Researchers investigated transcriptional and functional heterogeneity of human tissue-resident memory T (TRM) cells through study of donor-derived TRM cells from intestinal transplant recipients.
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FitzPatrick, M. E. B., Provine, N. M., Garner, L. C., Powell, K., Amini, A., Irwin, S. L., Ferry, H., Ambrose, T., Friend, P., Vrakas, G., Reddy, S., Soilleux, E., Klenerman, P., & Allan, P. J. (2021). Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets. Cell Reports, 34(3). https://doi.org/10.1016/j.celrep.2020.108661 Cite
Scientists showed that, unlike whole-cell pertussis vaccines, acellular pertussis vaccines, while protective against lung colonization by Bordetella pertussis, did not protect BALB/c mice from nasal colonization, but instead substantially prolonged nasal carriage.
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Dubois, V., Chatagnon, J., Thiriard, A., Bauderlique-Le Roy, H., Debrie, A.-S., Coutte, L., & Locht, C. (2021). Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage. Npj Vaccines, 6(1), 1–10. https://doi.org/10.1038/s41541-020-00270-8 Cite
Using high-dimensional analysis of human adoptive T cell therapy products, scientists identified a memory-progenitor CD39-negative stem-like phenotype associated with complete cancer regression and tumor-infiltrating lymphocyte (TIL) persistence and a terminally differentiated CD39-positive state associated with poor TIL persistence.
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Krishna, S., Lowery, F. J., Copeland, A. R., Bahadiroglu, E., Mukherjee, R., Jia, L., Anibal, J. T., Sachs, A., Adebola, S. O., Gurusamy, D., Yu, Z., Hill, V., Gartner, J. J., Li, Y. F., Parkhurst, M., Paria, B., Kvistborg, P., Kelly, M. C., Goff, S. L., … Rosenberg, S. A. (2020). Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer. Science, 370(6522), 1328–1334. https://doi.org/10.1126/science.abb9847 Cite
Scientists discuss the roles of immunomodulatory receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases.
[Cellular & Molecular Immunology]
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Researchers examined immune cell subsets in hospitalized and non-hospitalized individuals. In hospitalized patients, many adaptive and innate immune cells were decreased in frequency compared to healthy and convalescent individuals, with the exception of B lymphocytes which increased
[Journal of Clinical Investigation]
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Files, J. K., Boppana, S., Perez, M. D., Sarkar, S., Lowman, K. E., Qin, K., Sterrett, S., Carlin, E., Bansal, A., Sabbaj, S., Long, D. M., Kutsch, O., Kobie, J., Goepfert, P., & Erdmann, N. (2020). Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140491 Cite
Researchers used T-cell receptor β chain (sequencing to study the T-cell repertoire in the coronary artery, endomyocardium, and peripheral blood at the time of retransplant in four cases of cardiac allograft vasculopathy and compared it to the immunoglobulin heavy chain repertoire from the same samples.
[American Journal of Transplantation]
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Habal, M. V., Miller, A. M. I., Rao, S., Lin, S., Obradovic, A., Khosravi‐Maharlooei, M., See, S., Roy, P., Ronzon, S., Ho, S., Marboe, C., Naka, Y., Takeda, K., Restaino, S., Han, A., Mancini, D., Givertz, M., C.Madsen, J., Sykes, M., … Zorn, E. (n.d.). T cell repertoire analysis suggest a prominent bystander response in human cardiac allograft vasculopathy. American Journal of Transplantation, n/a(n/a). https://doi.org/10.1111/ajt.16333 Cite
Normal human kidneys were obtained from radically nephrectomised patients with urogenital malignancy. Subsequently, human kidney immune cell subsets were analysed using multicolor flow cytometry and compared with subsets from C57BL/6 or BALB/c mice under specific pathogen-free conditions.
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With murine and humanized MHC–/–HLA-A2+DR4+ murine models of chronic graft-versus-host disease (cGVHD), researchers showed that both murine and human PSGL1loCD4+ T cells from GVHD target tissues have features of B cell helpers with upregulated-expression of PD1 and ICOS and production of IL-21.
[Journal of Clinical Investigation]
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Data sets revealed that B cells in the blood were not in homeostasis with compartments in other tissues. Investigators found striking donor-to-donor variability in the frequencies and isotype of CD27+ memory B cells
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Allografts were rapidly infiltrated by recipient leukocytes, which recapitulated the liver myeloid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on MNPs and CD69/CD103 on T cells.
[Journal of Experimental Medicine]
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