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CD8

Recovery from Acute SARS-CoV-2 Infection and Development of Anamnestic Immune Responses in T Cell-Depleted Rhesus Macaques

[mBio] To investigate the specific role of T cells in recovery from SARS-CoV-2 infections, researchers studied rhesus macaques that were depleted of either CD4+, CD8+, or both T cell subsets prior to infection.

miR-526b-3p Inhibits Lung Cancer Cisplatin-Resistance and Metastasis by Inhibiting STAT3-Promoted PD-L1

[Cell Death & Disease] Researchers found that miR-526b-3p expression declined while programmed cell death protein ligand 1 (PD-L1) was elevated in cisplatin-resistant lung cancer compared to that in cisplatin-sensitive lung cancer by analyzing clinical samples.

Differentiation of Exhausted CD8+ T Cells after Termination of Chronic Antigen Stimulation Stops Short of Achieving Functional T Cell Memory

[Nature Immunology] The authors confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus infection before and after treatment.

Synthetic Multiepitope Neoantigen DNA Vaccine for Personalized Cancer Immunotherapy

[Nanomedicine-Nanotechnology Biology and Medicine] A DNA vaccine was efficiently uptaken by dendritic cells and induced effective immune response against mouse melanoma cells, leading to significant inhibition of melanoma tumor growth and reduction of lung metastasis in a mouse model.

Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells

[Cancer Research] To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunological manipulation with non-invasive, longitudinal imaging, the authors generated a penetrant double oncogene-driven autochthonous model of neuroblastoma.

Anti-Tumor Immunity in Mismatch Repair-Deficient Colorectal Cancers Requires Type I IFN–Driven CCL5 and CXCL10

[Journal of Experimental Medicine] The authors discovered that selective recruitment and activation of systemic CD8+ T cells into DNA mismatch repair colorectal cancers strictly depend on overexpression of CCL5 and CXCL10 due to endogenous activation of cGAS/STING and type I IFN signaling by damaged DNA.

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