Investigators evaluated the role of mouse double minute 2 homolog (MDM2) in T-cell-mediated immune resistance. Ovarian clear cell carcinoma cell lines carrying wild-type p53 with low/high MDM2 expression were investigated in a T-cell co-culture system evaluating T-cell-mediated tumor killing.
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Rath, J. A., Bajwa, G., Carreres, B., Hoyer, E., Gruber, I., Martínez-Paniagua, M. A., … Arber, C. (2020). Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4+ T cells. Science Advances, 6(27), eaaz7809. https://doi.org/10.1126/sciadv.aaz7809 Cite
Researchers identified circulating CD88−CD1c+CD163+ denritic cells (DCs) as immediate precursors of inflammatory CD88−CD14+CD1c+CD163+FcεRI+ DCs.
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Bourdely, P., Anselmi, G., Vaivode, K., Ramos, R. N., Missolo-Koussou, Y., Hidalgo, S., … Guermonprez, P. (2020). Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.06.002 Cite
Scientists developed a novel CD8+ CAR T-cell product, Descartes-08, with predictable pharmacokinetics for treatment of multiple myeloma. Descartes-08 was engineered by mRNA transfection to express anti-BCMA CAR for a defined length of time.
Researchers suggested a previously unidentified method for xenogenizing tumors by using fusogenic exosomes to introduce fusogenic viral antigens onto the tumor cell surface.
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The authors revealed a TGFβ–SKI–Smad4 pathway that critically and specifically directed resident CD103+CD8+ T cell generation for protective immunity against primary and secondary viral infection.
[Cellular & Molecular Immunology]
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In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a peptide and takes it to the cell surface for surveillance by lymphocytes.
[Annual Review of Biochemistry]
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Djaoud, Z., & Parham, P. (2020). HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity. Annual Review of Biochemistry, 89(1), 717–739. https://doi.org/10.1146/annurev-biochem-011520-102754 Cite
Researchers showed that IL-18BP, a high-affinity IL-18 decoy receptor, was frequently upregulated in diverse human and mouse tumors and limited the anti-tumor activity of IL-18 in mice.
Investigators discuss how the role of NK cells evolves with tumor progression, presenting new opportunities to target NK cell function to enhance cancer immunotherapy response rates across a more diverse range of cancers.
[Nature Reviews Cancer]
Scientists describe the thymic development of NK T cells, mucosal-associated invariant T (MAIT) cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.
[Nature Reviews Immunology]
Investigators evaluated the CD4+ and CD8+ responses to influenza A and B infection in a cohort of solid organ transplant patients.
Researchers showed that peripheral infections generated antigen-specific CD8+ memory T cells in the brain that adopted a unique tissue resident memory signature.