CD8

[PLoS Pathogens] The authors investigated the impact of monocytes, NK cells, and CD8+ T cells in primary HTLV-1 infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type or to the HTLV-1p12KO mutant.

[Nature Biotechnology] By testing immunogenicity with autologous blood lymphocytes from patients with cancer, scientists detected pre-established CD4+ and CD8+ T cell responses for 10 of 21 and for 1 of 30 previously identified gene fusions, respectively.

[eLife] The authors demonstrated that homology cluster analysis of T cell receptor (TCR) repertoires efficiently identified tumor-reactive TCRs.

[Immunity] Scientists identified transcriptionally distinct exhausted T cell subpopulations, mapped their differentiation trajectories via transitory cellular states toward exhausted CD8+ T cells, and localized these cell states to specific splenic niches.

[Journal of Controlled Release] Scientists developed an in situ sustained-release hydrogel delivery system for combined chemo-immunotherapy of glioma by combined chemotherapy drug and immunoadjuvant through the resection cavity local delivery.

[Stem Cell Reports] Scientists report successful targeting of the CCR5 locus in iPSCs generated from T cells or fibroblasts from Mauritian cynomolgus macaques, using CRISPR-Cas9 technology.