CD8

[Nature Communications] Investigators systematically dissected pancreatic ductal adenocarcinoma intrinsic mechanisms of immune evasion by in vitro and in vivo CRISPR screening, and identified Vps4b and Rnf31 as essential factors required for escaping CD8+ T cell killing.

[Scientific Reports] Investigators characterized the distribution of tumor infiltrating lymphocytes (TILs) and TLSs using CD3, CD4, CD8, CD20 immunohistochemistry in a cohort of 10 eccrine porocarcinoma (EPCs) and 49 EPs.

[Journal of Experimental Medicine] Scientists demonstrated that cutaneous vaccinia virus infection by scarification activates dermal lymphatic capillary junction tightening and lymph node lymphangiogenesis, which were associated with reduced fluid transport and cutaneous viral sequestration.

[Scientific Reports] The authors investigated the features of CCR8+ Tregs in lung cancer patients. CCR8+ Tregs were highly activated and infiltration of CCR8+ Tregs in tumors was associated with poor prognosis in lung cancer patients.

[Nature Communications] The authors hypothesized that TGF-β receptor inhibition may alter pancreatic ductal adenocarcinoma progression and antitumor immunity in the tumor microenvironment.

[Biomarker Research] Inactivation of BCL11B were performed by CRISPR/Cas9 in human T cells. Immunophenotypic and transcriptional profiles of sgBCL11B T cells were characterized by cytometer and transcriptomics, respectively.