CD8

[Cell Discovery] In non-human primates, CoVac501 elicited high and persistent titers of protective neutralizing antibodies against multiple receptor-binding domain mutations, SARS-CoV-2 original strain, and variants.

[Cancer Cell] Researchers proposed that lactic acid in the highly glycolytic tumor microenvironment (TME) was an active checkpoint for the function of regulatory T cells in the TME via upregulation of PD-1 expression.

[iScience] Scientists generated a doxycycline inducible MHC-I and II antigen expressing HCC cell line which allowed them to investigate tumor antigen specific T cell response in two non-alcoholic fatty liver disease (NAFLD) mouse models.

[Nature Immunology] Scientists found that CCR6+ type 3 innate lymphoid cells could trigger an increase in the number of T cells infiltrating a tumor.

[Developmental Cell] Scientists reported that the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) co-localized with programmed death ligand 1 (PD-L1) on the exosomes; both ICAM-1 and PD-L1 were upregulated by interferon-γ.

[Cell Death Discovery] Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, the authors identified ten major cell types and 19 unique subtypes.