Tag results:
CD8
Immunology of Infectious Disease News
MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8+ T Cell Responses
[Journal of Immunology] Using miRNA microarray profiling, investigators characterized the expression profile of naive and in vivo generated murine effector antiviral CD8+ T cells.
Immune Regulation News
Control of Tumors by Antigen-Specific CD8+ T Cells through PDL1-Targeted Delivery of Antigenic Peptide
[Journal of Immunology Research] Scientists generated a therapeutic chimeric protein containing the PD-L1 single-chain variable fragment linked to a cleavable model cytotoxic T lymphocyte epitope: E7 CTL peptide.
Immune Regulation News
Loss of CMTM6 Promotes DNA Damage-Induced Cellular Senescence and Antitumor Immunity
[Oncoimmunology] Investigators showed that chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) was upregulated in clear cell renal cell carcinoma tissues and was strongly associated with advanced tumor grades, early metastases, and a worse prognosis.
Human Immunology News
Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes
[Journal of Immunology] The authors observed significantly fewer LAG-3+ CD4 and CD8 T cells from subjects with relapsing-remitting multiple sclerosis and type 1 diabetes.
Mammary Cell News
KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGF-β Activity
[Molecular Cancer Research] Using MCF10A as a model of non-tumorigenic epithelial breast cells, scientists found that silencing KDM6A promoted cell migration and transformation demonstrated by the formation of tumor-like acini in three-dimensional culture.
Cell Therapy News
B Cells Imprint Adoptively Transferred CD8+ T Cells with Enhanced Tumor Immunity
[Journal For Immunotherapy of Cancer] Researchers investigated how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes were impacted when expanded ex vivo with the TLR9 agonist CpG.