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COPD

The Arginine Methyltransferase PRMT7 Promotes Extravasation of Monocytes Resulting in Tissue Injury in COPD

[Nature Communications] Scientists showed that in COPD patients, protein arginine methyltransferase 7 (PRMT7) expression was elevated in the lung tissue and localized to the macrophages.

Mesenchymal Stem Cell-Based Treatments for COVID-19: Status and Future Perspectives for Clinical Applications

[Cellular and Molecular Life Sciences] Investigators describe the origins, pathogenesis, and clinical features of COVID-19 and the potential uses of MSCs in therapeutic treatments for severe acute respiratory syndrome coronavirus 2-infected patients.

Epithelial Plasticity in COPD Results in Cellular Unjamming Due to an Increase in Polymerized Actin

[Journal of Cell Science] Both cigarette smoke-exposed and COPD-patient derived epithelia displayed quantitative evidence of cellular plasticity, with loss of specialized apical features and a transcriptional profile suggestive of partial epithelial to mesenchymal transition, albeit with distinct cell motion indicative of cellular unjamming.

Nuclear Factor-Kappa B (NF-κB) Inhibition as a Therapeutic Target for Plant Nutraceuticals in Mitigating Inflammatory Lung Diseases

[Chemico-Biological interactions] Scientists discuss the medical value of nutraceuticals briefly and their ability to mitigate various inflammatory lung diseases through targeting inhibition of NF-κB.

Characterization of the COPD Alveolar Niche Using Single-Cell RNA Sequencing

[Nature Communications] The authors analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.

Hypoxia Increases the Potential for Neutrophil-Mediated Endothelial Damage in COPD

[American Journal of Respiratory and Critical Care Medicine] The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterized by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed.

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