Tag Archives: CD69

Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15

Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
[Stem Cell Reports]
Song, C., Xu, W., Wu, H., Wang, X., Gong, Q., Liu, C., Liu, J., & Zhou, L. (2020). Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03136-y Cite
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Intestinal CD8+ T Cell Responses Are Abundantly Induced Early in Human Development but Show Impaired Cytotoxic Effector Capacities

Researchers investigated the maturation of the CD8+ T cell compartment in human fetal, infant and adult intestinal tissues. CD8+ T cells exhibiting a memory phenotype were already detected in fetal intestines and increased after birth.
[Mucosal Immunology]
Schreurs, R. R. C. E., Sagebiel, A. F., Steinert, F. L., Highton, A. J., Klarenbeek, P. L., Drewniak, A., Bakx, R., The, S. M. L., Ribeiro, C. M. S., Perez, D., Reinshagen, K., Geijtenbeek, T. B. H., van Goudoever, J. B., & Bunders, M. J. (2021). Intestinal CD8 + T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities. Mucosal Immunology, 1–10. https://doi.org/10.1038/s41385-021-00382-x Cite
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Monocyte-Derived S1P in the Lymph Node Regulates Immune Responses

Researchers showed that the concentration of sphingosine 1-phosphate (S1P) increased in lymph nodes during an immune response.
[Nature]
Baeyens, A., Bracero, S., Chaluvadi, V. S., Khodadadi-Jamayran, A., Cammer, M., & Schwab, S. R. (2021). Monocyte-derived S1P in the lymph node regulates immune responses. Nature, 1–6. https://doi.org/10.1038/s41586-021-03227-6 Cite
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Differential Expression of CD49a and CD49b Determines Localization and Function of Tumor-Infiltrating CD8+ T Cells

Researchers found that tumor-infiltrating CD8+ T cells initially expressed CD49b, gained CD49a, and then lost CD49b over the course of tumor outgrowth.
[Cancer Immunology Research]
Melssen, M. M., Lindsay, R. S., Stasiak, K., Rodriguez, A. B., Briegel, A. M., Cyranowski, S., Rutkowski, M. R., Conaway, M. R., Melief, C. J., Burg, S. H. van der, Eyo, U., Slingluff, C. L., & Engelhard, V. H. (2021). Differential expression of CD49a and CD49b determines localization and function of tumor-infiltrating CD8+ T cells. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0427 Cite
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Single-Cell Analysis Shows That Adipose Tissue of Persons with Both HIV and Diabetes Is Enriched for Clonal, Cytotoxic, and CMV-Specific CD4+ T Cells

Persons with HIV and diabetes have a high proportion of CX3CR1+ GPR56+ CD57+ (C-G-C+) CD4+ T cells in adipose tissue, a subset of which are cytomegalovirus specific, whereas individuals with diabetes but without HIV have predominantly CD69+ CD4+ T cells.
[Cell Reports Medicine]
Wanjalla, C. N., McDonnell, W. J., Ram, R., Chopra, A., Gangula, R., Leary, S., Mashayekhi, M., Simmons, J. D., Warren, C. M., Bailin, S., Gabriel, C. L., Guo, L., Furch, B. D., Lima, M. C., Woodward, B. O., Hannah, L., Pilkinton, M. A., Fuller, D. T., Kawai, K., … Koethe, J. R. (2021). Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells. Cell Reports Medicine, 2(2). https://doi.org/10.1016/j.xcrm.2021.100205 Cite
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Selective Recruitment of γδ T Cells by a Bispecific Antibody for the Treatment of Acute Myeloid Leukemia

