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COPD

EpiEndo Pharmaceuticals Secures EUR 20 Million Series a Funding to Advance Clinical Development of Its Non-antibiotic Macrolide for the Treatment of COPD

[EpiEndo Pharmaceuticals, Inc.] EpiEndo Pharmaceuticals, Inc. announced the closing of a €20m Series A financing round led by Flerie Invest and Iðunn Venture Fund, with existing investors ABC Ventures participating, along with the European Innovation Council (EIC) Fund joining the round. The financing secures funds to advance clinical development of EpiEndo’s lead compound EP395, which entered phase I clinical trials in April, through Phase IIa, targeting COPD as a primary indication.

LL-37 and HMGB1 Induce Alveolar Damage and Reduce Lung Tissue Regeneration via RAGE

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The effects of the receptor for advanced glycation end-products (RAGE) ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE deficient mice and on lung damage and repair responses using murine precision cut lung slices and organoids.

Signaling Pathway Perturbation Analysis for Assessment of Biological Impact of Cigarette Smoke on Lung Cells

[Scientific Reports] Investigators reported the development of an algorithm based on quantitative assessment of transcriptomic profiles and signaling pathway perturbation analysis of human bronchial epithelial cells exposed to the toxic components present in cigarette smoke.

Tempo-Spatial Regulation of the Wnt Pathway by FAM13A Modulates the Stemness of Alveolar Epithelial Progenitors

[Ebiomedicine] Florescence-activated flow cytometry analysis, immunofluorescence and organoid culture system were performed to identify the β-catenin/Wnt-activated cells in Fam13a+/+ or Fam13a−/− mice exposed to CS.

Loss of FCHSD1 Leads to Amelioration of Chronic Obstructive Pulmonary Disease

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that the expression level of FCH and double SH3 domains 1 (FCHSD1) was drastically increased in mice in response to elastase instillation, an experimental model of chronic obstructive pulmonary disease. FCHSD1 is a member of the F-BAR family with two SH3 domains.

Autophagy of Mucin Granules Contributes to Resolution of Airway Mucous Metaplasia

[Scientific Reports] Researchers hypothesized that the autophagy pathway was required for resolution of mucous metaplasia by eliminating excess non-secreted intracellular mucin granules.

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