Tag Archives: CD69

Immune Modulation via Adipose Derived Mesenchymal Stem Cells Is Driven by Donor Sex In Vitro

The authors examined the potency and functionality of both female and male adipose derived mesenchymal stem cells in order to gain further insights into donor selection.
[Scientific Reports]
Mckinnirey, F., Herbert, B., Vesey, G., & McCracken, S. (2021). Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro. Scientific Reports, 11(1), 12454. https://doi.org/10.1038/s41598-021-91870-4 Cite
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Activated Natural Killer Cells Predict Poor Clinical Prognosis in High-Risk B- and T-Cell Acute Lymphoblastic Leukemia

Researchers delineated the phenotypic and functional defects in NK cells of high-risk B- and T- cell acute lymphoblastic leukemia (ALL) patients using mass, flow, and in silico cytometry, with the goal of further elucidating the role of NK cells in sustaining ALL regression.
[Blood]
Duault, C., Kumar, A., Taghi Khani, A., Lee, S. J., Yang, L., Huang, M., Hurtz, C., Manning, B., Ghoda, L. Y., McDonald, T., Lacayo, N. J., Sakamoto, K. M., Carroll, M. P., Tasian, S. K., Marcucci, G., Yu, J., Caligiuri, M. A., Maecker, H. T., & Swaminathan, S. (2021). Activated Natural Killer Cells Predict Poor Clinical Prognosis in High-risk B- and T- cell Acute Lymphoblastic Leukemia. Blood, blood.2020009871. https://doi.org/10.1182/blood.2020009871 Cite
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Oleoylethanolamide Induces Eosinophilic Airway Inflammation in Bronchial Asthma

To investigate the effect of OEA, the expression of proinflammatory cytokines was measured by RT-qPCR and ELISA in airway epithelial (A549) cells.
[Experimental and Molecular Medicine]
Kwon, E.-K., Choi, Y., Yoon, I.-H., Won, H.-K., Sim, S., Lee, H.-R., Kim, H. S., Ye, Y.-M., Shin, Y. S., Park, H.-S., & Ban, G.-Y. (2021). Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma. Experimental & Molecular Medicine, 1–10. https://doi.org/10.1038/s12276-021-00622-x Cite
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Lung-Resident Memory B Cells Protect against Bacterial Pneumonia

Investigators examined whether lung lung-resident memory B cells cells were elicited by the respiratory pathogen pneumococcus, were present in humans, and were important in pneumonia defense
[Journal of Clinical Investigation]
Barker, K. A., Etesami, N. S., Shenoy, A. T., Arafa, E. I., Ana, C. L. de, Smith, N. M. S., Martin, I. M. C., Goltry, W. N., Barron, A. M. S., Browning, J. L., Kathuria, H., Belkina, A. C., Guillon, A., Zhong, X., Crossland, N. A., Jones, M. R., Quinton, L. J., & Mizgerd, J. P. (2021). Lung-resident memory B cells protect against bacterial pneumonia. The Journal of Clinical Investigation, 131(11). https://doi.org/10.1172/JCI141810 Cite
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Induction of the Apoptosis, Degranulation and IL-13 Production of Human Basophils by Butyrate and Propionate via Suppression of Histone Deacetylation

Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
[British Journal of Immunology]
Shi, Y., Xu, M., Pan, S., Gao, S., Ren, J., Bai, R., Li, H., He, C., Zhao, S., Shi, Z., Yu, F., Xiang, Z., & Wang, H. (n.d.). Induction of the apoptosis, degranulation and IL-13 production of human basophils by butyrate and propionate via suppression of histone deacetylation. Immunology, n/a(n/a). https://doi.org/https://doi.org/10.1111/imm.13370 Cite
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The Human Memory T Cell Compartment Changes across Tissues of the Female Reproductive Tract

