CTLA4-chimeric antigen receptor T cells were found to accumulate in tumors and are toxic to myeloid-derived suppressor cells without signs of severe GVHD and CRS in preclinical models.
[Frontiers in Immunology]
Lin, S., Cheng, L., Ye, W., Li, S., Zheng, D., Qin, L., Wu, Q., Long, Y., Lin, S., Wang, S., Huang, G., Li, P., Yao, Y., & Sun, X. (2021). Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86–Positive B Cell Malignancies. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.642528 Cite
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