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CD8

Single-Cell RNA Sequencing Coupled to TCR Profiling of Large Granular Lymphocyte Leukemia T Cells

[Nature Communications] Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.

Neoantigen-Specific CD8 T Cell Responses in the Peripheral Blood Following PD-L1 Blockade Might Predict Therapy Outcome in Metastatic Urothelial Carcinoma

[Nature Communications] The authors showed that broadening the number of neoantigen-reactive CD8+ T cell populations between pre-treatment to three weeks post-treatment distinguished patients with controlled disease compared to patients with progressive disease in metastatic urothelial carcinoma treated with PD-L1-blockade.

Distinct Molecular and Immune Hallmarks of Inflammatory Arthritis Induced by Immune Checkpoint Inhibitors for Cancer Therapy

[Nature Communications] Investigators comprehensively analyzed peripheral blood and/or synovial fluid samples from 20 patients with immune-related adverse events, including arthritis, and unmasked a prominent Th1-CD8+ T cell axis in both blood and inflamed joints.

LPA Suppresses T Cell Function by Altering the Cytoskeleton and Disrupting Immune Synapse Formation

[Proceedings of the National Academy of Sciences of the United States of America] The authors suggested that targeting lysophosphatidic acid (LPA) signaling in chronic inflammatory conditions may have rescued T cell function and promoted antiviral and antitumor immunity.

Single-Cell RNA Sequencing Coupled to TCR Profiling of Large Granular Lymphocyte Leukemia T Cells

[Nature Communications] Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.

Neoantigen-Specific CD8 T Cell Responses in the Peripheral Blood Following PD-L1 Blockade Might Predict Therapy Outcome in Metastatic Urothelial Carcinoma

[Nature Communications] The authors showed that broadening the number of neoantigen-reactive CD8+ T cell populations between pre-treatment to three weeks post-treatment distinguished patients with controlled disease compared to patients with progressive disease in metastatic urothelial carcinoma treated with PD-L1-blockade.

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