Alteration of Immunophenotype of Human Macrophages and Monocytes after Exposure to Cigarette Smoke

Using human monocyte-derived macrophages (MDMs) from healthy donors, researchers found that cigarette smoke exposure was not associated with significant changes in the production of pro inflammatory cytokines by MDMs.
[Scientific Reports]
da Silva, C. O., Gicquel, T., Daniel, Y., Bártholo, T., Vène, E., Loyer, P., Pôrto, L. C., Lagente, V., & Victoni, T. (2020). Alteration of immunophenotype of human macrophages and monocytes after exposure to cigarette smoke. Scientific Reports, 10(1), 12796. https://doi.org/10.1038/s41598-020-68753-1 Cite
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Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Researchers investigated whether the pharmacological sirtuin 1 activator SRT2104 protects against Type II alveolar epithelial cell senescence in rats with emphysema.
[COPD-Journal of Chronic Obstructive Pulmonary Disease]
Gu, C., Zhang, Q., Ni, D., Xiao, Q.-F., Cao, L.-F., Fei, C.-Y., Ying, Y., Li, N., & Tao, F. (2020). Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. COPD: Journal of Chronic Obstructive Pulmonary Disease, 0(0), 1–8. https://doi.org/10.1080/15412555.2020.1797657 Cite
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Breztri Aerosphere Approved in the US for the Maintenance Treatment of COPD

AstraZeneca’s Breztri Aerosphere has been approved in the US for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD).
[AstraZeneca]
Press Release

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