CD8

[Nature Cancer] Scientists established a novel mechanism by which castration mediated IL-8 secretion and subsequent polymorphonuclear myeloid-derived suppressor cells infiltration.

[Stem Cell Research & Therapy] Scientists assessed the safety and efficacy of injecting intravenous Wharton’s jelly-derived MSCs in patients with COVID-19 as a treatment. Five patients with severe COVID-19 were treated with Wharton’s jelly-derived mesenchymal stem cells.

[Cancer Research] Investigators showed that inhibition of the hyperactive mevalonate (MVA) metabolic pathway in tumor cells elicited type 1 classical dendritic cells-mediated tumor recognition and antigen cross-presentation for antitumor immunity.

[Nature Medicine] Researchers used Hannover Medical School’s COVID-19 Contact Study cohort of healthcare professionals to monitor ChAdOx1-nCov-19 (ChAd)-primed immune responses before and three weeks after booster with ChAd or BioNTech/Pfizer’s BNT162b2.

[Journal of Pathology] The authors characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in the prostate tumor microenvironment.

[Scientific Reports] Scientists identified cellular subpopulations of epithelial cancer cells and their microenvironment and validated their results by multiplex immunofluorescence applied to a tissue microarray of long and short-predicted survival lung adenocarcinoma.