CD8

[Nature] Researchers studied CD8 T cells in patients with human papillomavirus (HPV)-positive head and neck cancer and identified several epitopes derived from HPV E2, E5 and E6 proteins that allowed us to analyse virus-specific CD8 T cells using major histocompatibility complex class I tetramers.

[Nature Communications] Using multiplex immunofluorescence staining in cohorts of anti-PD-1 and anti-PD-L1-treated lung cancer patients, scientists showed that decreased expression of cancer cell αV was associated with improved immunotherapy-related, progression-free survival.

[Aging-Us] Researchers established in vitro cultured mixed-natural killer cells (NKM) to achieve immune normalization. The in vitro cytotoxicity of NKM cells was tenfold higher than that of peripheral blood mononuclear cells

[Immunity] By sensing IL-2 and cross-presenting hepatocellular antigens, a subset of kupffer cells overcame the tolerogenic potential of the hepatic microenvironment, suggesting new strategies for boosting hepatic T cell immunity.

[Immunity] Researchers used a mouse model of hepatitis B virus (HBV) infection, in which HBV-specific naive CD8+ T cells recognizing hepatocellular antigens were driven into a state of immune dysfunction, to identify a subset of Kupffer cells that cross-presents hepatocellular antigens upon interleukin-2 administration.

[EMBO Molecular Medicine] The authors employed gene transfer into hematopoietic stem and progenitor cells to selectively express anti-tumoral cytokines in tumor-infiltrating monocytes/macrophages.