Air Pollution-Regulated E-Cadherin Mediates Contact Inhibition of Proliferation via the Hippo Signaling Pathways in Emphysema

Researchers investigated the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure.
[Chemico-Biological interactions]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Persistent Pulmonary Pathology after COVID-19 Is Associated with High Viral Load, Weak Antibody Response, and High Levels of Matrix Metalloproteinase-9

The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19.
[Scientific Reports]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Vitamin E Relieves Chronic Obstructive Pulmonary Disease by Inhibiting COX2-Mediated P-STAT3 Nuclear Translocation through the EGFR/MAPK Signaling Pathway

Scientists explored the protective effect of vitamin E on chronic obstructive pulmonary disease and the underlying mechanisms.
[Laboratory Investigation]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Home Dust Allergen Exposure is Associated with Outcomes Among Sensitized Individuals with COPD

Allergen sensitization to five common indoor allergens was assessed in former smokers with COPD. Home settled dust was assessed for presence of corresponding allergens.
[American Journal of Respiratory and Critical Care Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Role of Lysocardiolipin Acyltransferase in Cigarette Smoke-Induced Lung Epithelial Cell Mitochondrial ROS, Mitochondrial Dynamics, and Apoptosis

Researchers investigated the role of lysocardiolipin acyltransferase expression and activity in mitochondrial oxidative stress, mitochondrial dynamics, and lung epithelial cell apoptosis.
[Cell Biochemistry and Biophysics]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

PRMT7 Targets of Foxm1 Controls Alveolar Myofibroblast Proliferation and Differentiation during Alveologenesis

Scientists provide evidence for PRMT7’s function in regulating alveolar myofibroblasts proliferation and differentiation during lung alveologenesis.
[Cell Death & Disease]
[zotpress userid=” items=’VQJDFZUA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

p300/Sp1-Mediated High Expression of p16 Promotes Endothelial Progenitor Cell Senescence Leading to the Occurrence of Chronic Obstructive Pulmonary Disease

Peripheral blood endothelial progenitor cells were isolated from nonsmoking non-chronic obstructive pulmonary disease (COPD), smoking non-COPD, and smoking COPD patients. The expressions of p16, p300, and senescence-related genes were detected by RT-PCR and Western Blot.
[Mediators of Inflammation]
[zotpress userid=” items=’XUST55PE’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

EPAS1 (Endothelial PAS Domain Protein 1) Orchestrates Transactivation of Endothelial ICAM1 (Intercellular Adhesion Molecule 1) by Small Nucleolar RNA Host Gene 5 (SNHG5 ) to Promote Hypoxic Pulmonary Hypertension

Scientists confirmed that EPAS1-specific inhibitor PT2385 ameliorated HPH features, as demonstrated by right ventricle hypertrophy, right ventricular systolic pressure, and pulmonary vascular remodeling.
[Hypertension]
[zotpress userid=” items=’R253FIPH’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Transcriptional Profiling of Circulating Mononuclear Cells from Patients with Chronic Obstructive Pulmonary Disease Receiving Mesenchymal Stromal Cell Infusions

Allogeneic, bone marrow-derived MSCs were systemically administered into patients with stable chronic obstructive pulmonary disease. Gene expression profiles from peripheral blood mononuclear cells were analyzed across the first week after infusion.
[Stem Cells Translational Medicine]
[zotpress userid=” items=’EFV462L9′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

LL-37 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE

The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
[zotpress userid=” items=’N9D8UDGJ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

EpiEndo Pharmaceuticals Secures EUR 20 Million Series a Funding to Advance Clinical Development of Its Non-antibiotic Macrolide for the Treatment of COPD

EpiEndo Pharmaceuticals, Inc. announced the closing of a €20m Series A financing round led by Flerie Invest and Iðunn Venture Fund, with existing investors ABC Ventures participating, along with the European Innovation Council (EIC) Fund joining the round. The financing secures funds to advance clinical development of EpiEndo’s lead compound EP395, which entered phase I clinical trials in April, through Phase IIa, targeting COPD as a primary indication.
[EpiEndo Pharmaceuticals, Inc.]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share
Share