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CD86

Therapeutic IGF-I Receptor Inhibition Alters Fibrocyte Immune Phenotype in Thyroid-Associated Ophthalmopathy

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that teprotumumab, an anti-insulin-like growth factor I receptor inhibitor, attenuated constitutive expression and induction by the thyroid-stimulating hormone of MHC II and these B7 members in CD34+ fibrocytes.

Distribution and Maturation State of Peripheral Blood Dendritic Cells in Children with Primary Hypertension

[Hypertension Research] Using multicolor flow cytometry, expression of maturation markers in total dendritic cells (DCs), myeloid DCs, and plasmacytoid DCs and the distribution of peripheral Th17-bearing and T-reg cells were defined.

Asxl1loss Cooperates with Oncogenic Nras in Mice to Reprogram Immune Microenvironment and Drive Leukemic Transformation

[Blood] Investigators showed that concurrent ASXL1 and NRAS mutations defined a population of chronic myelomonocytic leukemia patients with shorter leukemia-free survival than those with ASXL1 mutation only.

Treg-Expressed CTLA-4 Depletes CD80/CD86 by Trogocytosis, Releasing Free PD-L1 on Antigen-Presenting Cells

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that Treg-expressed CTLA-4 facilitated Treg-antigen-presenting cells conjugation and immune synapse formation.

Dendritic Cell Deficiencies Persist Seven Months after SARS-CoV-2 Infection

[Cellular & Molecular Immunology] Researchers described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers.

CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-Cell Responses

[Cancer Immunology Research] Researchers used multicolor flow cytometry and immunohistochemistry to elucidate abundance and spatial distribution of these antigen-presenting B cells in blood and tumor samples of 238 cancer patients.

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