T., Alex, A., Stewart, H., Chigbrow, M., Dasu, M. R., Peavy, T. R., Soulika, A. M., Nolta, J. A., & Isseroff, R. R. (n.d.). Combination product of dermal matrix, human mesenchymal stem cells, and timolol promotes diabetic wound healing in mice. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.19-0380 Cite
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