Hedgehog Interacting Protein (HHIP) Represses Airway Remodeling and Metabolic Reprogramming in COPD-Derived Airway Smooth Muscle Cells

Researchers suggest that HHIP repressed aerobic glycolysis and airway smooth muscle cells hyperplasia, which might contribute to the increased airway remodeling in Hhip+/- mice.
[Scientific Reports]
Li, Y., Zhang, L., Polverino, F., Guo, F., Hao, Y., Lao, T., Xu, S., Li, L., Pham, B., Owen, C. A., & Zhou, X. (2021). Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells. Scientific Reports, 11(1), 9074. https://doi.org/10.1038/s41598-021-88434-x Cite
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Small Airway Determinants of Airflow Limitation in Chronic Obstructive Pulmonary Disease

Small airways from patients with COPD showed thickening of epithelial and subepithelial tissue, mucus plugging and reduced collagen density in the airway wall in severe COPD.
[Thorax]
Polosukhin, V. V., Gutor, S. S., Du, R.-H., Richmond, B. W., Massion, P. P., Wu, P., Cates, J. M., Sandler, K. L., Rennard, S. I., & Blackwell, T. S. (2021). Small airway determinants of airflow limitation in chronic obstructive pulmonary disease. Thorax. https://doi.org/10.1136/thoraxjnl-2020-216037 Cite
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The Effects of the miR-21/SMAD7/TGF-β Pathway on Th17 Cell Differentiation in COPD

Scientists investigated the modulation of T-helper 17 cell differentiation by the miR-21/Smad7/TGF-β pathway, and their roles in chronic obstructive pulmonary disease (COPD).
[Scientific Reports]
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Role of Extracellular Vesicles in Chronic Lung Disease

The authors provide a broad overview of the roles of extracellular vesicles (EV) in chronic respiratory disease. Recent advances in profiling EVs have shown their potential as biomarker candidates. Further studies have provided insight into their disease pathology, particularly in inflammatory processes across a spectrum of lung diseases.
[Thorax]
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RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of COPD

The effect of cigarette smoke extract on RANKL/RANK expression and that of exogenous RANKL on ubiquitin-proteasome pathway in C2C12 myotubes were investigated in vitro.
[American Journal of Respiratory Cell and Molecular Biology]
Xiong, J., Le, Y., Rao, Y., Zhou, L., Hu, Y., Guo, S., & Sun, Y. (2021). RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of COPD. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2020-0449OC Cite
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Olodaterol Exerts Anti-inflammatory Effects on COPD Airway Epithelial Cells

Human bronchial epithelial brushing from patients with and without COPD were cultured into air–liquid interface cultures and treated with or without olodaterol and respiratory syncytial virus infection to examine the effect on markers of inflammation including interleukin-8 and mucus secretion.
[Respiratory Research]
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Resident Interstitial Lung Fibroblasts and Their Role in Alveolar Stem Cell Niche Development, Homeostasis, Injury, and Regeneration

The authors summarize the role of alveolar fibroblasts and their activation stage in alveolar septation and regeneration and incorporate them into the context of human lung disease, discussing fibroblast activation stages and how they contribute to bronchopulmonary dysplasia, idiopathic pulmonary fibrosis, and COPD.
[Stem Cells Translational Medicine]
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Epithelial Cells and Inflammation in Pulmonary Wound Repair

The authors examine the pivotal role of pulmonary airway epithelial cells in initiating and moderating tissue repair and restitution.
[Cells]
Croasdell Lucchini, A., Gachanja, N. N., Rossi, A. G., Dorward, D. A., & Lucas, C. D. (2021). Epithelial Cells and Inflammation in Pulmonary Wound Repair. Cells, 10(2), 339. https://doi.org/10.3390/cells10020339 Cite
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HIV Induces Airway Basal Progenitor Cells to Adopt an Inflammatory Phenotype

Researchers hypothesized that HIV induced the basal stem/progenitor cells to express inflammatory mediators that contributed to the pathogenesis of emphysema.
[Scientific Reports]
Chung, N. P. Y., Khan, K. M. F., Kaner, R. J., O’Beirne, S. L., & Crystal, R. G. (2021). HIV induces airway basal progenitor cells to adopt an inflammatory phenotype. Scientific Reports, 11(1), 3988. https://doi.org/10.1038/s41598-021-82143-1 Cite
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BET Proteins Are Associated with the Induction of Small Airway Fibrosis in COPD

Primary human airway smooth muscle cells from COPD and non-COPD smoking patients were stimulated with TGF-β1. Gene array analysis performed to identify differences in ECM expression.
[Thorax]

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Organicell Announces FDA Approval of IND Application for the Use of Zofin™ in the Treatment of Chronic Obstructive Pulmonary Disease (COPD)

Organicell Regenerative Medicine, Inc. announced that the FDA has approved the Investigational New Drug application for its lead product, Zofin™, in the treatment of patients diagnosed with chronic obstructive pulmonary disease.
[Organicell Regenerative Medicine, Inc.]
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