Single-Cell Transcriptomics Identifies Multiple Pathways Underlying Antitumor Function of TCR and CD8αβ-Engineered Human CD4+ T Cells

Investigators evaluated the role of mouse double minute 2 homolog (MDM2) in T-cell-mediated immune resistance. Ovarian clear cell carcinoma cell lines carrying wild-type p53 with low/high MDM2 expression were investigated in a T-cell co-culture system evaluating T-cell-mediated tumor killing.
[Science Advances]
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Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Researchers identified circulating CD88CD1c+CD163+ denritic cells (DCs) as immediate precursors of inflammatory CD88CD14+CD1c+CD163+FcεRI+ DCs.
[Immunity]
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Preclinical Evaluation of CD8+ Anti-BCMA mRNA CAR T Cells for Treatment of Multiple Myeloma

Scientists developed a novel CD8+ CAR T-cell product, Descartes-08, with predictable pharmacokinetics for treatment of multiple myeloma. Descartes-08 was engineered by mRNA transfection to express anti-BCMA CAR for a defined length of time.
[Leukemia]
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Xenogenization of Tumor Cells by Fusogenic Exosomes in Tumor Microenvironment Ignites and Propagates Antitumor Immunity

Researchers suggested a previously unidentified method for xenogenizing tumors by using fusogenic exosomes to introduce fusogenic viral antigens onto the tumor cell surface.
[Science Advances]
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The SKI Proto-Oncogene Restrains the Resident CD103+CD8+ T Cell Response in Viral Clearance

The authors revealed a TGFβ–SKI–Smad4 pathway that critically and specifically directed resident CD103+CD8+ T cell generation for protective immunity against primary and secondary viral infection.
[Cellular & Molecular Immunology]
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HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity

In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a peptide and takes it to the cell surface for surveillance by lymphocytes.
[Annual Review of Biochemistry]
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IL-18BP Is a Secreted Immune Checkpoint and Barrier to IL-18 Immunotherapy

Researchers showed that IL-18BP, a high-affinity IL-18 decoy receptor, was frequently upregulated in diverse human and mouse tumors and limited the anti-tumor activity of IL-18 in mice.
[Nature]
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The Cancer–Natural Killer Cell Immunity Cycle

Investigators discuss how the role of NK cells evolves with tumor progression, presenting new opportunities to target NK cell function to enhance cancer immunotherapy response rates across a more diverse range of cancers.
[Nature Reviews Cancer]
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Thymic Development of Unconventional T Cells: How NKT Cells, MAIT Cells and γδ T Cells Emerge

Scientists describe the thymic development of NK T cells, mucosal-associated invariant T (MAIT) cells and γδ T cells and highlight some of the key differences between conventional and unconventional T cell development.
[Nature Reviews Immunology]
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T-Cell Responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients

Investigators evaluated the CD4+ and CD8+ responses to influenza A and B infection in a cohort of solid organ transplant patients.
[Scientific Reports]
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Peripherally Induced Brain Tissue–Resident Memory CD8+ T Cells Mediate Protection against CNS Infection

Researchers showed that peripheral infections generated antigen-specific CD8+ memory T cells in the brain that adopted a unique tissue resident memory signature.
[Nature Immunology]
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