Sequential Immunization Induces Strong and Broad Immunity against All Four Dengue Virus Serotypes

Scientists tested whether sequential immunization induces stronger and broader immunity against four dengue virus serotypes than tetravalent-formulated immunization.
[NPJ Vaccines]
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Specific Targeting of IL-1β Activity to CD8+ T Cells Allows for Safe Use as a Vaccine Adjuvant

Researchers present a bypass around these toxicities by targeting the activity of IL-1β to CD8+ T cells. Using this approach, they demonstrated safe inclusion of IL-1β as an adjuvant in vaccination strategies, leading to full protection of mice against a high influenza virus challenge dose by raising potent T cell responses.
[NPJ Vaccines]
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CD8+ Tumor-Infiltrating Lymphocytes within the Primary Tumor of Patients with Synchronous De Novo Metastatic Colorectal Carcinoma Do Not Track with Survival

Treatment‐naïve patients with metastatic colorectal cancer were assessed for CD8+ tumor-infiltrating lymphocutes and PD‐L1 expression. Microsatellite instability was evaluated by IHC for PMS2 and MSH6 proteins and/or by PCR using the Bethesda panel.
[Clinical & Translational Immunology]
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Drug Target Validation in Primary Human Natural Killer Cells Using CRISPR RNP

An efficient approach was described to genetically edit human NK cells by electroporation and CRISPR‐Cas9 ribonucleoprotein complexes.
[Journal of Leukocyte Biology]
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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

Scientists showed that the combination treatment of anti-PD1 and cisplatin enriched BMI1+ CSCs in head and neck squamous cell carcinoma (HNSCC) while inhibiting HNSCC growth.
[Cell Stem Cell]
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Intra-Articular Xenogeneic Mesenchymal Stem Cell-Based Therapy Increases CD4+CD25+ Cells in Synovial Fluid

The authors aimed to identify the lymphocytic response to a xenogeneic human umbilical cord-derived mesenchymal stem cell-based cell therapy.
[Veterinary Immunology and Immunopathology]
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Xenogeneic Mesenchymal Stem Cell Transplantation for Mandibular Defect Regeneration

To examine donor cell survival and host immune reaction, pig bone marrow‐derived mesenchymal stem cells were labeled with CM‐DiI, loaded onto gelatin sponge, and transplanted into 5‐mm mandibular defects of immunocompetent and T cell‐deficient athymic rats.
[Xenotransplantation]
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Immune Status Is Prognostic for Poor Survival in Colorectal Cancer Patients and Is Associated with Tumor Hypoxia

Overall survival by immune and immune-checkpoint biomarkers in independent colorectal cancer cohorts was evaluated. Matched mutational and transcriptomic data were interrogated to identify associated biology.
[British Journal of Cancer]
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Bacterial Immunotherapy for Cancer Induces CD4-Dependent Tumor-Specific Immunity through Tumor-Intrinsic Interferon-γ Signaling

Investigators showed that Bacillus Calmette–Guérin (GCG)-induced bladder tumor elimination required CD4 and CD8 T cells, although augmentation or inhibition of bacterial antigen-specific T cell responses did not alter the efficacy of BCG-induced tumor elimination.
[Proceedings of the National Academy of Sciences of the United States of America]
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Immunostimulatory and Anti-Tumor Metronomic Cyclophosphamide Regimens Assessed in Primary Orthotopic and Metastatic Murine Breast Cancer

Cyclophosphamide (CTX) increased expression of tumor cell PD-L1; however, when combined with concomitant PD-L1 antibody therapy none of the CTX regimens showed increased benefit.
[NPJ Breast Cancer]
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Therapeutic Vaccine-Mediated Gag-Specific CD8+ T-Cell Induction under Anti-Retroviral Therapy Augments Anti-Virus Efficacy of CD8+ Cells in Simian Immunodeficiency Virus-Infected Macaques

Researchers investigated the impact of therapeutic vaccination inducing virus-specific CD8+ T-cell responses under anti-retroviral therapy on viral control in a macaque AIDS model.
[Scientific Reports]
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