Inhibition of Retinoic Acid Receptor α Phosphorylation Represses the Progression of Triple-Negative Breast Cancer via Transactivating miR-3074-5p to Target DHRS3

The anti-tumor activity of hypo-phosphorylated retinoic acid receptor α was investigated in TNBC cell models and a xenograft mouse model.
[Journal of Experimental & Clinical Cancer Research]
Lou, S., Gao, H., Hong, H., Zhu, Z., & Zhao, H. (2021). Inhibition of retinoic acid receptor α phosphorylation represses the progression of triple-negative breast cancer via transactivating miR-3074-5p to target DHRS3. Journal of Experimental & Clinical Cancer Research, 40(1), 141. https://doi.org/10.1186/s13046-021-01941-7 Cite
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Transcriptional Control of DNA Repair Networks by CDK7 Regulates Sensitivity to Radiation in MYC-Driven Medulloblastoma

To identify therapeutic targets in MYC-amplified medulloblastoma, investigators employed a CRISPR-Cas9 essentiality screen targeting 1,140 genes. They identified CDK7 as a mediator of medulloblastoma tumorigenesis.
[Cell Reports]
Veo, B., Danis, E., Pierce, A., Wang, D., Fosmire, S., Sullivan, K. D., Joshi, M., Khanal, S., Dahl, N., Karam, S., Serkova, N., Venkataraman, S., & Vibhakar, R. (2021). Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma. Cell Reports, 35(4). https://doi.org/10.1016/j.celrep.2021.109013 Cite
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