CD8

[Cell Reports] Mass spectrometry analysis on the supernatant of human melanoma cells revealed 12 peptides capable of priming healthy-donor CD8+ T cells that recognized and killed human melanoma cells in vitro and when xenotransplanted in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers suggested that missense p53 mutations may have contributed to worse PDAC prognosis by promoting a more vigorous fibrotic tumor microenvironment and impeded the ability of the immune system to eliminate the cancer cells.

[Abcuro, Inc.] Abcuro, Inc. and ImaginAb shared initial results of a study demonstrating the use of ImmunoPET technology to image T cell infiltration of skeletal muscle in patients with inclusion body myositis, an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability.

[Advanced Healthcare Materials] The construction of a 1,3-propanesultone-grafted zwitterionic dendrimer-entrapped gold nanoparticle platform chelated with Gd(III) for immune checkpoint modulation is reported.

[Cell] Investigators applied structure-based network analysis and assessments of HLA class I-peptide stability to define mutationally constrained CD8+ T cell epitopes across the SARS-CoV-2 proteome.

[Nature Communications] To elucidate the immunopathology underlying COVID-19 severity, researchers perform cytokine and multiplex immune profiling in COVID-19 patients.