Scientists examined CD4 T cells in donor-matched vaginal, ecto- and endocervical tissues, which differ in mucosal structure and exposure to external environmental stimuli.
[Mucosal Immunology]
Woodward Davis, A. S., Vick, S. C., Pattacini, L., Voillet, V., Hughes, S. M., Lentz, G. M., Kirby, A. C., Fialkow, M. F., Gottardo, R., Hladik, F., Lund, J. M., & Prlic, M. (2021). The human memory T cell compartment changes across tissues of the female reproductive tract. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-021-00406-6 Cite
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Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15

Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
[Stem Cell Reports]
Song, C., Xu, W., Wu, H., Wang, X., Gong, Q., Liu, C., Liu, J., & Zhou, L. (2020). Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03136-y Cite
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Intestinal CD8+ T Cell Responses Are Abundantly Induced Early in Human Development but Show Impaired Cytotoxic Effector Capacities

Researchers investigated the maturation of the CD8+ T cell compartment in human fetal, infant and adult intestinal tissues. CD8+ T cells exhibiting a memory phenotype were already detected in fetal intestines and increased after birth.
[Mucosal Immunology]
Schreurs, R. R. C. E., Sagebiel, A. F., Steinert, F. L., Highton, A. J., Klarenbeek, P. L., Drewniak, A., Bakx, R., The, S. M. L., Ribeiro, C. M. S., Perez, D., Reinshagen, K., Geijtenbeek, T. B. H., van Goudoever, J. B., & Bunders, M. J. (2021). Intestinal CD8 + T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities. Mucosal Immunology, 1–10. https://doi.org/10.1038/s41385-021-00382-x Cite
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Monocyte-Derived S1P in the Lymph Node Regulates Immune Responses

Researchers showed that the concentration of sphingosine 1-phosphate (S1P) increased in lymph nodes during an immune response.
[Nature]
Baeyens, A., Bracero, S., Chaluvadi, V. S., Khodadadi-Jamayran, A., Cammer, M., & Schwab, S. R. (2021). Monocyte-derived S1P in the lymph node regulates immune responses. Nature, 1–6. https://doi.org/10.1038/s41586-021-03227-6 Cite
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Differential Expression of CD49a and CD49b Determines Localization and Function of Tumor-Infiltrating CD8+ T Cells

Researchers found that tumor-infiltrating CD8+ T cells initially expressed CD49b, gained CD49a, and then lost CD49b over the course of tumor outgrowth.
[Cancer Immunology Research]
Melssen, M. M., Lindsay, R. S., Stasiak, K., Rodriguez, A. B., Briegel, A. M., Cyranowski, S., Rutkowski, M. R., Conaway, M. R., Melief, C. J., Burg, S. H. van der, Eyo, U., Slingluff, C. L., & Engelhard, V. H. (2021). Differential expression of CD49a and CD49b determines localization and function of tumor-infiltrating CD8+ T cells. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0427 Cite
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Single-Cell Analysis Shows That Adipose Tissue of Persons with Both HIV and Diabetes Is Enriched for Clonal, Cytotoxic, and CMV-Specific CD4+ T Cells

Persons with HIV and diabetes have a high proportion of CX3CR1+ GPR56+ CD57+ (C-G-C+) CD4+ T cells in adipose tissue, a subset of which are cytomegalovirus specific, whereas individuals with diabetes but without HIV have predominantly CD69+ CD4+ T cells.
[Cell Reports Medicine]
Wanjalla, C. N., McDonnell, W. J., Ram, R., Chopra, A., Gangula, R., Leary, S., Mashayekhi, M., Simmons, J. D., Warren, C. M., Bailin, S., Gabriel, C. L., Guo, L., Furch, B. D., Lima, M. C., Woodward, B. O., Hannah, L., Pilkinton, M. A., Fuller, D. T., Kawai, K., … Koethe, J. R. (2021). Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells. Cell Reports Medicine, 2(2). https://doi.org/10.1016/j.xcrm.2021.100205 Cite
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