Novel Iodine Nanoparticles Target Vascular Mimicry in Intracerebral Triple Negative Human MDA-MB-231 Breast Tumors

MDA-MB-231-cells, iodine nanoparticles, and CD31 were examined by fluorescence confocal microscopy.
[Scientific Reports]
Ridwan, S. M., Hainfeld, J. F., Ross, V., Stanishevskiy, Y., & Smilowitz, H. M. (2021). Novel Iodine nanoparticles target vascular mimicry in intracerebral triple negative human MDA-MB-231 breast tumors. Scientific Reports, 11(1), 1203. https://doi.org/10.1038/s41598-020-80862-5 Cite
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Dasatinib Induces Endothelial-to-Mesenchymal Transition in Human Vascular-Endothelial Cells: Counteracted by Cotreatment with Bosutinib

The authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells.
[International Journal of Hematology]
Alkebsi, L., Wang, X., Ohkawara, H., Fukatsu, M., Mori, H., & Ikezoe, T. (2021). Dasatinib induces endothelial-to-mesenchymal transition in human vascular-endothelial cells: counteracted by cotreatment with bosutinib. International Journal of Hematology. https://doi.org/10.1007/s12185-020-03034-1 Cite
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Endothelial Progenitor/Stem Cells in Engineered Vessels for Vascular Transplantation

Umbilical-cord blood vessels were isolated for decellularization and to establish endothelial cell culture. Cultured cells were characterized by immunophenotype, gene expression and in vitro angiogenesis assay.
[Journal of Materials Science-Materials in Medicine]
Muniswami, D. M., Reddy, L. V. K., Amirtham, S. M., Babu, S., Raj, A. N., Sen, D., & Manivasagam, G. (2020). Endothelial progenitor/stem cells in engineered vessels for vascular transplantation. Journal of Materials Science: Materials in Medicine, 31(12), 119. https://doi.org/10.1007/s10856-020-06458-7 Cite
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Omega-3 Eicosapentaenoic Acid Reduces Prostate Tumor Vascularity

Testing autocrine and paracrine effects in an avascular tumor spheroid growth assay, both exogenous monoacylglyceride-conjugated form of eicosapentaenoic acid and endogenous ω3 reduced VEGF secretion and in vitro endothelial cell tube formation and blocked tumor spheroid growth, suggesting that ω3 molecules could directly hinder prostate cancer cell growth.
[Molecular Cancer Research]
Gevariya, N., Lachance, G., Robitaille, K., Beauparlant, C. J., Beaudoin, L., Fournier, E., Fradet, Y., Droit, A., Julien, P., Marette, A., Bergeron, A., & Fradet, V. (2020). Omega-3 Eicosapentaenoic Acid Reduces Prostate Tumor Vascularity. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0316 Cite
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Silk Fibroin Vascular Graft: A Promising Tissue-Engineered Scaffold Material for Abdominal Venous System Replacement

The authors focused on the development of new tissue-engineered vascular graft using a silk-based scaffold material for abdominal venous system replacement. A rat vein, the inferior vena cava, was replaced by a silk fibroin tissue-engineered vascular graft.
[Scientific Reports]
Kiritani, S., Kaneko, J., Ito, D., Morito, M., Ishizawa, T., Akamatsu, N., Tanaka, M., Iida, T., Tanaka, T., Tanaka, R., Asakura, T., Arita, J., & Hasegawa, K. (2020). Silk fibroin vascular graft: a promising tissue-engineered scaffold material for abdominal venous system replacement. Scientific Reports, 10(1), 21041. https://doi.org/10.1038/s41598-020-78020-y Cite
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Definitive Hematopoietic Stem/Progenitor Cells from Human Embryonic Stem Cells through Serum/Feeder-Free Organoid-Induced Differentiation

To derive definitive hematopoietic stem/precursor cells from human embryonic stem cells, researchers differentiated mesodermally specified embryoid bodies on gelatin-coated plates in serum/feeder-free conditions.
[Stem Cell Research & Therapy]
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Definitive Hematopoietic Stem/Progenitor Cells from Human Embryonic Stem Cells through Serum/Feeder-Free Organoid-Induced Differentiation

To derive definitive hematopoietic stem/precursor cells from human embryonic stem cells, scientists differentiated mesodermally specified embryoid bodies on gelatin-coated plates in serum/feeder-free conditions.
[Stem Cell Research & Therapy]
Demirci, S., Haro-Mora, J. J., Leonard, A., Drysdale, C., Malide, D., Keyvanfar, K., Essawi, K., Vizcardo, R., Tamaoki, N., Restifo, N. P., Tisdale, J. F., & Uchida, N. (2020). Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation. Stem Cell Research & Therapy, 11(1), 493. https://doi.org/10.1186/s13287-020-02019-5 Cite
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Targeting Tumor Cell-Derived CCL2 as a Strategy to Overcome Bevacizumab Resistance in ETV5+ Colorectal Cancer

Gene set enrichment analysis and additional assays confirmed that ETV5 could promote angiogenesis by inducing the secretion of another tumor angiogenesis factor (CCL2) in CRC cells to facilitate Bevacizumab resistance.
[Cell Death & Disease]
Feng, H., Liu, K., Shen, X., Liang, J., Wang, C., Qiu, W., Cheng, X., & Zhao, R. (2020). Targeting tumor cell-derived CCL2 as a strategy to overcome Bevacizumab resistance in ETV5 + colorectal cancer. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03111-7 Cite
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
You, J., Zhou, O., Liu, J., Zou, W., Zhang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Fu, Z., & Zou, L. (2020). Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0156 Cite
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Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo

Adult scalp dermal progenitor cells and epidermal stem cells together with type I collagen as a scaffold material were used to reconstitute bilayer tissue-engineered skin substitutes in vitro.
[Stem Cell Research & Therapy]
Zhang, Q., Wen, J., Liu, C., Ma, C., Bai, F., Leng, X., Chen, Z., Xie, Z., Mi, J., & Wu, X. (2020). Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo. Stem Cell Research & Therapy, 11(1), 407. https://doi.org/10.1186/s13287-020-01924-z Cite
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Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer

Because of the hypoxic nature of solid tumors, researchers investigated if oxygen, via hypoxia-inducible transcription factors HIF-1α and HIF-2α, regulated tie2-expressing monocytes/macrophages function in the hypoxic tumor microenvironment.
[Journal of Immunology]
Steinberger, K. J., Forget, M. A., Bobko, A. A., Mihalik, N. E., Gencheva, M., Roda, J. M., Cole, S. L., Mo, X., Hoblitzell, E. H., Evans, R., Gross, A. C., Moldovan, L., Marsh, C. B., Khramstov, V. V., & Eubank, T. D. (2020). Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2000185 Cite
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