CD8

[Science Advances] Using an immune “hot” mouse ovarian cancer model, scientists found that cancer-associated-MSCs drove CD8+ T cell tumor immune exclusion and reduced response to anti–PD-L1 immune checkpoint inhibitor via secretion of numerous chemokines.

[British Journal of Cancer] Scientists examined the relationship between the tumor microenvironment and the clinical efficacy of neoadjuvant chemotherapy in patients with cT2-4aN0M0 bladder cancer using multiplex fluorescence immunohistochemistry.

[Cell Reports] Scientists examined the role of miR-29 in neonatal and adult CD8+ T cells, which expressed different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge.

[Science Immunology] Scientists showed that activation of the WNT/β-catenin signaling pathway contributed to the development of a noninflamed tumor microenvironment in tumors with high tumor mutation burden.

[Molecular Therapy-Oncolytics] Scientists found that oncolytic adenovirus conferred an effective ability to reduce ascites development and prolong overall survival.

[Cell Reports] Investigators showed that autotaxin (ATC) secreted by melanoma cells was chemorepulsive for tumor-infiltrating lymphocytes and circulating CD8+ T cells ex vivo, with autotaxin functioning as an LPA-producing chaperone.