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CD8

HCV Infection Alters Salivary Gland Histology and Saliva Composition

[Journal of Dental Research] Researchers investigated if xerostomia associated with salivary gland (SG) and hepatitis C virus (HCV) infection and characterized the structural changes in SG and saliva composition.

Interleukin-37 Promotes Colitis-Associated Carcinogenesis via SIGIRR-Mediated Cytotoxic T Cells Dysfunction

[Signal Transduction and Targeted Therapy] Researchers found that IL-37 transgenic mice were highly susceptible to colitis-associated colorectal cancer and suffered from dramatically increased tumor burdens in colon.

Proximity of Immune and Tumor Cells Underlies Response to BRAF/MEK-Targeted Therapies in Metastatic Melanoma Patients

[npj Precision Oncology] In a TCGA-melanoma dataset, tumor cellularity exhibited additive prognostic value in the immune score signature to predict overall survival in patients with early-stage melanoma.

Single‐Cell Immune Mapping of Melanoma Sentinel Lymph Nodes Reveals an Actionable Immunotolerant Microenvironment

[Clinical Cancer Research] Researchers used mass cytometry by time-of-flight, flow cytometry, and T cell receptor immunosequencing to conduct simultaneous single-cell analyses of immune cells in the sentinel lymph nodes of melanoma patients.

Interleukin-37 Promotes Colitis-Associated Carcinogenesis via SIGIRR-Mediated Cytotoxic T Cells Dysfunction

[Signal Transduction and Targeted Therapy] Scientists found that IL-37 transgenic mice were highly susceptible to colitis-associated colorectal cancer and suffered from dramatically increased tumor burdens in colon.

DJ-1 Depletion Prevents Immunoaging in T Cell Compartments

[EMBO Reports] Investigators showed that loss of DJ-1 encoded by PARK7/DJ-1, causing early-onset familial Parkinson’s disease, unexpectedly diminished signs of immunoaging in T cell compartments of both human and mice.

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