Tag Archives: CD69

Immune Cell Composition in Normal Human Kidneys

Normal human kidneys were obtained from radically nephrectomised patients with urogenital malignancy. Subsequently, human kidney immune cell subsets were analysed using multicolor flow cytometry and compared with subsets from C57BL/6 or BALB/c mice under specific pathogen-free conditions.
[Scientific Reports]
Park, J.-G., Na, M., Kim, M.-G., Park, S. H., Lee, H. J., Kim, D. K., Kwak, C., Kim, Y. S., Chang, S., Moon, K. C., Lee, D.-S., & Han, S. S. (2020). Immune cell composition in normal human kidneys. Scientific Reports, 10(1), 15678. https://doi.org/10.1038/s41598-020-72821-x Cite
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Tissue-Resident PSGL1loCD4+ T Cells Promote B Cell Differentiation and Chronic Graft-versus-Host-Disease-Associated Autoimmunity

With murine and humanized MHC–/–HLA-A2+DR4+ murine models of chronic graft-versus-host disease (cGVHD), researchers showed that both murine and human PSGL1loCD4+ T cells from GVHD target tissues have features of B cell helpers with upregulated-expression of PD1 and ICOS and production of IL-21.
[Journal of Clinical Investigation]
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Comprehensive Analyses of B Cell Compartments across the Human Body Reveal Novel Subsets and a Gut Resident Memory Phenotype

Data sets revealed that B cells in the blood were not in homeostasis with compartments in other tissues. Investigators found striking donor-to-donor variability in the frequencies and isotype of CD27+ memory B cells
[Blood]
Weisel, N. M., Weisel, F. J., Farber, D. L., Borghesi, L., Shen, Y., Ma, W., Luning Prak, E. T., & Shlomchik, M. (n.d.). Comprehensive analyses of B cell compartments across the human body reveal novel subsets and a gut resident memory phenotype. Blood. https://doi.org/10.1182/blood.2019002782 Cite
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Longevity and Replenishment of Human Liver-Resident Memory T Cells and Mononuclear Phagocytes

Allografts were rapidly infiltrated by recipient leukocytes, which recapitulated the liver myeloid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on MNPs and CD69/CD103 on T cells.
[Journal of Experimental Medicine]
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