CD8

[Cancer Immunology, Immunotherapy] To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.

[Scientific Reports] In MC38 tumors, only endothelial cells (ECs) strongly express APJ, a cognate receptor for Apelin, indicating that EC-derived Apelin might regulate tumor formation in an autocrine manner.

[Cell Reports] The authors demonstrated the applicability of high-content imaging to human T and natural killer cells and develop a pipeline for unbiased analysis of high-definition morphological profiles.

[Leukemia] Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the angioimmunoblastic T-cell lymphoma tumor microenvironment.

[Immunity] Scientists demonstrated that precursors of exhausted T cells sustained mitochondrial fitness, including high spare respiratory capacity, while exhausted effector T cells deteriorated metabolically over time.

[Cell Death & Differentiation] When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring acute respiratory SARS-CoV-2 in 1063 patients, researchers found that malignant disease favored the magnitude and duration of viral RNA shedding concomitant with prolonged serum elevations of type 1 IFN that anticorrelated with anti-RBD IgG antibodies.