Scientists designed an alternative engager molecule, a bispecific antibody that could simultaneously bind to the Vγ9 chain of the Vγ9Vδ2+ γδ T cell receptor and to AML target antigen, CD123, to selectively recruit Vγ9+ γδ T cells rather than pan T cells to target AML blasts.
[Leukemia]
Ganesan, R., Chennupati, V., Ramachandran, B., Hansen, M. R., Singh, S., & Grewal, I. S. (2021). Selective recruitment of γδ T cells by a bispecific antibody for the treatment of acute myeloid leukemia. Leukemia, 1–11. https://doi.org/10.1038/s41375-021-01122-7 Cite
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Human Intestinal Tissue-Resident Memory T Cells Comprise Transcriptionally and Functionally Distinct Subsets

Researchers investigated transcriptional and functional heterogeneity of human tissue-resident memory T (TRM) cells through study of donor-derived TRM cells from intestinal transplant recipients.
[Cell Reports]
FitzPatrick, M. E. B., Provine, N. M., Garner, L. C., Powell, K., Amini, A., Irwin, S. L., Ferry, H., Ambrose, T., Friend, P., Vrakas, G., Reddy, S., Soilleux, E., Klenerman, P., & Allan, P. J. (2021). Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets. Cell Reports, 34(3). https://doi.org/10.1016/j.celrep.2020.108661 Cite
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Suppression of Mucosal Th17 Memory Responses by Acellular Pertussis Vaccines Enhances Nasal Bordetella pertussis Carriage

Scientists showed that, unlike whole-cell pertussis vaccines, acellular pertussis vaccines, while protective against lung colonization by Bordetella pertussis, did not protect BALB/c mice from nasal colonization, but instead substantially prolonged nasal carriage.
[npj Vaccines]
Dubois, V., Chatagnon, J., Thiriard, A., Bauderlique-Le Roy, H., Debrie, A.-S., Coutte, L., & Locht, C. (2021). Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage. Npj Vaccines, 6(1), 1–10. https://doi.org/10.1038/s41541-020-00270-8 Cite
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Stem-Like CD8 T Cells Mediate Response of Adoptive Cell Immunotherapy Against Human Cancer

Using high-dimensional analysis of human adoptive T cell therapy products, scientists identified a memory-progenitor CD39-negative stem-like phenotype associated with complete cancer regression and tumor-infiltrating lymphocyte (TIL) persistence and a terminally differentiated CD39-positive state associated with poor TIL persistence.
[Science]
Krishna, S., Lowery, F. J., Copeland, A. R., Bahadiroglu, E., Mukherjee, R., Jia, L., Anibal, J. T., Sachs, A., Adebola, S. O., Gurusamy, D., Yu, Z., Hill, V., Gartner, J. J., Li, Y. F., Parkhurst, M., Paria, B., Kvistborg, P., Kelly, M. C., Goff, S. L., … Rosenberg, S. A. (2020). Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer. Science, 370(6522), 1328–1334. https://doi.org/10.1126/science.abb9847 Cite
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Novel Human Immunomodulatory T Cell Receptors and Their Double-Edged Potential in Autoimmunity, Cardiovascular Disease and Cancer

Scientists discuss the roles of immunomodulatory receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases.
[Cellular & Molecular Immunology]
Martín, P., Blanco-Domínguez, R., & Sánchez-Díaz, R. (2020). Novel human immunomodulatory T cell receptors and their double-edged potential in autoimmunity, cardiovascular disease and cancer. Cellular & Molecular Immunology, 1–17. https://doi.org/10.1038/s41423-020-00586-4 Cite
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Sustained Cellular Immune Dysregulation in Individuals Recovering from SARS-CoV-2 Infection

Researchers examined immune cell subsets in hospitalized and non-hospitalized individuals. In hospitalized patients, many adaptive and innate immune cells were decreased in frequency compared to healthy and convalescent individuals, with the exception of B lymphocytes which increased
[Journal of Clinical Investigation]
Files, J. K., Boppana, S., Perez, M. D., Sarkar, S., Lowman, K. E., Qin, K., Sterrett, S., Carlin, E., Bansal, A., Sabbaj, S., Long, D. M., Kutsch, O., Kobie, J., Goepfert, P., & Erdmann, N. (2020). Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140491 Cite
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