CD8

[Nature Reviews Immunology] The authors review CD8+ T cell differentiation to dysfunctional states during tumorigenesis.

[Genes & Diseases] With a predicted peptide library from SARS-CoV-2 S and N proteins, restricted to three of the most prominent HLA-A alleles in the Asian population, investigators found that specific CD8+ T cell responses were identified in over 75% of COVID-19 convalescent patients

[Reproductive Sciences] Using a tube formation assay between HTR8/SVneo cells and human umbilical vein endothelial cells, scientists found that Tim-3 pathway blockade inhibits tube formation and reversed by addition of recombinant IL-4 and/or IL-10.

[Science Translational Medicine] Researchers observed that tumor cell intrinsic loss of A20 markedly enhanced lung tumorigenesis and was associated with reduced CD8+ T cell–mediated immune surveillance in patients with lung cancer and in mouse models.

[Science Translational Medicine] To specifically trigger sufficient antitumor reactivity without notable adverse effects, scientists developed an antigen and adjuvant codelivery nanoparticle vaccine based on Escherichia coli cytoplasmic membranes (EMs) and tumor cell membranes (TMs) from resected autologous tumor tissue.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers reported that ventrolateral medulla (VLM) catecholaminergic neurons in the mouse brain were activated in tumor-bearing mice and the activity of these neurons significantly altered tumor growth in multiple syngeneic and spontaneous mouse tumor models.