Atovaquone-HSA Nano-Drugs Enhance the Efficacy of PD-1 Blockade Immunotherapy by Alleviating Hypoxic Tumor Microenvironment

The authors exploited atovaquone/albumin nanoparticles to improve bioavailability and tumor targeting of atovaquone, enhancing the efficacy of anti-PD-1 therapy by normalizing tumor hypoxia.
[Journal of Nanobiotechnology]
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The Fellowship of Regulatory and Tissue-Resident Memory Cells

T cells located in non-lymphoid tissues have come to prominence in recent years. CD8+ tissue-resident memory cells are important for tissue immune surveillance, provide an important line of defence against invading pathogens and show promise in cancer therapies.
[Mucosal Immunology]
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PI3Kγδ Inhibitor plus Radiation Enhances the Antitumor Immune Effect of PD-1 Blockade in Syngenic Murine Breast Cancer and Humanized Patient-Derived Xenograft Model

Murine breast cancer cells were grown in both immune-competent and -deficient BALB/c mice, and tumors were irradiated by three fractions of 24 Gy. A PD-1 blockade and a phosphoinositide 3-kinase (PI3K)γδ inhibitor were then administered every other day for two weeks.
[European Journal of Cancer]
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Environmental Eustress Modulates β-ARs/CCL2 Axis to Induce Anti-tumor Immunity and Sensitize Immunotherapy against Liver Cancer in Mice

The authors demonstrated that mice living in an enriched environment were protected from carcinogen-induced liver neoplasia and transplantable syngeneic liver tumors, owning to a CD8+ T cell-dependent tumor control.
[Nature Communications]
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SEC61G Overexpression and DNA Amplification Correlates with Prognosis and Immune Cell Infiltration in Head and Neck Squamous Cell Carcinoma

SEC61G expression was analyzed using publicly available datasets. The association between SEC61G and disease prognosis was evaluated.
[Cancer Medicine]
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Dynamics of TCR Repertoire and T Cell Function in COVID-19 Convalescent Individuals

The authors presented both single-cell TCR-seq and RNA-seq to analyze the dynamics of TCR repertoire and immune metabolic functions of blood T cells collected from recently discharged COVID-19 patients.
[Cell Discovery]
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Lycopus lucidus Turcz Ameliorates DNCB-Induced Atopic Dermatitis in BALB/C Mice

The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.
[Molecular Medicine Reports]
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Regulation of the Immune Tolerance System Determines the Susceptibility to HLA-Mediated Abacavir-Induced Skin Toxicity

The authors showed the importance of immune tolerance for idiosyncratic drug toxicity (IDT) onset and determine whether it was susceptible to a common IDT, HLA-B*57:01-mediated abacavir-induced hypersensitivity, using CD4+ T cell-depleted programmed death-1 receptor-deficient HLA-B*57:01 transgenic mice
[Communications Biology]
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KIR3DS1 Directs NK Cell-Mediated Protection against Human Adenovirus Infections

To decipher immune recognition of human adenoviruse (HAdV) infection and determine new targets for immune-mediated control, researchers used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells.
[Science Immunology]
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Single-Cell Profiling Defines the Prognostic Benefit of CD39high Tissue Resident Memory CD8+ T Cells in Luminal-Like Breast Cancer

By using high-dimensional single-cell technologies, scientists identified heterogeneous behavior within the tissue-resident memory CD8+ T cells infiltrating luminal-like tumors.
[Communications Biology]
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CD8+ T Effector and Immune Checkpoint Signatures Predict Prognosis and Responsiveness to Immunotherapy in Bladder Cancer

348 pretreated metastatic urothelial cancer samples from the IMvigor210 cohort were used to identify important genes significantly associated with CD8+ T effector and immune checkpoint signatures.
[Oncogene]
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